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学科主题物理化学
Synthesis of isoprenoid chain-contained chemical probes for an investigation of molecular interactions by using quartz crystal microbalance
Liu, Wujun; Zhang, Yixin; Hou, Shuhua; Zhao, Zongbao Kent1; Zhao ZB(赵宗保)
关键词Isoprenoid Chain Chemical Probe Molecular Interaction Quartz Crystal Microbalance Molecular Docking
刊名TETRAHEDRON LETTERS
2013-11-13
DOI10.1016/j.tetlet.2013.09.004
54期:46页:6208-6210
收录类别SCI ; IC
合作性质
文章类型Article
部门归属18
项目归属1816
产权排名待补充
WOS标题词Science & Technology ; Physical Sciences
资助者1,1 ; 1,1 ; 1,1 ; 1,1
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]SELF-ASSEMBLED MONOLAYERS ; PHOTOAFFINITY PROBE ; ESCHERICHIA-COLI ; FATTY-ACIDS ; SURFACES ; ADSORPTION ; PATHWAY ; BIOSYNTHESIS ; PROTEINS ; BINDING
英文摘要Five probes including four that contained isoprenoid chain were synthesized. These probes were assembled onto the gold-coated quartz crystal chips for analysis of their interactions with four yeast proteins by using the quartz crystal microbalance technology. Results showed that 3-phosphoglycerate phosphokinase and triosephosphate isomerase had clear interactions with certain probes, while glutathione reductase and phosphoglucose isomerase gave much lower interaction signals. It also suggested that 3-phosphoglycerate phosphokinase had two sites interacting with the probe attached with a geranyl moiety. Further molecule simulation experiments provided supportive information on these intermolecular interactions. Together, our data suggested that there are hydrophobic interactions, with relatively good selectivity, between isoprenoid chain and proteins. (C) 2013 Elsevier Ltd. All rights reserved.
语种英语
资助者1,1 ; 1,1 ; 1,1 ; 1,1
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WOS记录号WOS:000326009300014
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/119307
专题中国科学院大连化学物理研究所
通讯作者Zhao ZB(赵宗保)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian Natl Lab Clean Energy, Dalian 116023, Peoples R China
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Liu, Wujun,Zhang, Yixin,Hou, Shuhua,et al. Synthesis of isoprenoid chain-contained chemical probes for an investigation of molecular interactions by using quartz crystal microbalance[J]. TETRAHEDRON LETTERS,2013,54(46):6208-6210.
APA Liu, Wujun,Zhang, Yixin,Hou, Shuhua,Zhao, Zongbao Kent,&赵宗保.(2013).Synthesis of isoprenoid chain-contained chemical probes for an investigation of molecular interactions by using quartz crystal microbalance.TETRAHEDRON LETTERS,54(46),6208-6210.
MLA Liu, Wujun,et al."Synthesis of isoprenoid chain-contained chemical probes for an investigation of molecular interactions by using quartz crystal microbalance".TETRAHEDRON LETTERS 54.46(2013):6208-6210.
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