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学科主题物理化学
Microfluidic Device for Controllable Chemical Release via Field-Actuated Membrane Incorporating Nanoparticles
Wang, Xiang1; Li, Shunbo2,3; Wang, Limu1; Yi, Xin1; Hui, Yu Sanna1; Qin, Jianhua4; Wen, Weijia1,2,3; Weijia Wen
刊名JOURNAL OF NANOMATERIALS
2013
ISSN1687--4110
DOI10.1155/2013/864584
2013页:864584
收录类别SCI
合作性质
文章类型Article
部门归属18
项目归属1807
产权排名待补充
WOS标题词Science & Technology ; Technology
资助者3,6 ; 3,6 ; 3,6 ; 3,6
类目[WOS]Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
研究领域[WOS]Science & Technology - Other Topics ; Materials Science
关键词[WOS]DRUG-DELIVERY ; MICROCAPSULES ; FABRICATION ; MICRONEEDLES ; DESIGN
英文摘要We report a robust magnetic-membrane-based microfluidic platform for controllable chemical release. The magnetic membrane was prepared by mixing polydimethylsiloxane (PDMS) and carbonyl-iron nanoparticles together to obtain a flexible thin film. With combined, simultaneous regulation of magnetic stimulus and mechanical pumping, the desired chemical release rate can easily be realized. For example, the dose release experimental data was well fitted by a mathematical sigmoidal model, exhibiting a typical dose-response relationship, which shows promise in providing significant guidance for on-demand drug delivery. To test the platform's feasibility, our microfluidic device was employed in an experiment involving Escherichia coli culture under controlled antibiotic ciprofloxacin exposure, and the expected outcomes were successfully obtained. Our experimental results indicate that such a microfluidic device, with high accuracy and easy manipulation properties, can legitimately be characterized as active chemical release system.
语种英语
资助者3,6 ; 3,6 ; 3,6 ; 3,6
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WOS记录号WOS:000325321100001
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/119274
专题中国科学院大连化学物理研究所
通讯作者Weijia Wen
作者单位1.Hong Kong Univ Sci & Technol, Nanosci & Nanotechnol Program, Kowloon, Hong Kong, Peoples R China
2.Hong Kong Univ Sci & Technol, Dept Phys, Kowloon, Hong Kong, Peoples R China
3.Hong Kong Univ Sci & Technol, KAUST HKUST Joint Micro Nanofluid Lab, Kowloon, Hong Kong, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China
推荐引用方式
GB/T 7714
Wang, Xiang,Li, Shunbo,Wang, Limu,et al. Microfluidic Device for Controllable Chemical Release via Field-Actuated Membrane Incorporating Nanoparticles[J]. JOURNAL OF NANOMATERIALS,2013,2013:864584.
APA Wang, Xiang.,Li, Shunbo.,Wang, Limu.,Yi, Xin.,Hui, Yu Sanna.,...&Weijia Wen.(2013).Microfluidic Device for Controllable Chemical Release via Field-Actuated Membrane Incorporating Nanoparticles.JOURNAL OF NANOMATERIALS,2013,864584.
MLA Wang, Xiang,et al."Microfluidic Device for Controllable Chemical Release via Field-Actuated Membrane Incorporating Nanoparticles".JOURNAL OF NANOMATERIALS 2013(2013):864584.
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