DICP OpenIR
Subject Area物理化学
Metabolomics Study of Stepwise Hepatocarcinogenesis From the Model Rats to Patients: Potential Biomarkers Effective for Small Hepatocellular Carcinoma Diagnosis
Tan, Yexiong2; Yin, Peiyuan1; Tang, Liang2; Xing, Wenbin3; Huang, Qiang1; Cao, Dan2; Zhao, Xinjie1; Wang, Wenzhao1; Lu, Xin1; Xu, Zhiliang1; Wang, Hongyang2; Xu, Guowang1; HongyangWang; Xu GW(许国旺)
Source PublicationMOLECULAR & CELLULAR PROTEOMICS
2012-02-01
DOI10.1074/mcp.M111.010694
Volume11Issue:2Pages:106941
Indexed BySCI
SubtypeArticle
Department18
Funding Project1808
Contribution Rank2,2
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS SubjectBiochemical Research Methods
WOS Research AreaBiochemistry & Molecular Biology
WOS KeywordGAS CHROMATOGRAPHY/MASS SPECTROMETRY ; METABONOMIC ANALYSIS ; MASS-SPECTROMETRY ; MOUSE MODEL ; HPLC-MS ; LIVER ; CANCER ; PROGRESSION ; HEPATITIS ; CARCINOGENESIS
AbstractThe aim of this study is to find the potential biomarkers from the rat hepatocellular carcinoma (HCC) disease model by using a non-target metabolomics method, and test their usefulness in early human HCC diagnosis. The serum metabolic profiling of the diethylnitrosamine-induced rat HCC model, which presents a stepwise histopathological progression that is similar to human HCC, was performed using liquid chromatography-mass spectrometry. Multivariate data analysis methods were utilized to identify the potential biomarkers. Three metabolites, taurocholic acid, lysophosphoethanolamine 16: 0, and lysophosphatidylcholine 22:5, were defined as "marker metabolites," which can be used to distinguish the different stages of chemical hepatocarcinogenesis. These metabolites represented the abnormal metabolism during the progress of hepatocarcinogenesis, which could also be found in patients. To test their diagnosis potential 412 sera from 262 patients with HCC, 76 patients with cirrhosis and 74 patients with chronic hepatitis B were collected and studied, it was found that 3 marker metabolites were effective for the discrimination of small liver tumor (solitary nodules of less than 2 cm in diameter) patients, achieved a sensitivity of 80.5% and a specificity of 80.1%, which is better than those of alpha-fetoprotein (53 and 64%, respectively). Moreover, they were also effective for the discrimination of all HCCs and chronic liver disease patients, which could achieve a sensitivity of 87.5% and a specificity of 72.3%, better than those of alpha-fetoprotein (61.2 and 64%). These results indicate metabolomics method has the potential of finding biomarkers for the early diagnosis of HCC. Molecular & Cellular Proteomics 11: 10.1074/mcp.M111.010694, 1-12, 2012.
Language英语
WOS IDWOS:000300056200011
Citation statistics
Cited Times:96[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/118406
Collection中国科学院大连化学物理研究所
Corresponding AuthorHongyangWang; Xu GW(许国旺)
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Second Mil Med Univ, Eastern Hepatobiliary Surg Inst, Int Cooperat Lab Signal Transduct, Shanghai, Peoples R China
3.Sixth Peoples Hosp Dalian, Dalian 116031, Peoples R China
Recommended Citation
GB/T 7714
Tan, Yexiong,Yin, Peiyuan,Tang, Liang,et al. Metabolomics Study of Stepwise Hepatocarcinogenesis From the Model Rats to Patients: Potential Biomarkers Effective for Small Hepatocellular Carcinoma Diagnosis[J]. MOLECULAR & CELLULAR PROTEOMICS,2012,11(2):106941.
APA Tan, Yexiong.,Yin, Peiyuan.,Tang, Liang.,Xing, Wenbin.,Huang, Qiang.,...&许国旺.(2012).Metabolomics Study of Stepwise Hepatocarcinogenesis From the Model Rats to Patients: Potential Biomarkers Effective for Small Hepatocellular Carcinoma Diagnosis.MOLECULAR & CELLULAR PROTEOMICS,11(2),106941.
MLA Tan, Yexiong,et al."Metabolomics Study of Stepwise Hepatocarcinogenesis From the Model Rats to Patients: Potential Biomarkers Effective for Small Hepatocellular Carcinoma Diagnosis".MOLECULAR & CELLULAR PROTEOMICS 11.2(2012):106941.
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