DICP OpenIR
学科主题物理化学
Analysis of Urinary Metabolic Signatures of Early Hepatocellular Carcinoma Recurrence after Surgical Removal Using Gas Chromatography-Mass Spectrometry
Ye, Guozhu1; Zhu, Bin2; Yao, Zhenzhen3; Yin, Peiyuan1; Lu, Xin1; Kong, Hongwei1; Fan, Fei2; Jiao, Binghua3; Xu, Guowang1; BinghuaJiao; Xu GW(许国旺)
关键词Urine Metabolomics Hepatocellular Carcinoma Gc-ms Surgery Metabolic Signature Recurrence
刊名JOURNAL OF PROTEOME RESEARCH
2012-08-01
DOI10.1021/pr300502v
11期:8页:4361-4372
收录类别SCI
文章类型Article
部门归属18
项目归属1808
产权排名1, 1
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Biochemical Research Methods
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]BREAST-CANCER ; CELLS ; METABOANALYST ; METABONOMICS ; ETHANOLAMINE ; METASTASIS ; PROFILES ; PATHWAY ; CHOLINE ; RATS
英文摘要The objective of present study was to offer insights into the metabolic responses of hepatocellular carcinoma (HCC) to surgical resection and the metabolic signatures latent in early HCC recurrence (one year after operation). Urinary metabolic profiling employing gas chromatography time-of-flight mass spectrometry (GC-TOF MS) was utilized to investigate the complex physiopathologic regulations in HCC after operational intervention. It was revealed that an intricate series of metabolic regulations including energy metabolism, amino acid metabolism, nucleoside metabolism, tricarboxylic acid (TCA) cycle, gut floral metabolism, etc., principally leading to the direction of biomass synthesis, could be observed after tumor surgical removal. Moreover, metabolic differences between recurrent and nonrecurrent patients had emerged 7 days after initial operation. The metabolic signatures of HCC recurrence principally comprised notable up-regulations of lactate excretion, succinate production, purine and pyrimidine nucleosides turnover, glycine, serine and threonine metabolism, aromatic amino acid turnover, cysteine and methionine metabolism, and glyoxylate metabolism, similar to metabolic behaviors of HCC burden. Sixteen metabolites were found to be significantly increased in the recurrent patients compared with those in nonrecurrent patients and healthy controls. Five metabolites (ethanolamine, lactic acid, acotinic acid, phenylalanine and ribose) were further defined; they were favorable to the prediction of early recurrence.
语种英语
WOS记录号WOS:000307037600040
引用统计
被引频次:32[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/118228
专题中国科学院大连化学物理研究所
通讯作者BinghuaJiao; Xu GW(许国旺)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Second Mil Med Univ, Eastern Hepatobiliary Surg Hosp, Dept Biliary Surg 2, Shanghai 200438, Peoples R China
3.Second Mil Med Univ, Dept Biochem & Mol Biol, Shanghai 200433, Peoples R China
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Ye, Guozhu,Zhu, Bin,Yao, Zhenzhen,et al. Analysis of Urinary Metabolic Signatures of Early Hepatocellular Carcinoma Recurrence after Surgical Removal Using Gas Chromatography-Mass Spectrometry[J]. JOURNAL OF PROTEOME RESEARCH,2012,11(8):4361-4372.
APA Ye, Guozhu.,Zhu, Bin.,Yao, Zhenzhen.,Yin, Peiyuan.,Lu, Xin.,...&许国旺.(2012).Analysis of Urinary Metabolic Signatures of Early Hepatocellular Carcinoma Recurrence after Surgical Removal Using Gas Chromatography-Mass Spectrometry.JOURNAL OF PROTEOME RESEARCH,11(8),4361-4372.
MLA Ye, Guozhu,et al."Analysis of Urinary Metabolic Signatures of Early Hepatocellular Carcinoma Recurrence after Surgical Removal Using Gas Chromatography-Mass Spectrometry".JOURNAL OF PROTEOME RESEARCH 11.8(2012):4361-4372.
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