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学科主题: 物理化学
题名: Breath Pentane as a Potential Biomarker for Survival in Hepatic Ischemia and Reperfusion Injury-A Pilot Study
作者: Wang, Changsong1;  Shi, Jinghui2;  Sun, Bo1;  Liu, Desheng1;  Li, Peng1;  Gong, Yulei1;  He, Ying1;  Liu, Shujuan1;  Xu, Guowang3;  Li, Jianyi4;  Luo, Ailin2;  Li, Enyou1
通讯作者: 许国旺
刊名: PLOS ONE
发表日期: 2012-09-11
DOI: 10.1371/journal.pone.0044940
卷: 7, 期:9, 页:449401
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1808
产权排名: 3, 9
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
英文摘要: Background: Exhaled pentane, which is produced as a consequence of reactive oxygen species-mediated lipid peroxidation, is a marker of oxidative stress. Propofol is widely used as a hypnotic agent in intensive care units and the operating room. Moreover, this agent has been reported to inhibit lipid peroxidation by directly scavenging reactive oxygen species. In this study, using a porcine liver ischemia-reperfusion injury model, we have evaluated the hypothesis that high concentrations of breath pentane are related to adverse outcome and that propofol could reduce breath pentane and improve liver injury and outcome in swine in this situation.
关键词[WOS]: CRITICALLY-ILL PATIENTS ;  MEDIATED LIPID-PEROXIDATION ;  OXIDATIVE STRESS ;  DIPHENYL DISELENIDE ;  HYDROGEN-PEROXIDE ;  PROPOFOL ;  LIVER ;  RAT ;  CELL ;  EXPRESSION
语种: 英语
WOS记录号: WOS:000308638700100
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/118210
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Harbin Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Harbin, Peoples R China
2.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Anesthesiol, Wuhan 430074, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
4.Third High Sch Harbin, Harbin, Peoples R China

Recommended Citation:
Wang, Changsong,Shi, Jinghui,Sun, Bo,et al. Breath Pentane as a Potential Biomarker for Survival in Hepatic Ischemia and Reperfusion Injury-A Pilot Study[J]. PLOS ONE,2012,7(9):449401.
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