DICP OpenIR
Subject Area物理化学
Serum metabolomics reveals the deregulation of fatty acids metabolism in hepatocellular carcinoma and chronic liver diseases
Zhou, Lina1; Wang, Quancai2; Yin, Peiyuan1; Xing, Wenbin3; Wu, Zeming1; Chen, Shili1; Lu, Xin1; Zhang, Yong3; Lin, Xiaohui2; Xu, Guowang1; Xu GW(许国旺); Lin XH(林晓慧)
KeywordHepatocellular Carcinoma Metabolomic Profiling Random Forest-recursive Feature Elimination Acylcarnitine Fatty Acid Oxidation
Source PublicationANALYTICAL AND BIOANALYTICAL CHEMISTRY
2012-04-01
DOI10.1007/s00216-012-5782-4
Volume403Issue:1Pages:203-213
Indexed BySCI
SubtypeArticle
Department18
Funding Project1808
Contribution Rank1,1
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectBiochemical Research Methods ; Chemistry, Analytical
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS KeywordMASS-SPECTROMETRY ; INDOLEAMINE 2,3-DIOXYGENASE ; RANDOM FOREST ; MOLECULAR PATHOGENESIS ; INTERFERON-GAMMA ; VIRUS-INFECTION ; CLASSIFICATION ; IDENTIFICATION ; METABONOMICS ; PATHWAY
AbstractPatients with chronic liver diseases (CLD) including chronic hepatitis B and hepatic cirrhosis (CIR) are the major high-risk population of hepatocellular carcinoma (HCC). The differential diagnosis between CLD and HCC is a challenge. This work aims to study the related metabolic deregulations in HCC and CLD to promote the discovery of the differential metabolites for distinguishing the different liver diseases. Serum metabolic profiling analysis from patients with CLD and HCC was performed using a liquid chromatography-mass spectrometry system. The acquired large amount of metabolic information was processed with the random forest-recursive feature elimination method to discover important metabolic changes. It was found that long-chain acylcarnitines accumulated, whereas free carnitine, medium and short-chain acylcarnitines decreased with the severity of the non-malignant liver diseases, accompanied with corresponding alterations of enzyme activities. However, the general changing extent was smaller in HCC than in CIR, possibly due to the special energy-consumption mechanism of tumor cells. These observations may help to understand the mechanism of HCC occurrence and progression on the metabolic level and provide information for the identification of early and differential metabolic markers for HCC.
Language英语
WOS IDWOS:000301839700015
Citation statistics
Cited Times:86[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/118343
Collection中国科学院大连化学物理研究所
Corresponding AuthorXu GW(许国旺); Lin XH(林晓慧)
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Dalian Univ Technol, Sch Comp Sci & Technol, Dalian 116024, Peoples R China
3.Sixth Peoples Hosp, Dalian 116001, Peoples R China
Recommended Citation
GB/T 7714
Zhou, Lina,Wang, Quancai,Yin, Peiyuan,et al. Serum metabolomics reveals the deregulation of fatty acids metabolism in hepatocellular carcinoma and chronic liver diseases[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2012,403(1):203-213.
APA Zhou, Lina.,Wang, Quancai.,Yin, Peiyuan.,Xing, Wenbin.,Wu, Zeming.,...&林晓慧.(2012).Serum metabolomics reveals the deregulation of fatty acids metabolism in hepatocellular carcinoma and chronic liver diseases.ANALYTICAL AND BIOANALYTICAL CHEMISTRY,403(1),203-213.
MLA Zhou, Lina,et al."Serum metabolomics reveals the deregulation of fatty acids metabolism in hepatocellular carcinoma and chronic liver diseases".ANALYTICAL AND BIOANALYTICAL CHEMISTRY 403.1(2012):203-213.
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