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学科主题物理化学
Taxol-induced alteration of intracellular amino-acid profile related to human cervical carcinoma HeLa cell death
Han, Xiao-Fei; Liu, Yan-Qiu; Wang, Long-Xing; Yang, Qian-Xu; Xiao, Hong-Bin; Xiao HB(肖红斌)
关键词L-alanine Intracellular Amino-acid Profile Human Cervical Carcinoma Hela Cell Taxol
刊名BIOTECHNOLOGY LETTERS
2012
DOI10.1007/s10529-011-0730-5
34期:1页:1-7
收录类别SCI
文章类型Article
部门归属18
项目归属1804
产权排名1,1
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Biotechnology & Applied Microbiology
研究领域[WOS]Biotechnology & Applied Microbiology
关键词[WOS]INDUCED APOPTOSIS ; CANCER CELLS ; GROWTH ; LYSINE ; DEPRIVATION ; IMBALANCE
英文摘要The anti-tumor action of Taxol was investigated in the changes of amino-acids involved in tumor cell survival. By tracing the intracellular amino-acid profiles of HeLa cells treated with non-conditioned and three conditioned media (Taxol, l-alanine, and Taxol + l-alanine), it was observed that an alteration of amino-acid metabolism participates in Taxol-induced death of HeLa cells. The contents of 18 out of 21 detected amino-acids are 5-95% and the ones of lysine and methionine are 158 and 117% of the corresponding contents in the control after treatment with Taxol for 24 h, respectively. Addition of l-alanine inhibited cell apoptosis upon Taxol treatment by partially blocking the increase of lysine and methionine and reversing decrease trend of alanine, glycine, and glutamic acid. These results suggest that interference of amino-acid metabolism might be an important mechanism of Taxol cytotoxicity.
语种英语
WOS记录号WOS:000297862100001
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/118191
专题中国科学院大连化学物理研究所
通讯作者Xiao HB(肖红斌)
作者单位Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
推荐引用方式
GB/T 7714
Han, Xiao-Fei,Liu, Yan-Qiu,Wang, Long-Xing,et al. Taxol-induced alteration of intracellular amino-acid profile related to human cervical carcinoma HeLa cell death[J]. BIOTECHNOLOGY LETTERS,2012,34(1):1-7.
APA Han, Xiao-Fei,Liu, Yan-Qiu,Wang, Long-Xing,Yang, Qian-Xu,Xiao, Hong-Bin,&肖红斌.(2012).Taxol-induced alteration of intracellular amino-acid profile related to human cervical carcinoma HeLa cell death.BIOTECHNOLOGY LETTERS,34(1),1-7.
MLA Han, Xiao-Fei,et al."Taxol-induced alteration of intracellular amino-acid profile related to human cervical carcinoma HeLa cell death".BIOTECHNOLOGY LETTERS 34.1(2012):1-7.
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