DICP OpenIR
Subject Area物理化学
Lipidomics Reveals Multiple Pathway Effects of a Multi-Components Preparation on Lipid Biochemistry in ApoE*3Leiden.CETP Mice
Wei, Heng1,2; Hu, Chunxiu3,4; Wang, Mei2,5; van den Hoek, Anita M.; Reijmers, Theo H.3,7; Wopereis, Suzan1; Bouwman, Jildau1,7; Ramaker, Raymond1; Korthout, Henrie A. A. J.6; Vennik, Marco6; Hankemeier, Thomas3,7; Havekes, Louis M.8; Witkamp, Renger F.9; Verheij, Elwin R.1; Xu, Guowang2,4; van der Greef, Jan1,2,3,5; Xu GW(许国旺); JanvanderGreef
Source PublicationPLOS ONE
2012-01-23
DOI10.1371/journal.pone.0030332
Volume7Issue:1Pages:30332
Indexed BySCI
SubtypeArticle
Department18
Funding Project1808
Contribution Rank4,2
WOS SubjectMultidisciplinary Sciences
WOS Research AreaScience & Technology - Other Topics
WOS KeywordCHOLESTERYL ESTER TRANSFER ; SYSTEMS BIOLOGY ; APOE-ASTERISK-3-LEIDEN.CETP MICE ; AGGRAVATES ATHEROSCLEROSIS ; OVERWEIGHT PATIENTS ; CHINESE MEDICINE ; WEIGHT-REDUCTION ; TRANSFER PROTEIN ; HDL-CHOLESTEROL ; TRANSGENIC MICE
AbstractBackground: Causes and consequences of the complex changes in lipids occurring in the metabolic syndrome are only partly understood. Several interconnected processes are deteriorating, which implies that multi-target approaches might be more successful than strategies based on a limited number of surrogate markers. Preparations from Chinese Medicine (CM) systems have been handed down with documented clinical features similar as metabolic syndrome, which might help developing new intervention for metabolic syndrome. The progress in systems biology and specific animal models created possibilities to assess the effects of such preparations. Here we report the plasma and liver lipidomics results of the intervention effects of a preparation SUB885C in apolipoprotein E3 Leiden cholesteryl ester transfer protein (ApoE*3Leiden.CETP) mice. SUB885C was developed according to the principles of CM for treatment of metabolic syndrome. The cannabinoid receptor type 1 blocker rimonabant was included as a general control for the evaluation of weight and metabolic responses.
Language英语
WOS IDWOS:000301570600031
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/118279
Collection中国科学院大连化学物理研究所
Corresponding AuthorXu GW(许国旺); JanvanderGreef
Affiliation1.TNO, Dept Earth Environm & Life Sci, NL-3700 AJ Zeist, Netherlands
2.Sino Dutch Ctr Prevent & Personalized Med, Zeist, Netherlands
3.Leiden Univ, Leiden Amsterdam Ctr Drug Res, Div Analyt Biosci, Leiden, Netherlands
4.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
5.SU BioMed, Zeist, Netherlands
6.Fytagoras BV, Leiden, Netherlands
7.Leiden Univ, Netherlands Metabol Ctr, Leiden, Netherlands
8.Leiden Univ, Med Ctr, Dept Endocrinol & Cardiol, Leiden, Netherlands
9.Wageningen Univ, Div Human Nutr, Wageningen, Netherlands
Recommended Citation
GB/T 7714
Wei, Heng,Hu, Chunxiu,Wang, Mei,et al. Lipidomics Reveals Multiple Pathway Effects of a Multi-Components Preparation on Lipid Biochemistry in ApoE*3Leiden.CETP Mice[J]. PLOS ONE,2012,7(1):30332.
APA Wei, Heng.,Hu, Chunxiu.,Wang, Mei.,van den Hoek, Anita M..,Reijmers, Theo H..,...&JanvanderGreef.(2012).Lipidomics Reveals Multiple Pathway Effects of a Multi-Components Preparation on Lipid Biochemistry in ApoE*3Leiden.CETP Mice.PLOS ONE,7(1),30332.
MLA Wei, Heng,et al."Lipidomics Reveals Multiple Pathway Effects of a Multi-Components Preparation on Lipid Biochemistry in ApoE*3Leiden.CETP Mice".PLOS ONE 7.1(2012):30332.
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