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学科主题物理化学
Highly stable high performance liquid chromatography stationary phase based on direct chemical modification of organic bridges in hybrid silica
Yu, Hui1; Jia, Cunyu1; Wu, Haibo1; Song, Guangjun1; Jin, Yu1; Ke, Yanxiong1; Liang, Xinmiao2; Ke YX(柯燕雄); Liang XM(梁鑫淼)
关键词Hybrid Silica Stationary Phase Reversed Phase 1 Chromatography 4-dimethoxybenzene-bridged
刊名JOURNAL OF CHROMATOGRAPHY A
2012-07-20
ISSN0021-9673
DOI10.1016/j.chroma.2012.05.062
1247页:63-70
收录类别SCI
文章类型Article
部门归属18
项目归属1803
产权排名2,7
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]MIXED TRIFUNCTIONAL SILANES ; BASIC COMPOUNDS ; HORIZONTAL POLYMERIZATION ; BONDED PHASES ; MOBILE PHASES ; HIGH PH ; COLUMNS ; SEPARATIONS ; PARTICLES ; STABILITY
英文摘要Highly monodisperse 1,4-dimethoxybenzene-bridged organic/inorganic hybrid mesoporous spheres were synthesized by condensation of 1.4-dimethoxy-2,5-bis(triethoxysilyl)benzene using dodecylamine (DDA) and cetyltrimethylammonium bromide (CTAB) as co-templates. The spherical hybrid particles, which have specific surface area of 509 m(2)/g, pore volume of 0.8 cm(3)/g and average pore size of 63 A, were characterized by elemental analysis. SEM, TEM, small angel X-ray scattering, Raman, FT-IR and nitrogen adsorption-desorption analysis. The hybrid material was further chemically modified with C12 chain group via formation of C-O-R bond, which is believed to be far more stable than traditional Si-O-Si bonding type at low pH condition. At the same time, the hybrid silica substrate has been proved to possess the improved chemical stability at high pH. In this way, combination of the hybrid silica substrate and this advanced modification method enable the stationary phase to be used in extended pH range. The chemical stability of this surface modified 1,4-dimethoxybenzene-bridged hybrid stationary phase was evaluated both at low pH (pH = 0.95) and high pH (pH = 11.0). Some acidic and alkaline pH chromatographic evaluations were performed to illustrate the advantages of the improved chemical stability of this packing material. (c) 2012 Elsevier B.V. All rights reserved.
语种英语
WOS记录号WOS:000306246100009
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/118394
专题中国科学院大连化学物理研究所
通讯作者Ke YX(柯燕雄); Liang XM(梁鑫淼)
作者单位1.E China Univ Sci & Technol, Sch Pharm, Minist Educ, Engn Res Ctr Pharmaceut Proc Chem, Shanghai 200237, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
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Yu, Hui,Jia, Cunyu,Wu, Haibo,et al. Highly stable high performance liquid chromatography stationary phase based on direct chemical modification of organic bridges in hybrid silica[J]. JOURNAL OF CHROMATOGRAPHY A,2012,1247:63-70.
APA Yu, Hui.,Jia, Cunyu.,Wu, Haibo.,Song, Guangjun.,Jin, Yu.,...&梁鑫淼.(2012).Highly stable high performance liquid chromatography stationary phase based on direct chemical modification of organic bridges in hybrid silica.JOURNAL OF CHROMATOGRAPHY A,1247,63-70.
MLA Yu, Hui,et al."Highly stable high performance liquid chromatography stationary phase based on direct chemical modification of organic bridges in hybrid silica".JOURNAL OF CHROMATOGRAPHY A 1247(2012):63-70.
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