DICP OpenIR
学科主题物理化学
Circulating Lysophosphatidylcholines Are Markers of a Metabolically Benign Nonalcoholic Fatty Liver
Lehmann, Rainer1,2; Franken, Holger3; Dammeier, Sascha4; Rosenbaum, Lars3; Kantartzis, Konstantinos1,2; Peter, Andreas1,2; Zell, Andreas3; Adam, Patrick5; Li, Jia6; Xu, Guowang6; Koenigsrainer, Alfred7; Machann, Juergen8; Schick, Fritz8; de Angelis, Martin Hrabe9; Schwab, Matthias10,11; Staiger, Harald1,2; Schleicher, Erwin1,2; Gastaldelli, Amalia12; Fritsche, Andreas1,2; Haering, Hans-Ulrich1,2; Stefan, Norbert1,2; Norbert Stefan
刊名DIABETES CARE
2013-08-01
DOI10.2337/dc12-1760
36期:8页:2331-2338
收录类别SCI
合作性质
文章类型Article
部门归属18
项目归属1808
产权排名待补充
WOS标题词Science & Technology ; Life Sciences & Biomedicine
资助者6,9 ; 6,9 ; 6,9 ; 6,9
类目[WOS]Endocrinology & Metabolism
研究领域[WOS]Endocrinology & Metabolism
关键词[WOS]REGULATORY T-CELLS ; LIFE-STYLE INTERVENTION ; INSULIN-RESISTANCE ; HEPATIC STEATOSIS ; DISEASE ; OBESITY ; HOMEOSTASIS ; RISK ; STEATOHEPATITIS ; MECHANISMS
英文摘要OBJECTIVENonalcoholic fatty liver (NAFL) is thought to contribute to insulin resistance and its metabolic complications. However, some individuals with NAFL remain insulin sensitive. Mechanisms involved in the susceptibility to develop insulin resistance in humans with NAFL are largely unknown. We investigated circulating markers and mechanisms of a metabolically benign and malignant NAFL by applying a metabolomic approach.RESEARCH DESIGN AND METHODSA total of 265 metabolites were analyzed before and after a 9-month lifestyle intervention in plasma from 20 insulin-sensitive and 20 insulin-resistant subjects with NAFL. The relevant plasma metabolites were then tested for relationships with insulin sensitivity in 17 subjects without NAFL and in plasma from 29 subjects with liver tissue samples.RESULTSThe best separation of the insulin-sensitive from the insulin-resistant NAFL group was achieved by a metabolite pattern including the branched-chain amino acids leucine and isoleucine, ornithine, the acylcarnitines C3:0-, C16:0-, and C18:0-carnitine, and lysophosphatidylcholine (lyso-PC) C16:0 (area under the ROC curve, 0.77 [P = 0.00023] at baseline and 0.80 [P = 0.000019] at follow-up). Among the individual metabolites, predominantly higher levels of lyso-PC C16:0, both at baseline (P = 0.0039) and at follow-up (P = 0.001), were found in the insulin-sensitive compared with the insulin-resistant subjects. In the non-NAFL groups, no differences in lyso-PC C16:0 levels were found between the insulin-sensitive and insulin-resistant subjects, and these relationships were replicated in plasma from subjects with liver tissue samples.CONCLUSIONSFrom a plasma metabolomic pattern, particularly lyso-PCs are able to separate metabolically benign from malignant NAFL in humans and may highlight important pathways in the pathogenesis of fatty liver-induced insulin resistance.
语种英语
资助者6,9 ; 6,9 ; 6,9 ; 6,9
原文出处查看原文
WOS记录号WOS:000327252600049
引用统计
被引频次:37[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/119130
专题中国科学院大连化学物理研究所
通讯作者Norbert Stefan
作者单位1.Univ Hosp Tubingen, Dept Internal Med, Div Endocrinol Diabetol Vasc Med Nephrol & Clin C, Tubingen, Germany
2.Univ Tubingen, Inst Diabet Res & Metab Dis, Tubingen, Germany
3.Univ Tubingen, Ctr Bioinformat, Tubingen, Germany
4.Univ Tubingen, Med Proteome Ctr, Inst Ophthalm Res, Tubingen, Germany
5.Univ Tubingen, Inst Pathol, Tubingen, Germany
6.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
7.Univ Tubingen, Dept Gen Visceral & Transplant Surg, Tubingen, Germany
8.Univ Tubingen, Sect Expt Radiol, Tubingen, Germany
9.Helmholtz Zentrum, Inst Expt Genet, Munich, Germany
10.Dr Margarete Fischer Bosch Inst Clin Pharmacol, Stuttgart, Germany
11.Univ Tubingen, Stuttgart, Germany
12.CNR, Inst Clin Physiol, Pisa, Italy
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GB/T 7714
Lehmann, Rainer,Franken, Holger,Dammeier, Sascha,et al. Circulating Lysophosphatidylcholines Are Markers of a Metabolically Benign Nonalcoholic Fatty Liver[J]. DIABETES CARE,2013,36(8):2331-2338.
APA Lehmann, Rainer.,Franken, Holger.,Dammeier, Sascha.,Rosenbaum, Lars.,Kantartzis, Konstantinos.,...&Norbert Stefan.(2013).Circulating Lysophosphatidylcholines Are Markers of a Metabolically Benign Nonalcoholic Fatty Liver.DIABETES CARE,36(8),2331-2338.
MLA Lehmann, Rainer,et al."Circulating Lysophosphatidylcholines Are Markers of a Metabolically Benign Nonalcoholic Fatty Liver".DIABETES CARE 36.8(2013):2331-2338.
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