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学科主题: 物理化学
题名: Biomimetic tumor microenvironment on a microfluidic platform
作者: Ma, Huipeng1;  Xu, Hui1;  Qin, Jianhua1
通讯作者: 秦建华
关键词: biochemistry ;  biological techniques ;  biomechanics ;  bioMEMS ;  biomimetics ;  cancer ;  cellular biophysics ;  drugs ;  large-scale systems ;  microfluidics ;  tumours
刊名: BIOMICROFLUIDICS
发表日期: 2013
DOI: 10.1063/1.4774070
卷: 7, 期:1, 页:011501
收录类别: SCI
合作性质: 
文章类型: Article
部门归属: 18
项目归属: 1807
产权排名: 待补充
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Biophysics ;  Nanoscience & Nanotechnology ;  Physics, Fluids & Plasmas
资助者: 1,1
研究领域[WOS]: Biochemistry & Molecular Biology ;  Biophysics ;  Science & Technology - Other Topics ;  Physics
英文摘要: Tumor microenvironment is a highly complex system consisting of non-cancerous cells, soluble factors, signaling molecules, extracellular matrix, and mechanical cues, which provides tumor cells with integrated biochemical and biophysical cues. It has been recognized as a significant regulator in cancer initiation, progression, metastasis, and drug resistance, which is becoming a crucial component of cancer biology. Modeling microenvironmental conditions of such complexity in vitro are particularly difficult and technically challenging. Significant advances in microfluidic technologies have offered an unprecedented opportunity to closely mimic the physiological microenvironment that is normally encountered by cancer cells in vivo. This review highlights the recent advances of microfluidic platform in recapitulating many aspects of tumor microenvironment from biochemical and biophysical regulations. The major events relevant in tumorigenesis, angiogenesis, and spread of cancer cells dependent on specific combinations of cell types and soluble factors present in microenvironmental niche are summarized. The questions and challenges that lie ahead if this field is expected to transform the future cancer research are addressed as well. (C) 2013 American Institute of Physics. [http://dx.doi.org/10.1063/1.4774070]
关键词[WOS]: CANCER-ASSOCIATED FIBROBLASTS ;  MESENCHYMAL STEM-CELLS ;  BREAST-CANCER ;  EXTRACELLULAR-MATRIX ;  INTERSTITIAL FLOW ;  IN-VITRO ;  STROMAL FIBROBLASTS ;  CULTURE SYSTEMS ;  BRAIN-TUMORS ;  MIGRATION
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000315597100005
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/119132
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

Recommended Citation:
Ma, Huipeng,Xu, Hui,Qin, Jianhua. Biomimetic tumor microenvironment on a microfluidic platform[J]. BIOMICROFLUIDICS,2013,7(1):011501.
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