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学科主题: 物理化学
题名: Improvement of mannitol production by Lactobacillus brevis mutant 3-A5 based on dual-stage pH control and fed-batch fermentations
作者: Yue, Min1, 2;  Cao, Hailong1;  Zhang, Jianping1, 2;  Li, Shuguang1;  Meng, Yanyu1, 2;  Chen, Wei1;  Huang, Lishuxin1, 2;  Du, Yuguang1
通讯作者: 杜昱光
关键词: Mannitol ;  Dual-stage pH control ;  Lactobacillus brevis ;  Batch fermentation ;  Fed-batch fermentation
刊名: WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
发表日期: 2013-10-01
DOI: 10.1007/s11274-013-1357-6
卷: 29, 期:10, 页:1923-1930
收录类别: SCI
合作性质: 
文章类型: Article
部门归属: 18
项目归属: 1805
产权排名: 待补充
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Biotechnology & Applied Microbiology
资助者: 1,1
研究领域[WOS]: Biotechnology & Applied Microbiology
英文摘要: Lactobacillus brevis 3-A5 was isolated and expected to produce mannitol efficiently by regulating pH in batch and fed-batch fermentations. In 48 h batch fermentations with free and constant pH, the optimal pH for cell growth and mannitol production in the first 24 h of incubation was 5.5, whereas that for mannitol production in the second 24 h of incubation was 4.5. To achieve high cell density and mannitol yield simultaneously, a dual-stage pH control strategy was proposed based on the kinetic analysis of mannitol production. The pH value was controlled at 5.5 for the first 12 h of fermentation and subsequently shifted to 4.5 until the fermentation was completed. Under dual-stage pH control fermentation, a 103 g/L yield of mannitol with a volumetric production rate of 3.7 g/L/h was achieved after 28 h. The dual-stage pH control fed-batch fermentation strategy was further developed to improve mannitol yield, wherein the yield increased by 109 % to 215 g/L after 98 h of fermentation. This value is the highest yield of mannitol ever reported using L. brevis.
关键词[WOS]: INTERMEDIUS NRRL B-3693 ;  LACTIC-ACID BACTERIA ;  REUTERI CRL 1101 ;  ORGANIC-ACIDS ;  GROWTH
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000325035100020
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/119287
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Nat Prod & Glycobiotechnol Res Grp, Liaoning Prov Key Lab Carbohydrates, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China

Recommended Citation:
Yue, Min,Cao, Hailong,Zhang, Jianping,et al. Improvement of mannitol production by Lactobacillus brevis mutant 3-A5 based on dual-stage pH control and fed-batch fermentations[J]. WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY,2013,29(10):1923-1930.
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