DICP OpenIR
Subject Area物理化学
DETERMINATION OF PLASMA AMINO ACID BIOMARKERS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY FOR DIAGNOSIS OF TYPE 2 DIABETES MELLITUS
Han, Xiaofei1; Xiao, Hongbin2; Liu, Qingping1; Zhang, Liangxiao2; Yang, Qianxu2; Zhao, Nan2; Huang, Yuhong3; Zhang, Deqin3; Xiaofei Han
KeywordAmino Acid Profile Aminotransferase Hplc Lipid Type 2 Diabetes Mellitus
Source PublicationANALYTICAL LETTERS
2013-12-12
DOI10.1080/00032719.2013.814055
Volume46Issue:18Pages:2813-2827
Indexed BySCI
Cooperation Status
SubtypeArticle
Department18
Funding Project1804
Contribution Rank待补充
WOS HeadingsScience & Technology ; Physical Sciences
Funding Organization2,2 ; 2,2 ; 2,2 ; 2,2
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordGLUCOSE-TOLERANCE TEST ; METABOLITE PROFILES ; LDL CHOLESTEROL ; RISK-FACTORS ; TESTS ; POPULATION ; CRITERIA ; RELEASE ; INSULIN
AbstractThe use of the fasting plasma glucose and 2-h plasma glucose tolerance tests leads to under-diagnosis of type 2 diabetes mellitus. To explore the contribution of metabolites for diagnosis for type 2 diabetes, plasma targeted metabolites (including free amino acids, lipids, and two hepatic aminotransferases) of 95 subjects were determined by high performance liquid chromatography and routine clinical methods. Receiver operating characteristic curve analysis was employed to evaluate potential diagnosis models. Based on the processing of orthogonal partial least squares-discriminant analysis, five amino acids (lysine, aspartate acid, threonine, methionine, and alanine) and two lipids (low density lipoprotein-cholesterol and high density lipoprotein-cholesterol) were discovered as potential biomarkers of type 2 diabetes. The area under the receiver operating characteristic curve built by the combination of these biomarkers and fasting plasma glucose was 0.994, which is significantly higher than that of the latter alone (0.907). These findings indicate that simultaneous measurement of specific metabolites with fasting plasma glucose from a single blood test for screening type 2 diabetes might be a more sensitive and specific strategy and provide additional insight regarding disease pathophysiologic mechanisms.
Language英语
Funding Organization2,2 ; 2,2 ; 2,2 ; 2,2
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WOS IDWOS:000327180300002
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/119269
Collection中国科学院大连化学物理研究所
Corresponding AuthorXiaofei Han
Affiliation1.Dalian Univ, Coll Bioengn, Key Lab Bioorgan Chem, Dalian 116622, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
3.Tianjin Univ Tradit Chinese Med, Tianjin, Peoples R China
Recommended Citation
GB/T 7714
Han, Xiaofei,Xiao, Hongbin,Liu, Qingping,et al. DETERMINATION OF PLASMA AMINO ACID BIOMARKERS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY FOR DIAGNOSIS OF TYPE 2 DIABETES MELLITUS[J]. ANALYTICAL LETTERS,2013,46(18):2813-2827.
APA Han, Xiaofei.,Xiao, Hongbin.,Liu, Qingping.,Zhang, Liangxiao.,Yang, Qianxu.,...&Xiaofei Han.(2013).DETERMINATION OF PLASMA AMINO ACID BIOMARKERS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY FOR DIAGNOSIS OF TYPE 2 DIABETES MELLITUS.ANALYTICAL LETTERS,46(18),2813-2827.
MLA Han, Xiaofei,et al."DETERMINATION OF PLASMA AMINO ACID BIOMARKERS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY FOR DIAGNOSIS OF TYPE 2 DIABETES MELLITUS".ANALYTICAL LETTERS 46.18(2013):2813-2827.
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