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学科主题: 物理化学
题名: The potential of metabolic fingerprinting as a tool for the modernisation of TCM preparations
作者: Sheridan, Helen2;  Krenn, Liselotte3;  Jiang, Renwang4;  Sutherland, Ian5;  Ignatova, Svetlana5;  Marmann, Andreas6;  Liang, Xinmiao7;  Sendker, Jandirk1
通讯作者: SendkerJandirk
关键词: Chinese herbal medicines ;  Extraction ;  Compound analysis ;  Metabolomics ;  Fingerprint analysis
刊名: JOURNAL OF ETHNOPHARMACOLOGY
发表日期: 2012-04-10
DOI: 10.1016/j.jep.2012.01.050
卷: 140, 期:3, 页:482-491
收录类别: SCI
文章类型: Review
部门归属: 18
项目归属: 1803
产权排名: 6,7
类目[WOS]: Plant Sciences ;  Chemistry, Medicinal ;  Integrative & Complementary Medicine ;  Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ;  Pharmacology & Pharmacy ;  Integrative & Complementary Medicine
英文摘要: A vast majority Chinese herbal medicines (CHM) are traditionally administered as individually prepared water decoctions (tang) which are rather complicated in practice and their dry extracts show technological problems that hamper straight production of more convenient application forms. Modernised extraction procedures may overcome these difficulties but there is lack of clinical evidence supporting their therapeutic equivalence to traditional decoctions and their quality can often not solely be attributed to the single marker compounds that are usually used for chemical extract optimisation. As demonstrated by the example of the rather simple traditional TCM formula Danggui Buxue Tang, both the chemical composition and the biological activity of extracts resulting from traditional water decoction are influenced by details of the extraction procedure and especially involve pharmacokinetic synergism based on co-extraction. Hence, a more detailed knowledge about the traditional extracts' chemical profiles and their impact on biological activity is desirable in order to allow the development of modernised extracts that factually contain the whole range of compounds relevant for the efficacy of the traditional application. We propose that these compounds can be identified by metabolomics based on comprehensive fingerprint analysis of different extracts with known biological activity. TCM offers a huge variety of traditional products of the same botanical origin but with distinct therapeutic properties, like differentially processed drugs and special daodi qualities. Through this variety, TCM gives an ideal field for the application of metabolomic techniques aiming at the identification of active constituents. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
关键词[WOS]: COUNTER-CURRENT CHROMATOGRAPHY ;  TRADITIONAL CHINESE MEDICINES ;  NMR-BASED METABOLOMICS ;  MAGNETIC-RESONANCE-SPECTROSCOPY ;  RADIX-ANGELICAE-SINENSIS ;  SUPERCRITICAL-FLUID EXTRACTION ;  NATURAL-PRODUCT LIBRARIES ;  ORTHOGONAL ARRAY DESIGN ;  DANGGUI BUXUE TANG ;  HERBAL DECOCTION
语种: 英语
WOS记录号: WOS:000302844100005
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/118328
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Univ Munster, Inst Pharmaceut Biol & Phytochem, D-48149 Munster, Germany
2.Trinity Coll Dublin, Sch Pharm & Pharmaceut Sci, Dublin 2, Ireland
3.Univ Vienna, Dept Pharmacognosy, A-1090 Vienna, Austria
4.Jinan Univ, Guangdong Prov Key Lab Pharmacodynam Constituents, Coll Pharm, Guangzhou 510632, Guangdong, Peoples R China
5.Brunel Univ, Brunel Inst Bioengn, Uxbridge UB8 3PH, Middx, England
6.Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, D-40225 Dusseldorf, Germany
7.Chinese Acad Sci, Dalian Inst Chem Phys, Dept Biotechnol, Dalian 116023, Peoples R China

Recommended Citation:
Sheridan, Helen,Krenn, Liselotte,Jiang, Renwang,et al. The potential of metabolic fingerprinting as a tool for the modernisation of TCM preparations[J]. JOURNAL OF ETHNOPHARMACOLOGY,2012,140(3):482-491.
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