DICP OpenIR
Subject Area物理化学
Synthesis of isoprenoid chain-contained chemical probes for an investigation of molecular interactions by using quartz crystal microbalance
Liu, Wujun; Zhang, Yixin; Hou, Shuhua; Zhao, Zongbao Kent1; Zhao ZB(赵宗保)
KeywordIsoprenoid Chain Chemical Probe Molecular Interaction Quartz Crystal Microbalance Molecular Docking
Source PublicationTETRAHEDRON LETTERS
2013-11-13
DOI10.1016/j.tetlet.2013.09.004
Volume54Issue:46Pages:6208-6210
Indexed BySCI ; IC
Cooperation Status
SubtypeArticle
Department18
Funding Project1816
Contribution Rank待补充
WOS HeadingsScience & Technology ; Physical Sciences
Funding Organization1,1 ; 1,1 ; 1,1 ; 1,1
WOS SubjectChemistry, Organic
WOS Research AreaChemistry
WOS KeywordSELF-ASSEMBLED MONOLAYERS ; PHOTOAFFINITY PROBE ; ESCHERICHIA-COLI ; FATTY-ACIDS ; SURFACES ; ADSORPTION ; PATHWAY ; BIOSYNTHESIS ; PROTEINS ; BINDING
AbstractFive probes including four that contained isoprenoid chain were synthesized. These probes were assembled onto the gold-coated quartz crystal chips for analysis of their interactions with four yeast proteins by using the quartz crystal microbalance technology. Results showed that 3-phosphoglycerate phosphokinase and triosephosphate isomerase had clear interactions with certain probes, while glutathione reductase and phosphoglucose isomerase gave much lower interaction signals. It also suggested that 3-phosphoglycerate phosphokinase had two sites interacting with the probe attached with a geranyl moiety. Further molecule simulation experiments provided supportive information on these intermolecular interactions. Together, our data suggested that there are hydrophobic interactions, with relatively good selectivity, between isoprenoid chain and proteins. (C) 2013 Elsevier Ltd. All rights reserved.
Language英语
Funding Organization1,1 ; 1,1 ; 1,1 ; 1,1
URL查看原文
WOS IDWOS:000326009300014
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/119307
Collection中国科学院大连化学物理研究所
Corresponding AuthorZhao ZB(赵宗保)
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian Natl Lab Clean Energy, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Liu, Wujun,Zhang, Yixin,Hou, Shuhua,et al. Synthesis of isoprenoid chain-contained chemical probes for an investigation of molecular interactions by using quartz crystal microbalance[J]. TETRAHEDRON LETTERS,2013,54(46):6208-6210.
APA Liu, Wujun,Zhang, Yixin,Hou, Shuhua,Zhao, Zongbao Kent,&赵宗保.(2013).Synthesis of isoprenoid chain-contained chemical probes for an investigation of molecular interactions by using quartz crystal microbalance.TETRAHEDRON LETTERS,54(46),6208-6210.
MLA Liu, Wujun,et al."Synthesis of isoprenoid chain-contained chemical probes for an investigation of molecular interactions by using quartz crystal microbalance".TETRAHEDRON LETTERS 54.46(2013):6208-6210.
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