中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
学科主题: 物理化学
题名: A novel strategy to evaluate the quality of traditional Chinese medicine based on the correlation analysis of chemical fingerprint and biological effect
作者: Wang, Jing1, 2;  Kong, Hongwei1;  Yuan, Zimin2;  Gao, Peng1;  Dai, Weidong1;  Hu, Chunxiu1;  Lu, Xin1;  Xu, Guowang1
通讯作者: 孔宏伟 ;  许国旺
关键词: Rehmanniae glutinosa ;  Metabolomics ;  Quality evaluation ;  Correlation analysis ;  Chemical fingerprint
刊名: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
发表日期: 2013-09-01
DOI: 10.1016/j.jpba.2013.04.035
卷: 83, 页:57-64
收录类别: SCI
合作性质: 
文章类型: Article
部门归属: 18
项目归属: 1808
产权排名: 待补充
WOS标题词: Science & Technology ;  Physical Sciences ;  Life Sciences & Biomedicine
类目[WOS]: Chemistry, Analytical ;  Pharmacology & Pharmacy
资助者: 1,1
研究领域[WOS]: Chemistry ;  Pharmacology & Pharmacy
英文摘要: A novel strategy was developed to assess the quality of TCM (traditional Chinese medicine) based on the correlation analysis of the chemical fingerprint and biological effect. Using Rehmanniae glutinosa (RG) to treat the kidney yin deficiency as an example, chemical fingerprints of 27 RG samples were analyzed by liquid chromatography-mass spectrometry (LC-MS), and urinary metabolic profiling of RG treatment of kidney yin deficiency in rats was explored by using LC-MS. A correlation analysis between the chemical fingerprints and efficacy evaluation was developed to identify quality marker components to assess TCM quality. Thirty-four variables in chemical fingerprints were successfully defined to have a close relationship with the efficacy of RG. The validation test with a new RG sample indicated that these efficacy-related components could be used to evaluate the integral quality of RG accurately. Compared with conventional chemical fingerprint methodology, not only is the proposed approach a powerful tool to identify efficacy-related components for the quality evaluation of TCM, but the approach can also be used to predict the therapeutic efficacy of TCMs. (C) 2013 Elsevier B.V. All rights reserved.
关键词[WOS]: GLUTINOSA VAR PURPUREA ;  REHMANNIA-GLUTINOSA ;  PHENYLPROPANOID GLYCOSIDES ;  IN-VITRO ;  ABSOLUTE STEREOSTRUCTURES ;  SALVIA-MILTIORRHIZA ;  IRIDOID GLYCOSIDES ;  MASS-SPECTROMETRY ;  RADIX ;  CHROMATOGRAPHY
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000321085800008
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/119158
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
20138xaX3mR5Kn.PDF(1075KB)----开放获取View Download

作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Liaoning Univ Tradit Chinese Med, Coll Pharm, Dalian 116600, Peoples R China

Recommended Citation:
Wang, Jing,Kong, Hongwei,Yuan, Zimin,et al. A novel strategy to evaluate the quality of traditional Chinese medicine based on the correlation analysis of chemical fingerprint and biological effect[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2013,83:57-64.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Wang, Jing]'s Articles
 [Kong, Hongwei]'s Articles
 [Yuan, Zimin]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Wang, Jing]‘s Articles
 [Kong, Hongwei]‘s Articles
 [Yuan, Zimin]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
文件名: 20138xaX3mR5Kn.PDF
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace