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学科主题: 物理化学
题名: Potent and selective inhibition of magnolol on catalytic activities of UGT1A7 and 1A9
作者: Zhu, Liangliang1, 2;  Ge, Guangbo1;  Liu, Yong1;  He, Guiyuan1, 2;  Liang, Sicheng1;  Fang, Zhongze1, 2;  Dong, Peipei3;  Cao, Yunfeng1;  Yang, Ling1
通讯作者: 杨凌
关键词: Magnolol ;  UDP-glucuronosyltransferases ;  glucuronidation ;  UGT inhibitor
刊名: XENOBIOTICA
发表日期: 2012-10-01
DOI: 10.3109/00498254.2012.681814
卷: 42, 期:10, 页:1001-1008
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1806
产权排名: 1,1
类目[WOS]: Pharmacology & Pharmacy ;  Toxicology
研究领域[WOS]: Pharmacology & Pharmacy ;  Toxicology
英文摘要: 1. Human exposure to magnolol can reach a high dose in daily life. Our previous studies indicated that magnolol showed high affinities to several UDP-glucuronosyltransferases (UGTs) This study was designed to examine the in vitro inhibitory effects of magnolol on UGTs, and further to evaluate the possibility of the in vivo inhibition that might happen.
关键词[WOS]: HUMAN UDP-GLUCURONOSYLTRANSFERASES ;  HUMAN LIVER-MICROSOMES ;  IN-VITRO ;  GLUCURONIDATION ;  KINETICS ;  ANDROSTERONE ;  SPECIFICITY ;  ENZYMES ;  SINGLE ;  UGT2B7
语种: 英语
WOS记录号: WOS:000308411600006
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/118185
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China
3.Dalian Med Univ, Res Inst Integrated Tradit & Western Med, Dalian, Peoples R China

Recommended Citation:
Zhu, Liangliang,Ge, Guangbo,Liu, Yong,et al. Potent and selective inhibition of magnolol on catalytic activities of UGT1A7 and 1A9[J]. XENOBIOTICA,2012,42(10):1001-1008.
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