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学科主题: 物理化学
题名: BmK-YA, an Enkephalin-Like Peptide in Scorpion Venom
作者: Zhang, Yan1;  Xu, Junyan2;  Wang, Zhiwei1;  Zhang, Xiuli2;  Liang, Xinmiao2;  Civelli, Olivier1, 3, 4
通讯作者: 梁鑫淼 ;  CivelliOlivier
刊名: PLOS ONE
发表日期: 2012-07-09
DOI: 10.1371/journal.pone.0040417
卷: 7, 期:7, 页:404171
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1803
产权排名: 2,2
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
英文摘要: By screening extracts of venom from the Asian scorpion Buthus martensii Karsch (BmK) for their abilities to activate opioid receptors, we have identified BmK-YA, an amidated peptide containing an enkephalin-like sequence. BmK-YA is encoded by a precursor that displays a signal sequence and contains four copies of BmK-YA sequences and four of His(4)-BmK-YA, all flanked by single amino acid residues. BmK-YA and His(4)-BmK-YA are amidated and thus fulfill the characteristics expected of bioactive peptides. BmK-YA can activate mammalian opioid receptors with selectivity for the delta subtype while His(4)-BmK-YA is inactive at opioid receptors. The discovery of BmK-YA suggests that scorpion venom may represent a novel source of bioactive molecules targeting G protein-coupled receptors (GPCRs) and reveal additional insights on the evolution of the opioid precursors.
关键词[WOS]: BUTHUS-MARTENSII KARSCH ;  MOLECULAR CHARACTERIZATION ;  OPIOID RECEPTOR ;  3-FINGER TOXIN ;  IDENTIFICATION ;  NEUROTOXINS ;  PROENKEPHALIN ;  ANTAGONIST ;  EXENDIN-4 ;  CHANNELS
语种: 英语
WOS记录号: WOS:000306354700045
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/118208
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Univ Calif Irvine, Dept Pharmacol, Irvine, CA 92717 USA
2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
3.Univ Calif Irvine, Dept Dev & Cell Biol, Irvine, CA 92717 USA
4.Univ Calif Irvine, Dept Pharmaceut Sci, Irvine, CA USA

Recommended Citation:
Zhang, Yan,Xu, Junyan,Wang, Zhiwei,et al. BmK-YA, an Enkephalin-Like Peptide in Scorpion Venom[J]. PLOS ONE,2012,7(7):404171.
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