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学科主题: 物理化学
题名: Serum metabolomics reveals the deregulation of fatty acids metabolism in hepatocellular carcinoma and chronic liver diseases
作者: Zhou, Lina1;  Wang, Quancai2;  Yin, Peiyuan1;  Xing, Wenbin3;  Wu, Zeming1;  Chen, Shili1;  Lu, Xin1;  Zhang, Yong3;  Lin, Xiaohui2;  Xu, Guowang1
通讯作者: 许国旺 ;  林晓慧
关键词: Hepatocellular carcinoma ;  Metabolomic profiling ;  Random forest-recursive feature elimination ;  Acylcarnitine ;  Fatty acid oxidation
刊名: ANALYTICAL AND BIOANALYTICAL CHEMISTRY
发表日期: 2012-04-01
DOI: 10.1007/s00216-012-5782-4
卷: 403, 期:1, 页:203-213
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1808
产权排名: 1,1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: Patients with chronic liver diseases (CLD) including chronic hepatitis B and hepatic cirrhosis (CIR) are the major high-risk population of hepatocellular carcinoma (HCC). The differential diagnosis between CLD and HCC is a challenge. This work aims to study the related metabolic deregulations in HCC and CLD to promote the discovery of the differential metabolites for distinguishing the different liver diseases. Serum metabolic profiling analysis from patients with CLD and HCC was performed using a liquid chromatography-mass spectrometry system. The acquired large amount of metabolic information was processed with the random forest-recursive feature elimination method to discover important metabolic changes. It was found that long-chain acylcarnitines accumulated, whereas free carnitine, medium and short-chain acylcarnitines decreased with the severity of the non-malignant liver diseases, accompanied with corresponding alterations of enzyme activities. However, the general changing extent was smaller in HCC than in CIR, possibly due to the special energy-consumption mechanism of tumor cells. These observations may help to understand the mechanism of HCC occurrence and progression on the metabolic level and provide information for the identification of early and differential metabolic markers for HCC.
关键词[WOS]: MASS-SPECTROMETRY ;  INDOLEAMINE 2,3-DIOXYGENASE ;  RANDOM FOREST ;  MOLECULAR PATHOGENESIS ;  INTERFERON-GAMMA ;  VIRUS-INFECTION ;  CLASSIFICATION ;  IDENTIFICATION ;  METABONOMICS ;  PATHWAY
语种: 英语
WOS记录号: WOS:000301839700015
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/118343
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Dalian Univ Technol, Sch Comp Sci & Technol, Dalian 116024, Peoples R China
3.Sixth Peoples Hosp, Dalian 116001, Peoples R China

Recommended Citation:
Zhou, Lina,Wang, Quancai,Yin, Peiyuan,et al. Serum metabolomics reveals the deregulation of fatty acids metabolism in hepatocellular carcinoma and chronic liver diseases[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2012,403(1):203-213.
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