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学科主题: 物理化学
题名: Highly stable high performance liquid chromatography stationary phase based on direct chemical modification of organic bridges in hybrid silica
作者: Yu, Hui1;  Jia, Cunyu1;  Wu, Haibo1;  Song, Guangjun1;  Jin, Yu1;  Ke, Yanxiong1;  Liang, Xinmiao2
通讯作者: 柯燕雄 ;  梁鑫淼
关键词: Hybrid silica ;  Stationary phase ;  1,4-Dimethoxybenzene-bridged ;  Reversed phase ;  Chromatography
刊名: JOURNAL OF CHROMATOGRAPHY A
发表日期: 2012-07-20
DOI: 10.1016/j.chroma.2012.05.062
卷: 1247, 页:63-70
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1803
产权排名: 2,7
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: Highly monodisperse 1,4-dimethoxybenzene-bridged organic/inorganic hybrid mesoporous spheres were synthesized by condensation of 1.4-dimethoxy-2,5-bis(triethoxysilyl)benzene using dodecylamine (DDA) and cetyltrimethylammonium bromide (CTAB) as co-templates. The spherical hybrid particles, which have specific surface area of 509 m(2)/g, pore volume of 0.8 cm(3)/g and average pore size of 63 A, were characterized by elemental analysis. SEM, TEM, small angel X-ray scattering, Raman, FT-IR and nitrogen adsorption-desorption analysis. The hybrid material was further chemically modified with C12 chain group via formation of C-O-R bond, which is believed to be far more stable than traditional Si-O-Si bonding type at low pH condition. At the same time, the hybrid silica substrate has been proved to possess the improved chemical stability at high pH. In this way, combination of the hybrid silica substrate and this advanced modification method enable the stationary phase to be used in extended pH range. The chemical stability of this surface modified 1,4-dimethoxybenzene-bridged hybrid stationary phase was evaluated both at low pH (pH = 0.95) and high pH (pH = 11.0). Some acidic and alkaline pH chromatographic evaluations were performed to illustrate the advantages of the improved chemical stability of this packing material. (c) 2012 Elsevier B.V. All rights reserved.
关键词[WOS]: MIXED TRIFUNCTIONAL SILANES ;  BASIC COMPOUNDS ;  HORIZONTAL POLYMERIZATION ;  BONDED PHASES ;  MOBILE PHASES ;  HIGH PH ;  COLUMNS ;  SEPARATIONS ;  PARTICLES ;  STABILITY
语种: 英语
WOS记录号: WOS:000306246100009
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/118394
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.E China Univ Sci & Technol, Sch Pharm, Minist Educ, Engn Res Ctr Pharmaceut Proc Chem, Shanghai 200237, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

Recommended Citation:
Yu, Hui,Jia, Cunyu,Wu, Haibo,et al. Highly stable high performance liquid chromatography stationary phase based on direct chemical modification of organic bridges in hybrid silica[J]. JOURNAL OF CHROMATOGRAPHY A,2012,1247:63-70.
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