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学科主题: 物理化学
题名: Taxol-induced alteration of intracellular amino-acid profile related to human cervical carcinoma HeLa cell death
作者: Han, Xiao-Fei1;  Liu, Yan-Qiu1;  Wang, Long-Xing1;  Yang, Qian-Xu1;  Xiao, Hong-Bin1
通讯作者: 肖红斌
关键词: L-Alanine ;  Intracellular amino-acid profile ;  Human cervical carcinoma HeLa cell ;  Taxol
刊名: BIOTECHNOLOGY LETTERS
发表日期: 2012
DOI: 10.1007/s10529-011-0730-5
卷: 34, 期:1, 页:1-7
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1804
产权排名: 1,1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biotechnology & Applied Microbiology
研究领域[WOS]: Biotechnology & Applied Microbiology
英文摘要: The anti-tumor action of Taxol was investigated in the changes of amino-acids involved in tumor cell survival. By tracing the intracellular amino-acid profiles of HeLa cells treated with non-conditioned and three conditioned media (Taxol, l-alanine, and Taxol + l-alanine), it was observed that an alteration of amino-acid metabolism participates in Taxol-induced death of HeLa cells. The contents of 18 out of 21 detected amino-acids are 5-95% and the ones of lysine and methionine are 158 and 117% of the corresponding contents in the control after treatment with Taxol for 24 h, respectively. Addition of l-alanine inhibited cell apoptosis upon Taxol treatment by partially blocking the increase of lysine and methionine and reversing decrease trend of alanine, glycine, and glutamic acid. These results suggest that interference of amino-acid metabolism might be an important mechanism of Taxol cytotoxicity.
关键词[WOS]: INDUCED APOPTOSIS ;  CANCER CELLS ;  GROWTH ;  LYSINE ;  DEPRIVATION ;  IMBALANCE
语种: 英语
WOS记录号: WOS:000297862100001
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/118191
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China

Recommended Citation:
Han, Xiao-Fei,Liu, Yan-Qiu,Wang, Long-Xing,et al. Taxol-induced alteration of intracellular amino-acid profile related to human cervical carcinoma HeLa cell death[J]. BIOTECHNOLOGY LETTERS,2012,34(1):1-7.
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