DICP OpenIR
Subject Area物理化学
In Vivo Fast Equilibrium Microextraction by Stable and Biocompatible Nanofiber Membrane Sandwiched in Microfluidic Device
Wu, Qian1,2; Wu, Dapeng1; Guan, Yafeng1; Wu DP(吴大朋); Guan YF(关亚风)
Source PublicationANALYTICAL CHEMISTRY
2013-12-03
DOI10.1021/ac4028438
Volume85Issue:23Pages:11524-11531
Indexed BySCI
Cooperation Status
SubtypeArticle
Department1
Funding Project105
Contribution Rank待补充
WOS HeadingsScience & Technology ; Physical Sciences
Funding Organization1,1 ; 1,1 ; 1,1 ; 1,1
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordSOLID-PHASE MICROEXTRACTION ; COLLAGEN NANOFIBERS ; PROTEIN-BINDING ; CORE-SHEATH ; RELEASE ; WETTABILITY ; SCAFFOLDS ; SENSORS ; SAMPLES
AbstractIn vivo analysis poses higher requirements about the biocompatibility, selectivity and speed of analytical method. In this study, an in vivo fast equilibrium micro-extraction method was developed with a biocompatible core sheath electrospun nanofiber membrane sandwiched within a microfluidic unit. The polystyrene/collagen core sheath nanofiber membrane was coaxially electrospun and strengthened with in situ glutaraldehyde cross-linking. This membrane not only kept high mass transfer rate, large extraction capacity and biomatrix resistance as our previously proposed membrane (Anal. Chem. 2013, 85 (12), 5924-5932), but also got much better mechanical strength and stability in water. The microfluidic device was designed to sandwich the membrane, and the blood in vivo can be introduced into it and get contact with the membrane repetitively. With this membrane and device, a 2-min equilibrium in vivo extraction method was established, validated in a simulated blood circulation system, and was used to monitor the pharmacokinetic profiles of desipramine in rabbits. The free and total concentration of desipramine in vivo was monitored with 10-min interval almost without rabbit blood consumed. The results met well with those of in vitro extraction, and a correlation factor of 0.99 was obtained.
Language英语
Funding Organization1,1 ; 1,1 ; 1,1 ; 1,1
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WOS IDWOS:000327999800050
Citation statistics
Cited Times:19[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/119283
Collection中国科学院大连化学物理研究所
Corresponding AuthorWu DP(吴大朋); Guan YF(关亚风)
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Dalian Inst Chem Phys, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Wu, Qian,Wu, Dapeng,Guan, Yafeng,et al. In Vivo Fast Equilibrium Microextraction by Stable and Biocompatible Nanofiber Membrane Sandwiched in Microfluidic Device[J]. ANALYTICAL CHEMISTRY,2013,85(23):11524-11531.
APA Wu, Qian,Wu, Dapeng,Guan, Yafeng,吴大朋,&关亚风.(2013).In Vivo Fast Equilibrium Microextraction by Stable and Biocompatible Nanofiber Membrane Sandwiched in Microfluidic Device.ANALYTICAL CHEMISTRY,85(23),11524-11531.
MLA Wu, Qian,et al."In Vivo Fast Equilibrium Microextraction by Stable and Biocompatible Nanofiber Membrane Sandwiched in Microfluidic Device".ANALYTICAL CHEMISTRY 85.23(2013):11524-11531.
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