中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
学科主题: 物理化学
题名: Metabolomics Study of Stepwise Hepatocarcinogenesis From the Model Rats to Patients: Potential Biomarkers Effective for Small Hepatocellular Carcinoma Diagnosis
作者: Tan, Yexiong2;  Yin, Peiyuan1;  Tang, Liang2;  Xing, Wenbin3;  Huang, Qiang1;  Cao, Dan2;  Zhao, Xinjie1;  Wang, Wenzhao1;  Lu, Xin1;  Xu, Zhiliang1;  Wang, Hongyang2;  Xu, Guowang1
通讯作者: HongyangWang ;  许国旺
刊名: MOLECULAR & CELLULAR PROTEOMICS
发表日期: 2012-02-01
DOI: 10.1074/mcp.M111.010694
卷: 11, 期:2, 页:106941
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1808
产权排名: 2,2
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biochemical Research Methods
研究领域[WOS]: Biochemistry & Molecular Biology
英文摘要: The aim of this study is to find the potential biomarkers from the rat hepatocellular carcinoma (HCC) disease model by using a non-target metabolomics method, and test their usefulness in early human HCC diagnosis. The serum metabolic profiling of the diethylnitrosamine-induced rat HCC model, which presents a stepwise histopathological progression that is similar to human HCC, was performed using liquid chromatography-mass spectrometry. Multivariate data analysis methods were utilized to identify the potential biomarkers. Three metabolites, taurocholic acid, lysophosphoethanolamine 16: 0, and lysophosphatidylcholine 22:5, were defined as "marker metabolites," which can be used to distinguish the different stages of chemical hepatocarcinogenesis. These metabolites represented the abnormal metabolism during the progress of hepatocarcinogenesis, which could also be found in patients. To test their diagnosis potential 412 sera from 262 patients with HCC, 76 patients with cirrhosis and 74 patients with chronic hepatitis B were collected and studied, it was found that 3 marker metabolites were effective for the discrimination of small liver tumor (solitary nodules of less than 2 cm in diameter) patients, achieved a sensitivity of 80.5% and a specificity of 80.1%, which is better than those of alpha-fetoprotein (53 and 64%, respectively). Moreover, they were also effective for the discrimination of all HCCs and chronic liver disease patients, which could achieve a sensitivity of 87.5% and a specificity of 72.3%, better than those of alpha-fetoprotein (61.2 and 64%). These results indicate metabolomics method has the potential of finding biomarkers for the early diagnosis of HCC. Molecular & Cellular Proteomics 11: 10.1074/mcp.M111.010694, 1-12, 2012.
关键词[WOS]: GAS CHROMATOGRAPHY/MASS SPECTROMETRY ;  METABONOMIC ANALYSIS ;  MASS-SPECTROMETRY ;  MOUSE MODEL ;  HPLC-MS ;  LIVER ;  CANCER ;  PROGRESSION ;  HEPATITIS ;  CARCINOGENESIS
语种: 英语
WOS记录号: WOS:000300056200011
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/118406
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
20124acqVvTbBS.PDF(3443KB)----开放获取--View Download

作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Second Mil Med Univ, Eastern Hepatobiliary Surg Inst, Int Cooperat Lab Signal Transduct, Shanghai, Peoples R China
3.Sixth Peoples Hosp Dalian, Dalian 116031, Peoples R China

Recommended Citation:
Tan, Yexiong,Yin, Peiyuan,Tang, Liang,et al. Metabolomics Study of Stepwise Hepatocarcinogenesis From the Model Rats to Patients: Potential Biomarkers Effective for Small Hepatocellular Carcinoma Diagnosis[J]. MOLECULAR & CELLULAR PROTEOMICS,2012,11(2):106941.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Tan, Yexiong]'s Articles
 [Yin, Peiyuan]'s Articles
 [Tang, Liang]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Tan, Yexiong]‘s Articles
 [Yin, Peiyuan]‘s Articles
 [Tang, Liang]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
文件名: 20124acqVvTbBS.PDF
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace