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学科主题: 物理化学
题名: Separation and identification of flavonoids from complex samples using off-line two-dimensional liquid chromatography tandem mass spectrometry
作者: Zeng, Jing1, 2;  Zhang, Xiuli1;  Guo, Zhimou1;  Feng, Jiatao1;  Zeng, Jianguo2;  Xue, Xingya1;  Liang, Xinmiao1
通讯作者: 薛兴亚 ;  梁鑫淼
关键词: Off-line two-dimensional liquid chromatography ;  Identification ;  Flavonoids ;  Library searching ;  Traditional Chinese Medicines
刊名: JOURNAL OF CHROMATOGRAPHY A
发表日期: 2012-01-13
DOI: 10.1016/j.chroma.2011.11.043
卷: 1220, 页:50-56
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1803
产权排名: 1,1
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: In this study, a LC-based identification strategy was proposed and off-line two-dimensional liquid chromatography was developed for the separation and identification of flavonoids from complex samples. The highly orthogonal separation system was composed of a CD column, an OEG column and an XTerra C-18 column. The CD column was employed for the first dimensional separation and the OEG column and XTerra C-18 column were used for the second dimensional separation in parallel. A mixture of six traditional Chinese medicines was used as a complex sample in testing this method. Unknown peaks were identified by matching their retention times and accurate mass molecular weights with those of references. The identification efficacy of parallel unidimensional liquid chromatography and off-line two-dimensional liquid chromatography was compared, and the latter was demonstrated to be more efficient for the identification of target compounds-especially co-eluted compounds or minor compounds from complex samples. (C) 2011 Elsevier B.V. All rights reserved.
关键词[WOS]: REVERSED-PHASE ;  OLIGO(ETHYLENE GLYCOL) ;  STATIONARY-PHASE ;  SELECTIVITY ;  TOXICOLOGY ;  SYSTEMS ;  SILICA ;  CLICK
语种: 英语
WOS记录号: WOS:000299586000008
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/118414
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Nat Med, Key Lab Separat Sci Analyt Chem, Dalian 116023, Liaoning Provin, Peoples R China
2.Hunan Agr Univ, Natl Res Ctr Engn Technol Utilizat Funct Ingredie, Changsha 410128, Hunan, Peoples R China

Recommended Citation:
Zeng, Jing,Zhang, Xiuli,Guo, Zhimou,et al. Separation and identification of flavonoids from complex samples using off-line two-dimensional liquid chromatography tandem mass spectrometry[J]. JOURNAL OF CHROMATOGRAPHY A,2012,1220:50-56.
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