中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
学科主题: 物理化学
题名: Comparative proteomic analysis of plasma from major depressive patients: identification of proteins associated with lipid metabolism and immunoregulation
作者: Xu, Hong-Bo1, 2, 3;  Zhang, Ru-Fang2, 3;  Luo, Dan1;  Zhou, Yuan4;  Wang, Ying1, 2, 3;  Fang, Liang3;  Li, Wen-Juan2, 3;  Mu, Jun1, 2, 3;  Zhang, Lihua4;  Zhang, Yukui4;  Xie, Peng1, 2, 3
通讯作者: 谢鹏
关键词: Biomarker ;  iTRAQ ;  major depressive disorder ;  plasma ;  proteomics
刊名: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
发表日期: 2012-11-01
DOI: 10.1017/S1461145712000302
卷: 15, 期:10, 页:1413-1425
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1810
产权排名: 4,4
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Clinical Neurology ;  Neurosciences ;  Pharmacology & Pharmacy ;  Psychiatry
研究领域[WOS]: Neurosciences & Neurology ;  Pharmacology & Pharmacy ;  Psychiatry
英文摘要: Major depressive disorder is a common neuropsychiatric disorder contributing to several socio-economic burdens including disability and suicide. As the underlying pathophysiology of major depressive disorder remains unclear, no objective test is yet available for aiding diagnosis or monitoring disease progression. To contribute to a better understanding of its pathogenesis, a comparative proteomic study was performed to identify proteins differentially expressed in plasma samples obtained from first-onset, treatment-naive depressed patients as compared to healthy controls. Samples from the two groups were immunodepleted of seven high-abundance proteins, labelled with isobaric tags for relative and absolute quantitation and then analysed by multi-dimensional liquid chromatography-tandem mass spectrometry. The proteomic results were further validated by immunoblotting or enzyme-linked immunoadsorbent assays and analysed with the MetaCore database. The results demonstrate that the functions of the altered proteins are primarily involved in lipid metabolism and immunoregulation. These findings suggest that early perturbation of lipid metabolism and immunoregulation may be involved in the pathophysiology of major depressive disorder.
关键词[WOS]: D-BINDING PROTEIN ;  APOB/APOA-I RATIO ;  APOLIPOPROTEIN-B ;  CARDIOVASCULAR-DISEASE ;  CERULOPLASMIN LEVELS ;  CEREBROSPINAL-FLUID ;  BIOMARKERS ;  STROKE ;  SCHIZOPHRENIA ;  LIPOPROTEINS
语种: 英语
WOS记录号: WOS:000309740200005
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/118292
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
2012btLu1RFIMg.PDF(328KB)----开放获取--View Download

作者单位: 1.Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing 400016, Peoples R China
2.Chongqing Key Lab Neurobiol, Chongqing, Peoples R China
3.Chongqing Med Univ, Inst Neurosci, Chongqing 400016, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China

Recommended Citation:
Xu, Hong-Bo,Zhang, Ru-Fang,Luo, Dan,et al. Comparative proteomic analysis of plasma from major depressive patients: identification of proteins associated with lipid metabolism and immunoregulation[J]. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY,2012,15(10):1413-1425.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Xu, Hong-Bo]'s Articles
 [Zhang, Ru-Fang]'s Articles
 [Luo, Dan]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Xu, Hong-Bo]‘s Articles
 [Zhang, Ru-Fang]‘s Articles
 [Luo, Dan]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
文件名: 2012btLu1RFIMg.PDF
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace