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学科主题: 物理化学
题名: Improvement of peptoid chiral stationary phases by modifying the terminal group of selector
作者: Wu, Haibo1;  Su, Xiaobing1;  Li, Kuiyong1;  Yu, Hui1;  Ke, Yanxiong1;  Liang, Xinmiao1, 2
通讯作者: 梁鑫淼 ;  柯燕雄
关键词: Peptoid ;  Oligopeptoid ;  Chiral stationary phase ;  Chiral separation
刊名: JOURNAL OF CHROMATOGRAPHY A
发表日期: 2012-11-23
DOI: 10.1016/j.chroma.2012.09.081
卷: 1265, 页:181-185
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1803
产权排名: 2,6
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: The role of a terminal group of a peptoid selector in a chiral separation was investigated. Six chiral stationary phases (CSPs) with the terminal groups replaced by achiral alkyl groups (n-butyl, t-butyl and diisopropyl) and chiral groups ((1R, 2R)-2-aminocyclohexyl phenylcarbamate, N'-phenyl-L-proline amide and N'-phenyl-L-leucine amide) were synthesized. Achiral terminal groups with different steric hindrances did not broaden the enantioselectivity, but improved the separation factors for some analytes, probably due to the improvement of interactions between the analytes and peptoid chain. Introducing new chiral terminal groups proved an effective way to broaden the applicable spectrum of peptoid CSPs. (C) 2012 Elsevier B.V. All rights reserved.
关键词[WOS]: ENANTIOMERIC SEPARATIONS ;  LIQUID-CHROMATOGRAPHY ;  PERFORMANCE ;  COLUMNS ;  HPLC
语种: 英语
WOS记录号: WOS:000311011000022
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/118177
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.E China Univ Sci & Technol, Sch Pharm, Minist Educ, Engn Res Ctr Pharmaceut Proc Chem, Shanghai 200237, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

Recommended Citation:
Wu, Haibo,Su, Xiaobing,Li, Kuiyong,et al. Improvement of peptoid chiral stationary phases by modifying the terminal group of selector[J]. JOURNAL OF CHROMATOGRAPHY A,2012,1265:181-185.
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