DICP OpenIR
Subject Area物理化学
Potent and selective inhibition of magnolol on catalytic activities of UGT1A7 and 1A9
Zhu, Liangliang1,2; Ge, Guangbo1; Liu, Yong1; He, Guiyuan1,2; Liang, Sicheng1; Fang, Zhongze1,2; Dong, Peipei3; Cao, Yunfeng1; Yang, Ling1; Yang L(杨凌)
KeywordMagnolol Udp-glucuronosyltransferases Glucuronidation Ugt Inhibitor
Source PublicationXENOBIOTICA
2012-10-01
DOI10.3109/00498254.2012.681814
Volume42Issue:10Pages:1001-1008
Indexed BySCI
SubtypeArticle
Department18
Funding Project1806
Contribution Rank1,1
WOS SubjectPharmacology & Pharmacy ; Toxicology
WOS Research AreaPharmacology & Pharmacy ; Toxicology
WOS KeywordHUMAN UDP-GLUCURONOSYLTRANSFERASES ; HUMAN LIVER-MICROSOMES ; IN-VITRO ; GLUCURONIDATION ; KINETICS ; ANDROSTERONE ; SPECIFICITY ; ENZYMES ; SINGLE ; UGT2B7
Abstract1. Human exposure to magnolol can reach a high dose in daily life. Our previous studies indicated that magnolol showed high affinities to several UDP-glucuronosyltransferases (UGTs) This study was designed to examine the in vitro inhibitory effects of magnolol on UGTs, and further to evaluate the possibility of the in vivo inhibition that might happen.
Language英语
WOS IDWOS:000308411600006
Citation statistics
Cited Times:34[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/118185
Collection中国科学院大连化学物理研究所
Corresponding AuthorYang L(杨凌)
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China
3.Dalian Med Univ, Res Inst Integrated Tradit & Western Med, Dalian, Peoples R China
Recommended Citation
GB/T 7714
Zhu, Liangliang,Ge, Guangbo,Liu, Yong,et al. Potent and selective inhibition of magnolol on catalytic activities of UGT1A7 and 1A9[J]. XENOBIOTICA,2012,42(10):1001-1008.
APA Zhu, Liangliang.,Ge, Guangbo.,Liu, Yong.,He, Guiyuan.,Liang, Sicheng.,...&杨凌.(2012).Potent and selective inhibition of magnolol on catalytic activities of UGT1A7 and 1A9.XENOBIOTICA,42(10),1001-1008.
MLA Zhu, Liangliang,et al."Potent and selective inhibition of magnolol on catalytic activities of UGT1A7 and 1A9".XENOBIOTICA 42.10(2012):1001-1008.
Files in This Item:
File Name/Size DocType Version Access License
2012GqdvXpPjmy.PDF(943KB) 开放获取--Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhu, Liangliang]'s Articles
[Ge, Guangbo]'s Articles
[Liu, Yong]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhu, Liangliang]'s Articles
[Ge, Guangbo]'s Articles
[Liu, Yong]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhu, Liangliang]'s Articles
[Ge, Guangbo]'s Articles
[Liu, Yong]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.