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学科主题: 物理化学
题名: Analysis of Urinary Metabolic Signatures of Early Hepatocellular Carcinoma Recurrence after Surgical Removal Using Gas Chromatography-Mass Spectrometry
作者: Ye, Guozhu1;  Zhu, Bin2;  Yao, Zhenzhen3;  Yin, Peiyuan1;  Lu, Xin1;  Kong, Hongwei1;  Fan, Fei2;  Jiao, Binghua3;  Xu, Guowang1
通讯作者: BinghuaJiao ;  许国旺
关键词: urine ;  metabolomics ;  hepatocellular carcinoma ;  GC-MS ;  surgery ;  metabolic signature ;  recurrence
刊名: JOURNAL OF PROTEOME RESEARCH
发表日期: 2012-08-01
DOI: 10.1021/pr300502v
卷: 11, 期:8, 页:4361-4372
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1808
产权排名: 1, 1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemical Research Methods
研究领域[WOS]: Biochemistry & Molecular Biology
英文摘要: The objective of present study was to offer insights into the metabolic responses of hepatocellular carcinoma (HCC) to surgical resection and the metabolic signatures latent in early HCC recurrence (one year after operation). Urinary metabolic profiling employing gas chromatography time-of-flight mass spectrometry (GC-TOF MS) was utilized to investigate the complex physiopathologic regulations in HCC after operational intervention. It was revealed that an intricate series of metabolic regulations including energy metabolism, amino acid metabolism, nucleoside metabolism, tricarboxylic acid (TCA) cycle, gut floral metabolism, etc., principally leading to the direction of biomass synthesis, could be observed after tumor surgical removal. Moreover, metabolic differences between recurrent and nonrecurrent patients had emerged 7 days after initial operation. The metabolic signatures of HCC recurrence principally comprised notable up-regulations of lactate excretion, succinate production, purine and pyrimidine nucleosides turnover, glycine, serine and threonine metabolism, aromatic amino acid turnover, cysteine and methionine metabolism, and glyoxylate metabolism, similar to metabolic behaviors of HCC burden. Sixteen metabolites were found to be significantly increased in the recurrent patients compared with those in nonrecurrent patients and healthy controls. Five metabolites (ethanolamine, lactic acid, acotinic acid, phenylalanine and ribose) were further defined; they were favorable to the prediction of early recurrence.
关键词[WOS]: BREAST-CANCER ;  CELLS ;  METABOANALYST ;  METABONOMICS ;  ETHANOLAMINE ;  METASTASIS ;  PROFILES ;  PATHWAY ;  CHOLINE ;  RATS
语种: 英语
WOS记录号: WOS:000307037600040
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/118228
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Dept Biliary Surg 2, Shanghai 200438, Peoples R China
3.Second Mil Med Univ, Dept Biochem & Mol Biol, Shanghai 200433, Peoples R China

Recommended Citation:
Ye, Guozhu,Zhu, Bin,Yao, Zhenzhen,et al. Analysis of Urinary Metabolic Signatures of Early Hepatocellular Carcinoma Recurrence after Surgical Removal Using Gas Chromatography-Mass Spectrometry[J]. JOURNAL OF PROTEOME RESEARCH,2012,11(8):4361-4372.
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