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学科主题: 物理化学
题名: Synthesis of molecularly imprinted polymer sorbents and application for the determination of aminoglycosides antibiotics in honey
作者: Ji, Shunli1;  Zhang, Feifang1;  Luo, Xi1;  Yang, Bingcheng1;  Jin, Gaowa2;  Yan, Jingyu2;  Liang, Xinmiao1, 2
通讯作者: 杨丙成
关键词: Molecularly imprinted polymer ;  HILIC-MS/MS ;  Aminoglycoside antibiotics ;  Solid phase extraction ;  Honey samples
刊名: JOURNAL OF CHROMATOGRAPHY A
发表日期: 2013-10-25
DOI: 10.1016/j.chroma.2013.08.072
卷: 1313, 页:113-118
收录类别: SCI
合作性质: 
文章类型: Article
部门归属: 18
项目归属: 1803
产权排名: 待补充
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Analytical
资助者: 2,5
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry
英文摘要: Aminoglycoside antibiotic (AA)-selective molecularly imprinted polymer (MIP) sorbent was synthesized by polymerization of methacrylic acid and ethylene glycol dimethacrylate in the presence of streptomycin as template molecule. The MIP sorbent was in detail characterized and its performance was evaluated by selecting four model AAs including streptomycin, gentamicin, spectinomycin and dihydrostreptomycin. Relative to non-imprinted polymer (NIP), the MIPs exhibited much higher recognizable capacity and specificity to the AAs and negligible adsorption for non-AAs as well. In combination of hydrophilic interaction liquid chromatography-tandem mass spectrometry (HILIC-MS/MS), the MIP sorbent-based solid phase extraction (SPE) was able to effectively determine the residue of four model AAs in honey samples with recovery ranging from 90% to 110%. The limit of detection (and the limit of quantitation) of streptomycin, gentamicin, spectinomycin and dihydrostreptomycin was 4.5 (15.0), 2.4 (8.0), 6.0 (20.0) and 1.8 (6.0) mu g/kg, respectively. Relative standard deviations of intraday and inter-day assay under three spiked levels were 4.4-12.0% and 6.8-14.6%, respectively. (c) 2013 Elsevier B.V. All rights reserved.
关键词[WOS]: SOLID-PHASE MICROEXTRACTION ;  CHROMATOGRAPHY/TANDEM MASS-SPECTROMETRY ;  LIQUID-CHROMATOGRAPHY ;  HYDROPHILIC INTERACTION ;  EXTRACTION ;  SAMPLES ;  FLUOROQUINOLONES ;  STREPTOMYCIN ;  RECOGNITION ;  SEPARATION
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000325673200010
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/119343
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

Recommended Citation:
Ji, Shunli,Zhang, Feifang,Luo, Xi,et al. Synthesis of molecularly imprinted polymer sorbents and application for the determination of aminoglycosides antibiotics in honey[J]. JOURNAL OF CHROMATOGRAPHY A,2013,1313:113-118.
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