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学科主题物理化学
A novel strategy to evaluate the quality of traditional Chinese medicine based on the correlation analysis of chemical fingerprint and biological effect
Wang, Jing1,2; Kong, Hongwei1; Yuan, Zimin2; Gao, Peng1; Dai, Weidong1; Hu, Chunxiu1; Lu, Xin1; Xu, Guowang1; Kong HW(孔宏伟); Xu GW(许国旺)
关键词Rehmanniae Glutinosa Metabolomics Quality Evaluation Correlation Analysis Chemical Fingerprint
刊名JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
2013-09-01
DOI10.1016/j.jpba.2013.04.035
83页:57-64
收录类别SCI
合作性质
文章类型Article
部门归属18
项目归属1808
产权排名待补充
WOS标题词Science & Technology ; Physical Sciences ; Life Sciences & Biomedicine
资助者1,1 ; 1,1 ; 1,1 ; 1,1
类目[WOS]Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]GLUTINOSA VAR PURPUREA ; REHMANNIA-GLUTINOSA ; PHENYLPROPANOID GLYCOSIDES ; IN-VITRO ; ABSOLUTE STEREOSTRUCTURES ; SALVIA-MILTIORRHIZA ; IRIDOID GLYCOSIDES ; MASS-SPECTROMETRY ; RADIX ; CHROMATOGRAPHY
英文摘要A novel strategy was developed to assess the quality of TCM (traditional Chinese medicine) based on the correlation analysis of the chemical fingerprint and biological effect. Using Rehmanniae glutinosa (RG) to treat the kidney yin deficiency as an example, chemical fingerprints of 27 RG samples were analyzed by liquid chromatography-mass spectrometry (LC-MS), and urinary metabolic profiling of RG treatment of kidney yin deficiency in rats was explored by using LC-MS. A correlation analysis between the chemical fingerprints and efficacy evaluation was developed to identify quality marker components to assess TCM quality. Thirty-four variables in chemical fingerprints were successfully defined to have a close relationship with the efficacy of RG. The validation test with a new RG sample indicated that these efficacy-related components could be used to evaluate the integral quality of RG accurately. Compared with conventional chemical fingerprint methodology, not only is the proposed approach a powerful tool to identify efficacy-related components for the quality evaluation of TCM, but the approach can also be used to predict the therapeutic efficacy of TCMs. (C) 2013 Elsevier B.V. All rights reserved.
语种英语
资助者1,1 ; 1,1 ; 1,1 ; 1,1
原文出处查看原文
WOS记录号WOS:000321085800008
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/119158
专题中国科学院大连化学物理研究所
通讯作者Kong HW(孔宏伟); Xu GW(许国旺)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Liaoning Univ Tradit Chinese Med, Coll Pharm, Dalian 116600, Peoples R China
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GB/T 7714
Wang, Jing,Kong, Hongwei,Yuan, Zimin,et al. A novel strategy to evaluate the quality of traditional Chinese medicine based on the correlation analysis of chemical fingerprint and biological effect[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2013,83:57-64.
APA Wang, Jing.,Kong, Hongwei.,Yuan, Zimin.,Gao, Peng.,Dai, Weidong.,...&许国旺.(2013).A novel strategy to evaluate the quality of traditional Chinese medicine based on the correlation analysis of chemical fingerprint and biological effect.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,83,57-64.
MLA Wang, Jing,et al."A novel strategy to evaluate the quality of traditional Chinese medicine based on the correlation analysis of chemical fingerprint and biological effect".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 83(2013):57-64.
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