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学科主题物理化学
Protein-imprinted materials: rational design, application and challenges
Yang, Kaiguang; Zhang, Lihua; Liang, Zhen; Zhang, Yukui; Zhang LH(张丽华)
关键词Molecular Imprinting Protein Antibody Recognition Sites
刊名ANALYTICAL AND BIOANALYTICAL CHEMISTRY
2012-06-01
DOI10.1007/s00216-012-5840-y
403期:8页:2173-2183
收录类别SCI
文章类型Review
部门归属18
项目归属1810
产权排名1,1
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]UNIQUE ELECTROPHORESIS TECHNIQUE ; MINUTE STRUCTURAL DIFFERENCES ; ARTIFICIAL GEL ANTIBODIES ; CAPILLARY-ELECTROPHORESIS ; EPITOPE APPROACH ; LIQUID-CHROMATOGRAPHY ; UNIVERSAL METHOD ; AQUEOUS-MEDIA ; RECOGNITION ; POLYMERS
英文摘要Protein imprinting is a promising tool for generating artificial biomimetic receptors with antibody-like specific recognition sites. Recently, protein-imprinted materials, as potential antibody substitutes, have attracted much attention in many fields, for example chemical sensors, chromatographic stationary phases, and artificial enzymes, owing to their long-term storage stability, potential re-usability, resistance to harsh environment, and low cost. In this critical review, we focus our discussion on the rational preparation of protein-imprinted materials in terms of choice of template, functional monomer, crosslinker, and polymerization format. In addition, several highlighted applications of protein-imprinted materials are emphasized, not only in well-known fields but also in some unique fields, for example proteomics and tissue engineering. Finally, we propose challenges arising from the intrinsic properties of protein imprinting, for example obtaining the template, heterogeneous binding, and extrinsic competition, for example immobilized aptamers.
语种英语
WOS记录号WOS:000305127200010
引用统计
被引频次:65[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/118174
专题中国科学院大连化学物理研究所
通讯作者Zhang LH(张丽华)
作者单位Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China
推荐引用方式
GB/T 7714
Yang, Kaiguang,Zhang, Lihua,Liang, Zhen,et al. Protein-imprinted materials: rational design, application and challenges[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2012,403(8):2173-2183.
APA Yang, Kaiguang,Zhang, Lihua,Liang, Zhen,Zhang, Yukui,&张丽华.(2012).Protein-imprinted materials: rational design, application and challenges.ANALYTICAL AND BIOANALYTICAL CHEMISTRY,403(8),2173-2183.
MLA Yang, Kaiguang,et al."Protein-imprinted materials: rational design, application and challenges".ANALYTICAL AND BIOANALYTICAL CHEMISTRY 403.8(2012):2173-2183.
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