DICP OpenIR
Subject Area物理化学
BmK-YA, an Enkephalin-Like Peptide in Scorpion Venom
Zhang, Yan1; Xu, Junyan2; Wang, Zhiwei1; Zhang, Xiuli2; Liang, Xinmiao2; Civelli, Olivier1,3,4; Liang XM(梁鑫淼); CivelliOlivier
Source PublicationPLOS ONE
2012-07-09
ISSN1932-6203
DOI10.1371/journal.pone.0040417
Volume7Issue:7Pages:404171
Indexed BySCI
SubtypeArticle
Department18
Funding Project1803
Contribution Rank2,2
WOS SubjectMultidisciplinary Sciences
WOS Research AreaScience & Technology - Other Topics
WOS KeywordBUTHUS-MARTENSII KARSCH ; MOLECULAR CHARACTERIZATION ; OPIOID RECEPTOR ; 3-FINGER TOXIN ; IDENTIFICATION ; NEUROTOXINS ; PROENKEPHALIN ; ANTAGONIST ; EXENDIN-4 ; CHANNELS
AbstractBy screening extracts of venom from the Asian scorpion Buthus martensii Karsch (BmK) for their abilities to activate opioid receptors, we have identified BmK-YA, an amidated peptide containing an enkephalin-like sequence. BmK-YA is encoded by a precursor that displays a signal sequence and contains four copies of BmK-YA sequences and four of His(4)-BmK-YA, all flanked by single amino acid residues. BmK-YA and His(4)-BmK-YA are amidated and thus fulfill the characteristics expected of bioactive peptides. BmK-YA can activate mammalian opioid receptors with selectivity for the delta subtype while His(4)-BmK-YA is inactive at opioid receptors. The discovery of BmK-YA suggests that scorpion venom may represent a novel source of bioactive molecules targeting G protein-coupled receptors (GPCRs) and reveal additional insights on the evolution of the opioid precursors.
Language英语
WOS IDWOS:000306354700045
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/118208
Collection中国科学院大连化学物理研究所
Corresponding AuthorLiang XM(梁鑫淼); CivelliOlivier
Affiliation1.Univ Calif Irvine, Dept Pharmacol, Irvine, CA 92717 USA
2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
3.Univ Calif Irvine, Dept Dev & Cell Biol, Irvine, CA 92717 USA
4.Univ Calif Irvine, Dept Pharmaceut Sci, Irvine, CA USA
Recommended Citation
GB/T 7714
Zhang, Yan,Xu, Junyan,Wang, Zhiwei,et al. BmK-YA, an Enkephalin-Like Peptide in Scorpion Venom[J]. PLOS ONE,2012,7(7):404171.
APA Zhang, Yan.,Xu, Junyan.,Wang, Zhiwei.,Zhang, Xiuli.,Liang, Xinmiao.,...&CivelliOlivier.(2012).BmK-YA, an Enkephalin-Like Peptide in Scorpion Venom.PLOS ONE,7(7),404171.
MLA Zhang, Yan,et al."BmK-YA, an Enkephalin-Like Peptide in Scorpion Venom".PLOS ONE 7.7(2012):404171.
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