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学科主题物理化学
In Vivo Fast Equilibrium Microextraction by Stable and Biocompatible Nanofiber Membrane Sandwiched in Microfluidic Device
Wu, Qian1,2; Wu, Dapeng1; Guan, Yafeng1; Wu DP(吴大朋); Guan YF(关亚风)
刊名ANALYTICAL CHEMISTRY
2013-12-03
DOI10.1021/ac4028438
85期:23页:11524-11531
收录类别SCI
合作性质
文章类型Article
部门归属1
项目归属105
产权排名待补充
WOS标题词Science & Technology ; Physical Sciences
资助者1,1 ; 1,1 ; 1,1 ; 1,1
类目[WOS]Chemistry, Analytical
研究领域[WOS]Chemistry
关键词[WOS]SOLID-PHASE MICROEXTRACTION ; COLLAGEN NANOFIBERS ; PROTEIN-BINDING ; CORE-SHEATH ; RELEASE ; WETTABILITY ; SCAFFOLDS ; SENSORS ; SAMPLES
英文摘要In vivo analysis poses higher requirements about the biocompatibility, selectivity and speed of analytical method. In this study, an in vivo fast equilibrium micro-extraction method was developed with a biocompatible core sheath electrospun nanofiber membrane sandwiched within a microfluidic unit. The polystyrene/collagen core sheath nanofiber membrane was coaxially electrospun and strengthened with in situ glutaraldehyde cross-linking. This membrane not only kept high mass transfer rate, large extraction capacity and biomatrix resistance as our previously proposed membrane (Anal. Chem. 2013, 85 (12), 5924-5932), but also got much better mechanical strength and stability in water. The microfluidic device was designed to sandwich the membrane, and the blood in vivo can be introduced into it and get contact with the membrane repetitively. With this membrane and device, a 2-min equilibrium in vivo extraction method was established, validated in a simulated blood circulation system, and was used to monitor the pharmacokinetic profiles of desipramine in rabbits. The free and total concentration of desipramine in vivo was monitored with 10-min interval almost without rabbit blood consumed. The results met well with those of in vitro extraction, and a correlation factor of 0.99 was obtained.
语种英语
资助者1,1 ; 1,1 ; 1,1 ; 1,1
原文出处查看原文
WOS记录号WOS:000327999800050
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/119283
专题中国科学院大连化学物理研究所
通讯作者Wu DP(吴大朋); Guan YF(关亚风)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Dalian Inst Chem Phys, Beijing 100039, Peoples R China
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GB/T 7714
Wu, Qian,Wu, Dapeng,Guan, Yafeng,et al. In Vivo Fast Equilibrium Microextraction by Stable and Biocompatible Nanofiber Membrane Sandwiched in Microfluidic Device[J]. ANALYTICAL CHEMISTRY,2013,85(23):11524-11531.
APA Wu, Qian,Wu, Dapeng,Guan, Yafeng,吴大朋,&关亚风.(2013).In Vivo Fast Equilibrium Microextraction by Stable and Biocompatible Nanofiber Membrane Sandwiched in Microfluidic Device.ANALYTICAL CHEMISTRY,85(23),11524-11531.
MLA Wu, Qian,et al."In Vivo Fast Equilibrium Microextraction by Stable and Biocompatible Nanofiber Membrane Sandwiched in Microfluidic Device".ANALYTICAL CHEMISTRY 85.23(2013):11524-11531.
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