DICP OpenIR
Subject Area物理化学
Chiral Tridentate P,N,N Ligands for Highly Enantioselective Copper-Catalyzed Propargylic Amination with both Primary and Secondary Amines as Nucleophiles
Zhang, Cheng1,2; Wang, Ya-Hui1; Hu, Xin-Hu1; Zheng, Zhuo1; Xu, Jie1; Hu, Xiang-Ping1; Hu XP(胡向平)
KeywordAsymmetric Catalysis Copper Primary Amines Propargylic Amination Secondary Amines
Source PublicationADVANCED SYNTHESIS & CATALYSIS
2012-10-01
DOI10.1002/adsc.201200589
Volume354Issue:14-15Pages:2854-2858
Indexed BySCI ; IC ; CCR
SubtypeArticle
Department2;DNL06
Funding Project02T2;DNL0601
Contribution Rank1,1
WOS HeadingsScience & Technology ; Physical Sciences
WOS SubjectChemistry, Applied ; Chemistry, Organic
WOS Research AreaChemistry
WOS KeywordASYMMETRIC ALKYNYLATION ; SUBSTITUTION-REACTIONS ; CARBONYL GROUPS ; IMINES ; ALKYNES ; ESTERS ; ADDITIONS ; ACCESS
AbstractChiral tridentate P,N,N ligands have been demonstrated to be highly efficient for the copper-catalyzed enantioselective propargylic amination of propargylic acetates with both primary and secondary amines as nucleophiles, affording the corresponding propargylic amines in high yields and with excellent enantioselectivities (up to 97% ee for secondary amines, and up to 96% ee for primary amines). Furthermore, the present catalytic system was also effective for the more challenging aliphatic propargylic acetate substrates.
Language英语
WOS IDWOS:000309907300035
Citation statistics
Cited Times:44[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/118266
Collection中国科学院大连化学物理研究所
Corresponding AuthorHu XP(胡向平)
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Cheng,Wang, Ya-Hui,Hu, Xin-Hu,et al. Chiral Tridentate P,N,N Ligands for Highly Enantioselective Copper-Catalyzed Propargylic Amination with both Primary and Secondary Amines as Nucleophiles[J]. ADVANCED SYNTHESIS & CATALYSIS,2012,354(14-15):2854-2858.
APA Zhang, Cheng.,Wang, Ya-Hui.,Hu, Xin-Hu.,Zheng, Zhuo.,Xu, Jie.,...&胡向平.(2012).Chiral Tridentate P,N,N Ligands for Highly Enantioselective Copper-Catalyzed Propargylic Amination with both Primary and Secondary Amines as Nucleophiles.ADVANCED SYNTHESIS & CATALYSIS,354(14-15),2854-2858.
MLA Zhang, Cheng,et al."Chiral Tridentate P,N,N Ligands for Highly Enantioselective Copper-Catalyzed Propargylic Amination with both Primary and Secondary Amines as Nucleophiles".ADVANCED SYNTHESIS & CATALYSIS 354.14-15(2012):2854-2858.
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