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学科主题: 物理化学
题名: Protein-imprinted materials: rational design, application and challenges
作者: Yang, Kaiguang1;  Zhang, Lihua1;  Liang, Zhen1;  Zhang, Yukui1
通讯作者: 张丽华
关键词: Molecular imprinting ;  Protein ;  Antibody ;  Recognition sites
刊名: ANALYTICAL AND BIOANALYTICAL CHEMISTRY
发表日期: 2012-06-01
DOI: 10.1007/s00216-012-5840-y
卷: 403, 期:8, 页:2173-2183
收录类别: SCI
文章类型: Review
部门归属: 18
项目归属: 1810
产权排名: 1,1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: Protein imprinting is a promising tool for generating artificial biomimetic receptors with antibody-like specific recognition sites. Recently, protein-imprinted materials, as potential antibody substitutes, have attracted much attention in many fields, for example chemical sensors, chromatographic stationary phases, and artificial enzymes, owing to their long-term storage stability, potential re-usability, resistance to harsh environment, and low cost. In this critical review, we focus our discussion on the rational preparation of protein-imprinted materials in terms of choice of template, functional monomer, crosslinker, and polymerization format. In addition, several highlighted applications of protein-imprinted materials are emphasized, not only in well-known fields but also in some unique fields, for example proteomics and tissue engineering. Finally, we propose challenges arising from the intrinsic properties of protein imprinting, for example obtaining the template, heterogeneous binding, and extrinsic competition, for example immobilized aptamers.
关键词[WOS]: UNIQUE ELECTROPHORESIS TECHNIQUE ;  MINUTE STRUCTURAL DIFFERENCES ;  ARTIFICIAL GEL ANTIBODIES ;  CAPILLARY-ELECTROPHORESIS ;  EPITOPE APPROACH ;  LIQUID-CHROMATOGRAPHY ;  UNIVERSAL METHOD ;  AQUEOUS-MEDIA ;  RECOGNITION ;  POLYMERS
语种: 英语
WOS记录号: WOS:000305127200010
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/118174
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China

Recommended Citation:
Yang, Kaiguang,Zhang, Lihua,Liang, Zhen,et al. Protein-imprinted materials: rational design, application and challenges[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2012,403(8):2173-2183.
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