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学科主题: 物理化学
题名: Metabolomic analysis reveals that carnitines are key regulatory metabolites in phase transition of the locusts
作者: Wu, Rui2;  Wu, Zeming1;  Wang, Xianhui2;  Yang, Pengcheng2;  Yu, Dan2;  Zhao, Chunxia1;  Xu, Guowang1;  Kang, Le2
通讯作者: 许国旺 ;  LeKang
关键词: aggregation ;  metabolic profiling ;  phase change
刊名: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
发表日期: 2012-02-28
DOI: 10.1073/pnas.1119155109
卷: 109, 期:9, 页:3259-3263
收录类别: SCI
文章类型: Article
部门归属: 18
项目归属: 1808
产权排名: 2,2
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
英文摘要: Phenotypic plasticity occurs prevalently and plays a vital role in adaptive evolution. However, the underlying molecular mechanisms responsible for the expression of alternate phenotypes remain unknown. Here, a density-dependent phase polyphenism of Locusta migratoria was used as the study model to identify key signaling molecules regulating the expression of phenotypic plasticity. Metabolomic analysis, using high-performance liquid chromatography and gas chromatography-mass spectrometry, showed that solitarious and gregarious locusts have distinct metabolic profiles in hemolymph. A total of 319 metabolites, many of which are involved in lipid metabolism, differed significantly in concentration between the phases. In addition, the time course of changes in the metabolic profiles of locust hemolymph that accompany phase transition was analyzed. Carnitine and its acyl derivatives, which are involved in the lipid beta-oxidation process, were identified as key differential metabolites that display robust correlation with the time courses of phase transition. RNAi silencing of two key enzymes from the carnitine system, carnitine acetyltransferase and palmitoyltransferase, resulted in a behavioral transition from the gregarious to solitarious phase and the corresponding changes of metabolic profiles. In contrast, the injection of exogenous acetylcarnitine promoted the acquisition of gregarious behavior in solitarious locusts. These results suggest that carnitines mediate locust phase transition possibly through modulating lipid metabolism and influencing the nervous system of the locusts.
关键词[WOS]: ACETYL-L-CARNITINE ;  RAT-BRAIN ;  BEHAVIOR ;  METHYLATION ;  INSECTS ;  TOOL
语种: 英语
WOS记录号: WOS:000300828200021
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/118435
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Inst Zool, State Key Lab Integrated Management Pest Insects, Beijing 100101, Peoples R China

Recommended Citation:
Wu, Rui,Wu, Zeming,Wang, Xianhui,et al. Metabolomic analysis reveals that carnitines are key regulatory metabolites in phase transition of the locusts[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2012,109(9):3259-3263.
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