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学科主题: 物理化学
题名: DETERMINATION OF PLASMA AMINO ACID BIOMARKERS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY FOR DIAGNOSIS OF TYPE 2 DIABETES MELLITUS
作者: Han, Xiaofei1;  Xiao, Hongbin2;  Liu, Qingping1;  Zhang, Liangxiao2;  Yang, Qianxu2;  Zhao, Nan2;  Huang, Yuhong3;  Zhang, Deqin3
通讯作者: Xiaofei Han
关键词: Amino acid profile ;  Aminotransferase ;  HPLC ;  Lipid ;  Type 2 diabetes mellitus
刊名: ANALYTICAL LETTERS
发表日期: 2013-12-12
DOI: 10.1080/00032719.2013.814055
卷: 46, 期:18, 页:2813-2827
收录类别: SCI
合作性质: 
文章类型: Article
部门归属: 18
项目归属: 1804
产权排名: 待补充
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
资助者: 2,2
研究领域[WOS]: Chemistry
英文摘要: The use of the fasting plasma glucose and 2-h plasma glucose tolerance tests leads to under-diagnosis of type 2 diabetes mellitus. To explore the contribution of metabolites for diagnosis for type 2 diabetes, plasma targeted metabolites (including free amino acids, lipids, and two hepatic aminotransferases) of 95 subjects were determined by high performance liquid chromatography and routine clinical methods. Receiver operating characteristic curve analysis was employed to evaluate potential diagnosis models. Based on the processing of orthogonal partial least squares-discriminant analysis, five amino acids (lysine, aspartate acid, threonine, methionine, and alanine) and two lipids (low density lipoprotein-cholesterol and high density lipoprotein-cholesterol) were discovered as potential biomarkers of type 2 diabetes. The area under the receiver operating characteristic curve built by the combination of these biomarkers and fasting plasma glucose was 0.994, which is significantly higher than that of the latter alone (0.907). These findings indicate that simultaneous measurement of specific metabolites with fasting plasma glucose from a single blood test for screening type 2 diabetes might be a more sensitive and specific strategy and provide additional insight regarding disease pathophysiologic mechanisms.
关键词[WOS]: GLUCOSE-TOLERANCE TEST ;  METABOLITE PROFILES ;  LDL CHOLESTEROL ;  RISK-FACTORS ;  TESTS ;  POPULATION ;  CRITERIA ;  RELEASE ;  INSULIN
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000327180300002
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/119269
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Dalian Univ, Coll Bioengn, Key Lab Bioorgan Chem, Dalian 116622, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
3.Tianjin Univ Tradit Chinese Med, Tianjin, Peoples R China

Recommended Citation:
Han, Xiaofei,Xiao, Hongbin,Liu, Qingping,et al. DETERMINATION OF PLASMA AMINO ACID BIOMARKERS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY FOR DIAGNOSIS OF TYPE 2 DIABETES MELLITUS[J]. ANALYTICAL LETTERS,2013,46(18):2813-2827.
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