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学科主题: 物理化学
题名: Synthesis of isoprenoid chain-contained chemical probes for an investigation of molecular interactions by using quartz crystal microbalance
作者: Liu, Wujun;  Zhang, Yixin;  Hou, Shuhua;  Zhao, Zongbao Kent1
通讯作者: 赵宗保
关键词: Isoprenoid chain ;  Chemical probe ;  Molecular interaction ;  Quartz crystal microbalance ;  Molecular docking
刊名: TETRAHEDRON LETTERS
发表日期: 2013-11-13
DOI: 10.1016/j.tetlet.2013.09.004
卷: 54, 期:46, 页:6208-6210
收录类别: SCI ;  IC
合作性质: 
文章类型: Article
部门归属: 18
项目归属: 1816
产权排名: 待补充
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Organic
资助者: 1,1
研究领域[WOS]: Chemistry
英文摘要: Five probes including four that contained isoprenoid chain were synthesized. These probes were assembled onto the gold-coated quartz crystal chips for analysis of their interactions with four yeast proteins by using the quartz crystal microbalance technology. Results showed that 3-phosphoglycerate phosphokinase and triosephosphate isomerase had clear interactions with certain probes, while glutathione reductase and phosphoglucose isomerase gave much lower interaction signals. It also suggested that 3-phosphoglycerate phosphokinase had two sites interacting with the probe attached with a geranyl moiety. Further molecule simulation experiments provided supportive information on these intermolecular interactions. Together, our data suggested that there are hydrophobic interactions, with relatively good selectivity, between isoprenoid chain and proteins. (C) 2013 Elsevier Ltd. All rights reserved.
关键词[WOS]: SELF-ASSEMBLED MONOLAYERS ;  PHOTOAFFINITY PROBE ;  ESCHERICHIA-COLI ;  FATTY-ACIDS ;  SURFACES ;  ADSORPTION ;  PATHWAY ;  BIOSYNTHESIS ;  PROTEINS ;  BINDING
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000326009300014
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/119307
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian Natl Lab Clean Energy, Dalian 116023, Peoples R China

Recommended Citation:
Liu, Wujun,Zhang, Yixin,Hou, Shuhua,et al. Synthesis of isoprenoid chain-contained chemical probes for an investigation of molecular interactions by using quartz crystal microbalance[J]. TETRAHEDRON LETTERS,2013,54(46):6208-6210.
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