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学科主题: 物理化学
题名: Microfluidic Device for Controllable Chemical Release via Field-Actuated Membrane Incorporating Nanoparticles
作者: Wang, Xiang1;  Li, Shunbo2, 3;  Wang, Limu1;  Yi, Xin1;  Hui, Yu Sanna1;  Qin, Jianhua4;  Wen, Weijia1, 2, 3
通讯作者: Weijia Wen
刊名: JOURNAL OF NANOMATERIALS
发表日期: 2013
DOI: 10.1155/2013/864584
卷: 2013, 页:864584
收录类别: SCI
合作性质: 
文章类型: Article
部门归属: 18
项目归属: 1807
产权排名: 待补充
WOS标题词: Science & Technology ;  Technology
类目[WOS]: Nanoscience & Nanotechnology ;  Materials Science, Multidisciplinary
资助者: 3,6
研究领域[WOS]: Science & Technology - Other Topics ;  Materials Science
英文摘要: We report a robust magnetic-membrane-based microfluidic platform for controllable chemical release. The magnetic membrane was prepared by mixing polydimethylsiloxane (PDMS) and carbonyl-iron nanoparticles together to obtain a flexible thin film. With combined, simultaneous regulation of magnetic stimulus and mechanical pumping, the desired chemical release rate can easily be realized. For example, the dose release experimental data was well fitted by a mathematical sigmoidal model, exhibiting a typical dose-response relationship, which shows promise in providing significant guidance for on-demand drug delivery. To test the platform's feasibility, our microfluidic device was employed in an experiment involving Escherichia coli culture under controlled antibiotic ciprofloxacin exposure, and the expected outcomes were successfully obtained. Our experimental results indicate that such a microfluidic device, with high accuracy and easy manipulation properties, can legitimately be characterized as active chemical release system.
关键词[WOS]: DRUG-DELIVERY ;  MICROCAPSULES ;  FABRICATION ;  MICRONEEDLES ;  DESIGN
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000325321100001
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/119274
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Hong Kong Univ Sci & Technol, Nanosci & Nanotechnol Program, Kowloon, Hong Kong, Peoples R China
2.Hong Kong Univ Sci & Technol, Dept Phys, Kowloon, Hong Kong, Peoples R China
3.Hong Kong Univ Sci & Technol, KAUST HKUST Joint Micro Nanofluid Lab, Kowloon, Hong Kong, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China

Recommended Citation:
Wang, Xiang,Li, Shunbo,Wang, Limu,et al. Microfluidic Device for Controllable Chemical Release via Field-Actuated Membrane Incorporating Nanoparticles[J]. JOURNAL OF NANOMATERIALS,2013,2013:864584.
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