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学科主题: 物理化学
题名: In Vivo Fast Equilibrium Microextraction by Stable and Biocompatible Nanofiber Membrane Sandwiched in Microfluidic Device
作者: Wu, Qian1, 2;  Wu, Dapeng1;  Guan, Yafeng1
通讯作者: 吴大朋 ;  关亚风
刊名: ANALYTICAL CHEMISTRY
发表日期: 2013-12-03
DOI: 10.1021/ac4028438
卷: 85, 期:23, 页:11524-11531
收录类别: SCI
合作性质: 
文章类型: Article
部门归属: 1
项目归属: 105
产权排名: 待补充
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
资助者: 1,1
研究领域[WOS]: Chemistry
英文摘要: In vivo analysis poses higher requirements about the biocompatibility, selectivity and speed of analytical method. In this study, an in vivo fast equilibrium micro-extraction method was developed with a biocompatible core sheath electrospun nanofiber membrane sandwiched within a microfluidic unit. The polystyrene/collagen core sheath nanofiber membrane was coaxially electrospun and strengthened with in situ glutaraldehyde cross-linking. This membrane not only kept high mass transfer rate, large extraction capacity and biomatrix resistance as our previously proposed membrane (Anal. Chem. 2013, 85 (12), 5924-5932), but also got much better mechanical strength and stability in water. The microfluidic device was designed to sandwich the membrane, and the blood in vivo can be introduced into it and get contact with the membrane repetitively. With this membrane and device, a 2-min equilibrium in vivo extraction method was established, validated in a simulated blood circulation system, and was used to monitor the pharmacokinetic profiles of desipramine in rabbits. The free and total concentration of desipramine in vivo was monitored with 10-min interval almost without rabbit blood consumed. The results met well with those of in vitro extraction, and a correlation factor of 0.99 was obtained.
关键词[WOS]: SOLID-PHASE MICROEXTRACTION ;  COLLAGEN NANOFIBERS ;  PROTEIN-BINDING ;  CORE-SHEATH ;  RELEASE ;  WETTABILITY ;  SCAFFOLDS ;  SENSORS ;  SAMPLES
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000327999800050
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/119283
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Grad Sch, Dalian Inst Chem Phys, Beijing 100039, Peoples R China

Recommended Citation:
Wu, Qian,Wu, Dapeng,Guan, Yafeng. In Vivo Fast Equilibrium Microextraction by Stable and Biocompatible Nanofiber Membrane Sandwiched in Microfluidic Device[J]. ANALYTICAL CHEMISTRY,2013,85(23):11524-11531.
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