DICP OpenIR
Subject Area物理化学
Protein-imprinted materials: rational design, application and challenges
Yang, Kaiguang; Zhang, Lihua; Liang, Zhen; Zhang, Yukui; Zhang LH(张丽华)
KeywordMolecular Imprinting Protein Antibody Recognition Sites
Source PublicationANALYTICAL AND BIOANALYTICAL CHEMISTRY
2012-06-01
DOI10.1007/s00216-012-5840-y
Volume403Issue:8Pages:2173-2183
Indexed BySCI
SubtypeReview
Department18
Funding Project1810
Contribution Rank1,1
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectBiochemical Research Methods ; Chemistry, Analytical
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS KeywordUNIQUE ELECTROPHORESIS TECHNIQUE ; MINUTE STRUCTURAL DIFFERENCES ; ARTIFICIAL GEL ANTIBODIES ; CAPILLARY-ELECTROPHORESIS ; EPITOPE APPROACH ; LIQUID-CHROMATOGRAPHY ; UNIVERSAL METHOD ; AQUEOUS-MEDIA ; RECOGNITION ; POLYMERS
AbstractProtein imprinting is a promising tool for generating artificial biomimetic receptors with antibody-like specific recognition sites. Recently, protein-imprinted materials, as potential antibody substitutes, have attracted much attention in many fields, for example chemical sensors, chromatographic stationary phases, and artificial enzymes, owing to their long-term storage stability, potential re-usability, resistance to harsh environment, and low cost. In this critical review, we focus our discussion on the rational preparation of protein-imprinted materials in terms of choice of template, functional monomer, crosslinker, and polymerization format. In addition, several highlighted applications of protein-imprinted materials are emphasized, not only in well-known fields but also in some unique fields, for example proteomics and tissue engineering. Finally, we propose challenges arising from the intrinsic properties of protein imprinting, for example obtaining the template, heterogeneous binding, and extrinsic competition, for example immobilized aptamers.
Language英语
WOS IDWOS:000305127200010
Citation statistics
Cited Times:69[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/118174
Collection中国科学院大连化学物理研究所
Corresponding AuthorZhang LH(张丽华)
AffiliationChinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Yang, Kaiguang,Zhang, Lihua,Liang, Zhen,et al. Protein-imprinted materials: rational design, application and challenges[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2012,403(8):2173-2183.
APA Yang, Kaiguang,Zhang, Lihua,Liang, Zhen,Zhang, Yukui,&张丽华.(2012).Protein-imprinted materials: rational design, application and challenges.ANALYTICAL AND BIOANALYTICAL CHEMISTRY,403(8),2173-2183.
MLA Yang, Kaiguang,et al."Protein-imprinted materials: rational design, application and challenges".ANALYTICAL AND BIOANALYTICAL CHEMISTRY 403.8(2012):2173-2183.
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