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学科主题: 物理化学
题名: A multi-omic map of the lipid-producing yeast Rhodosporidium toruloides
作者: Zhu, Zhiwei1, 2;  Zhang, Sufang1, 3;  Liu, Hongwei4;  Shen, Hongwei1, 3;  Lin, Xinping1, 2;  Yang, Fan1, 5;  Zhou, Yongjin J.1, 2;  Jin, Guojie1, 2;  Ye, Mingliang4;  Zou, Hanfan4;  Zhao, Zongbao K.1, 3
通讯作者: 邹汉法 ;  赵宗保
刊名: NATURE COMMUNICATIONS
发表日期: 2012-10-01
DOI: 10.1038/ncomms2112
卷: 3, 页:1112
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1816;1809
产权排名: 1, 1
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
英文摘要: Triacylglycerols are among the most attractive alternative raw materials for biofuel development. Current oil plant-based technologies are limited in terms of triacylglycerol production capacity and rate. These limitations may be circumvented by biotransformation of carbohydrates into lipids; however, our understanding of microbial oleaginicity remains limited. Here we present the results of a multi-omic analysis of Rhodosporidium toruloides, a robust triacylglycerol-producing fungus. The assembly of genome and transcriptome sequencing data reveals a genome of 20.2 M Mb containing 8,171 protein-coding genes, the majority of which have multiple introns. Genes including a novel fatty acid synthase are predicted to participate in metabolic pathways absent in non-oleaginous yeasts. Transcriptomic and proteomic data suggest that lipid accumulation under nitrogen-limited conditions correlates with the induction of lipogenesis, nitrogenous compound recycling, macromolecule metabolism and autophagy. The multi-omic map of R. toruloides therefore provides a valuable resource for efforts to rationally engineer lipid-production pathways.
关键词[WOS]: FATTY-ACID SYNTHASE ;  ATP-CITRATE LYASE ;  OLEAGINOUS YEAST ;  ASPERGILLUS-NIDULANS ;  MALIC ENZYME ;  RNA-SEQ ;  ACCUMULATION ;  METABOLISM ;  PURIFICATION ;  GENOME
语种: 英语
WOS记录号: WOS:000313514100022
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/118298
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
3.Dalian Natl Lab Clean Energy, Div Biomass Convers & Bioenergy, Dalian 116023, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
5.Dalian Polytech Univ, Sch Biol Engn, Dalian 116034, Peoples R China

Recommended Citation:
Zhu, Zhiwei,Zhang, Sufang,Liu, Hongwei,et al. A multi-omic map of the lipid-producing yeast Rhodosporidium toruloides[J]. NATURE COMMUNICATIONS,2012,3:1112.
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