DICP OpenIR
Subject Area物理化学
Highly stable high performance liquid chromatography stationary phase based on direct chemical modification of organic bridges in hybrid silica
Yu, Hui1; Jia, Cunyu1; Wu, Haibo1; Song, Guangjun1; Jin, Yu1; Ke, Yanxiong1; Liang, Xinmiao2; Ke YX(柯燕雄); Liang XM(梁鑫淼)
KeywordHybrid Silica Stationary Phase Reversed Phase 1 Chromatography 4-dimethoxybenzene-bridged
Source PublicationJOURNAL OF CHROMATOGRAPHY A
2012-07-20
ISSN0021-9673
DOI10.1016/j.chroma.2012.05.062
Volume1247Pages:63-70
Indexed BySCI
SubtypeArticle
Department18
Funding Project1803
Contribution Rank2,7
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine ; Physical Sciences
WOS SubjectBiochemical Research Methods ; Chemistry, Analytical
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS KeywordMIXED TRIFUNCTIONAL SILANES ; BASIC COMPOUNDS ; HORIZONTAL POLYMERIZATION ; BONDED PHASES ; MOBILE PHASES ; HIGH PH ; COLUMNS ; SEPARATIONS ; PARTICLES ; STABILITY
AbstractHighly monodisperse 1,4-dimethoxybenzene-bridged organic/inorganic hybrid mesoporous spheres were synthesized by condensation of 1.4-dimethoxy-2,5-bis(triethoxysilyl)benzene using dodecylamine (DDA) and cetyltrimethylammonium bromide (CTAB) as co-templates. The spherical hybrid particles, which have specific surface area of 509 m(2)/g, pore volume of 0.8 cm(3)/g and average pore size of 63 A, were characterized by elemental analysis. SEM, TEM, small angel X-ray scattering, Raman, FT-IR and nitrogen adsorption-desorption analysis. The hybrid material was further chemically modified with C12 chain group via formation of C-O-R bond, which is believed to be far more stable than traditional Si-O-Si bonding type at low pH condition. At the same time, the hybrid silica substrate has been proved to possess the improved chemical stability at high pH. In this way, combination of the hybrid silica substrate and this advanced modification method enable the stationary phase to be used in extended pH range. The chemical stability of this surface modified 1,4-dimethoxybenzene-bridged hybrid stationary phase was evaluated both at low pH (pH = 0.95) and high pH (pH = 11.0). Some acidic and alkaline pH chromatographic evaluations were performed to illustrate the advantages of the improved chemical stability of this packing material. (c) 2012 Elsevier B.V. All rights reserved.
Language英语
WOS IDWOS:000306246100009
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/118394
Collection中国科学院大连化学物理研究所
Corresponding AuthorKe YX(柯燕雄); Liang XM(梁鑫淼)
Affiliation1.E China Univ Sci & Technol, Sch Pharm, Minist Educ, Engn Res Ctr Pharmaceut Proc Chem, Shanghai 200237, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Yu, Hui,Jia, Cunyu,Wu, Haibo,et al. Highly stable high performance liquid chromatography stationary phase based on direct chemical modification of organic bridges in hybrid silica[J]. JOURNAL OF CHROMATOGRAPHY A,2012,1247:63-70.
APA Yu, Hui.,Jia, Cunyu.,Wu, Haibo.,Song, Guangjun.,Jin, Yu.,...&梁鑫淼.(2012).Highly stable high performance liquid chromatography stationary phase based on direct chemical modification of organic bridges in hybrid silica.JOURNAL OF CHROMATOGRAPHY A,1247,63-70.
MLA Yu, Hui,et al."Highly stable high performance liquid chromatography stationary phase based on direct chemical modification of organic bridges in hybrid silica".JOURNAL OF CHROMATOGRAPHY A 1247(2012):63-70.
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