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学科主题物理化学
Potent and selective inhibition of magnolol on catalytic activities of UGT1A7 and 1A9
Zhu, Liangliang1,2; Ge, Guangbo1; Liu, Yong1; He, Guiyuan1,2; Liang, Sicheng1; Fang, Zhongze1,2; Dong, Peipei3; Cao, Yunfeng1; Yang, Ling1; Yang L(杨凌)
关键词Magnolol Udp-glucuronosyltransferases Glucuronidation Ugt Inhibitor
刊名XENOBIOTICA
2012-10-01
DOI10.3109/00498254.2012.681814
42期:10页:1001-1008
收录类别SCI
文章类型Article
部门归属18
项目归属1806
产权排名1,1
类目[WOS]Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]Pharmacology & Pharmacy ; Toxicology
关键词[WOS]HUMAN UDP-GLUCURONOSYLTRANSFERASES ; HUMAN LIVER-MICROSOMES ; IN-VITRO ; GLUCURONIDATION ; KINETICS ; ANDROSTERONE ; SPECIFICITY ; ENZYMES ; SINGLE ; UGT2B7
英文摘要1. Human exposure to magnolol can reach a high dose in daily life. Our previous studies indicated that magnolol showed high affinities to several UDP-glucuronosyltransferases (UGTs) This study was designed to examine the in vitro inhibitory effects of magnolol on UGTs, and further to evaluate the possibility of the in vivo inhibition that might happen.
语种英语
WOS记录号WOS:000308411600006
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/118185
专题中国科学院大连化学物理研究所
通讯作者Yang L(杨凌)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China
3.Dalian Med Univ, Res Inst Integrated Tradit & Western Med, Dalian, Peoples R China
推荐引用方式
GB/T 7714
Zhu, Liangliang,Ge, Guangbo,Liu, Yong,et al. Potent and selective inhibition of magnolol on catalytic activities of UGT1A7 and 1A9[J]. XENOBIOTICA,2012,42(10):1001-1008.
APA Zhu, Liangliang.,Ge, Guangbo.,Liu, Yong.,He, Guiyuan.,Liang, Sicheng.,...&杨凌.(2012).Potent and selective inhibition of magnolol on catalytic activities of UGT1A7 and 1A9.XENOBIOTICA,42(10),1001-1008.
MLA Zhu, Liangliang,et al."Potent and selective inhibition of magnolol on catalytic activities of UGT1A7 and 1A9".XENOBIOTICA 42.10(2012):1001-1008.
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