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学科主题: 物理化学
题名: Lipidomics Reveals Multiple Pathway Effects of a Multi-Components Preparation on Lipid Biochemistry in ApoE*3Leiden.CETP Mice
作者: Wei, Heng1, 2;  Hu, Chunxiu3, 4;  Wang, Mei2, 5;  van den Hoek, Anita M.;  Reijmers, Theo H.3, 7;  Wopereis, Suzan1;  Bouwman, Jildau1, 7;  Ramaker, Raymond1;  Korthout, Henrie A. A. J.6;  Vennik, Marco6;  Hankemeier, Thomas3, 7;  Havekes, Louis M.8;  Witkamp, Renger F.9;  Verheij, Elwin R.1;  Xu, Guowang2, 4;  van der Greef, Jan1, 2, 3, 5
通讯作者: 许国旺 ;  JanvanderGreef
刊名: PLOS ONE
发表日期: 2012-01-23
DOI: 10.1371/journal.pone.0030332
卷: 7, 期:1, 页:30332
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1808
产权排名: 4,2
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
英文摘要: Background: Causes and consequences of the complex changes in lipids occurring in the metabolic syndrome are only partly understood. Several interconnected processes are deteriorating, which implies that multi-target approaches might be more successful than strategies based on a limited number of surrogate markers. Preparations from Chinese Medicine (CM) systems have been handed down with documented clinical features similar as metabolic syndrome, which might help developing new intervention for metabolic syndrome. The progress in systems biology and specific animal models created possibilities to assess the effects of such preparations. Here we report the plasma and liver lipidomics results of the intervention effects of a preparation SUB885C in apolipoprotein E3 Leiden cholesteryl ester transfer protein (ApoE*3Leiden.CETP) mice. SUB885C was developed according to the principles of CM for treatment of metabolic syndrome. The cannabinoid receptor type 1 blocker rimonabant was included as a general control for the evaluation of weight and metabolic responses.
关键词[WOS]: CHOLESTERYL ESTER TRANSFER ;  SYSTEMS BIOLOGY ;  APOE-ASTERISK-3-LEIDEN.CETP MICE ;  AGGRAVATES ATHEROSCLEROSIS ;  OVERWEIGHT PATIENTS ;  CHINESE MEDICINE ;  WEIGHT-REDUCTION ;  TRANSFER PROTEIN ;  HDL-CHOLESTEROL ;  TRANSGENIC MICE
语种: 英语
WOS记录号: WOS:000301570600031
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/118279
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.TNO, Dept Earth Environm & Life Sci, NL-3700 AJ Zeist, Netherlands
2.Sino Dutch Ctr Prevent & Personalized Med, Zeist, Netherlands
3.Leiden Univ, Leiden Amsterdam Ctr Drug Res, Div Analyt Biosci, Leiden, Netherlands
4.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
5.SU BioMed, Zeist, Netherlands
6.Fytagoras BV, Leiden, Netherlands
7.Leiden Univ, Netherlands Metabol Ctr, Leiden, Netherlands
8.Leiden Univ, Med Ctr, Dept Endocrinol & Cardiol, Leiden, Netherlands
9.Wageningen Univ, Div Human Nutr, Wageningen, Netherlands

Recommended Citation:
Wei, Heng,Hu, Chunxiu,Wang, Mei,et al. Lipidomics Reveals Multiple Pathway Effects of a Multi-Components Preparation on Lipid Biochemistry in ApoE*3Leiden.CETP Mice[J]. PLOS ONE,2012,7(1):30332.
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