DICP OpenIR
Subject Area物理化学
A novel strategy to evaluate the quality of traditional Chinese medicine based on the correlation analysis of chemical fingerprint and biological effect
Wang, Jing1,2; Kong, Hongwei1; Yuan, Zimin2; Gao, Peng1; Dai, Weidong1; Hu, Chunxiu1; Lu, Xin1; Xu, Guowang1; Kong HW(孔宏伟); Xu GW(许国旺)
KeywordRehmanniae Glutinosa Metabolomics Quality Evaluation Correlation Analysis Chemical Fingerprint
Source PublicationJOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
2013-09-01
DOI10.1016/j.jpba.2013.04.035
Volume83Pages:57-64
Indexed BySCI
Cooperation Status
SubtypeArticle
Department18
Funding Project1808
Contribution Rank待补充
WOS HeadingsScience & Technology ; Physical Sciences ; Life Sciences & Biomedicine
Funding Organization1,1 ; 1,1 ; 1,1 ; 1,1
WOS SubjectChemistry, Analytical ; Pharmacology & Pharmacy
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS KeywordGLUTINOSA VAR PURPUREA ; REHMANNIA-GLUTINOSA ; PHENYLPROPANOID GLYCOSIDES ; IN-VITRO ; ABSOLUTE STEREOSTRUCTURES ; SALVIA-MILTIORRHIZA ; IRIDOID GLYCOSIDES ; MASS-SPECTROMETRY ; RADIX ; CHROMATOGRAPHY
AbstractA novel strategy was developed to assess the quality of TCM (traditional Chinese medicine) based on the correlation analysis of the chemical fingerprint and biological effect. Using Rehmanniae glutinosa (RG) to treat the kidney yin deficiency as an example, chemical fingerprints of 27 RG samples were analyzed by liquid chromatography-mass spectrometry (LC-MS), and urinary metabolic profiling of RG treatment of kidney yin deficiency in rats was explored by using LC-MS. A correlation analysis between the chemical fingerprints and efficacy evaluation was developed to identify quality marker components to assess TCM quality. Thirty-four variables in chemical fingerprints were successfully defined to have a close relationship with the efficacy of RG. The validation test with a new RG sample indicated that these efficacy-related components could be used to evaluate the integral quality of RG accurately. Compared with conventional chemical fingerprint methodology, not only is the proposed approach a powerful tool to identify efficacy-related components for the quality evaluation of TCM, but the approach can also be used to predict the therapeutic efficacy of TCMs. (C) 2013 Elsevier B.V. All rights reserved.
Language英语
Funding Organization1,1 ; 1,1 ; 1,1 ; 1,1
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WOS IDWOS:000321085800008
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/119158
Collection中国科学院大连化学物理研究所
Corresponding AuthorKong HW(孔宏伟); Xu GW(许国旺)
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Liaoning Univ Tradit Chinese Med, Coll Pharm, Dalian 116600, Peoples R China
Recommended Citation
GB/T 7714
Wang, Jing,Kong, Hongwei,Yuan, Zimin,et al. A novel strategy to evaluate the quality of traditional Chinese medicine based on the correlation analysis of chemical fingerprint and biological effect[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2013,83:57-64.
APA Wang, Jing.,Kong, Hongwei.,Yuan, Zimin.,Gao, Peng.,Dai, Weidong.,...&许国旺.(2013).A novel strategy to evaluate the quality of traditional Chinese medicine based on the correlation analysis of chemical fingerprint and biological effect.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,83,57-64.
MLA Wang, Jing,et al."A novel strategy to evaluate the quality of traditional Chinese medicine based on the correlation analysis of chemical fingerprint and biological effect".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 83(2013):57-64.
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