DICP OpenIR
Subject Area物理化学
A multi-omic map of the lipid-producing yeast Rhodosporidium toruloides
Zhu, Zhiwei1,2; Zhang, Sufang1,3; Liu, Hongwei4; Shen, Hongwei1,3; Lin, Xinping1,2; Yang, Fan1,5; Zhou, Yongjin J.1,2; Jin, Guojie1,2; Ye, Mingliang4; Zou, Hanfan4; Zhao, Zongbao K.1,3; Zou HF(邹汉法); Zhao ZB(赵宗保)
Source PublicationNATURE COMMUNICATIONS
2012-10-01
ISSN2041-1723
DOI10.1038/ncomms2112
Volume3Pages:1112
Indexed BySCI
SubtypeArticle
Department18
Funding Project1816;1809
Contribution Rank1, 1
WOS HeadingsScience & Technology
WOS SubjectMultidisciplinary Sciences
WOS Research AreaScience & Technology - Other Topics
WOS KeywordFATTY-ACID SYNTHASE ; ATP-CITRATE LYASE ; OLEAGINOUS YEAST ; ASPERGILLUS-NIDULANS ; MALIC ENZYME ; RNA-SEQ ; ACCUMULATION ; METABOLISM ; PURIFICATION ; GENOME
AbstractTriacylglycerols are among the most attractive alternative raw materials for biofuel development. Current oil plant-based technologies are limited in terms of triacylglycerol production capacity and rate. These limitations may be circumvented by biotransformation of carbohydrates into lipids; however, our understanding of microbial oleaginicity remains limited. Here we present the results of a multi-omic analysis of Rhodosporidium toruloides, a robust triacylglycerol-producing fungus. The assembly of genome and transcriptome sequencing data reveals a genome of 20.2 M Mb containing 8,171 protein-coding genes, the majority of which have multiple introns. Genes including a novel fatty acid synthase are predicted to participate in metabolic pathways absent in non-oleaginous yeasts. Transcriptomic and proteomic data suggest that lipid accumulation under nitrogen-limited conditions correlates with the induction of lipogenesis, nitrogenous compound recycling, macromolecule metabolism and autophagy. The multi-omic map of R. toruloides therefore provides a valuable resource for efforts to rationally engineer lipid-production pathways.
Language英语
WOS IDWOS:000313514100022
Citation statistics
Cited Times:154[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/118298
Collection中国科学院大连化学物理研究所
Corresponding AuthorZou HF(邹汉法); Zhao ZB(赵宗保)
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
3.Dalian Natl Lab Clean Energy, Div Biomass Convers & Bioenergy, Dalian 116023, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
5.Dalian Polytech Univ, Sch Biol Engn, Dalian 116034, Peoples R China
Recommended Citation
GB/T 7714
Zhu, Zhiwei,Zhang, Sufang,Liu, Hongwei,et al. A multi-omic map of the lipid-producing yeast Rhodosporidium toruloides[J]. NATURE COMMUNICATIONS,2012,3:1112.
APA Zhu, Zhiwei.,Zhang, Sufang.,Liu, Hongwei.,Shen, Hongwei.,Lin, Xinping.,...&赵宗保.(2012).A multi-omic map of the lipid-producing yeast Rhodosporidium toruloides.NATURE COMMUNICATIONS,3,1112.
MLA Zhu, Zhiwei,et al."A multi-omic map of the lipid-producing yeast Rhodosporidium toruloides".NATURE COMMUNICATIONS 3(2012):1112.
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