DICP OpenIR
Subject Area物理化学
Influences of levofloxacin salts on the metabolism of Escherichia coli by microcalorimetry
Wang, Cai-yun1; Xu, Fen1; Sun, Li-xian2; Sun, Yu-Jia3; Qiu, Shu-jun4; Zhao, Zhong-bao2; Tan, Hai-dong2; Wang, Shuang2; Sun LX(孙立贤)
KeywordMicrocalorimetry E. Coli Levofloxacin Lactate Levofloxacin Hydrochloride
Source PublicationJOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
2013
DOI10.1007/s10973-012-2426-z
Volume111Issue:1Pages:959-963
Indexed BySCI
Cooperation Status
SubtypeArticle
DepartmentDNL19,18
Funding ProjectDNL1903,1816
Contribution Rank待补充
WOS HeadingsScience & Technology ; Physical Sciences
Funding Organization2,3 ; 2,3 ; 2,3 ; 2,3
WOS SubjectChemistry, Analytical ; Chemistry, Physical
WOS Research AreaChemistry
WOS KeywordISOTHERMAL MICROCALORIMETRY ; ANTIBACTERIAL ACTIVITY ; GROWTH ; ANTIBIOTICS ; DH5-ALPHA
AbstractA microcalorimetric technique was used to evaluate the influence of both Levofloxacin lactate in sodium chloride injection (drug A) and Levofloxacin hydrochloride in sodium chloride injection (drug B) on the metabolism of Escherichia coli. By means of an isothermal calorimeter and ampoule method at 37 A degrees C, the power-time curves of E. coli growth were obtained under different conditions. The parameters such as the growth rate constant k, maximum power output P (m), time t (m) corresponding to the maximum power output and inhibitory ratio I of these two drugs were obtained. The results reveal that the inhibitory abilities enhance with increasing concentrations of the two drugs. The critical growth concentration and the half-inhibitory concentration IC50 were 0.15 and 0.079 mu g mL(-1) (for drug A), 0.13 and 0.061 mu g mL(-1) (for drug B), respectively. These results show the drug A has slightly better inhibitory effect on E. coli than that of drug B.
Language英语
Funding Organization2,3 ; 2,3 ; 2,3 ; 2,3
URL查看原文
WOS IDWOS:000313207400123
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/119377
Collection中国科学院大连化学物理研究所
Corresponding AuthorSun LX(孙立贤)
Affiliation1.Liaoning Normal Univ, Coll Chem & Chem Engn, Dalian 116029, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Mat & Thermochem Lab, Dalian 116023, Peoples R China
3.Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China
4.Guilin Univ Elect Technol, Sch Mat Sci & Engn, Guilin 541004, Peoples R China
Recommended Citation
GB/T 7714
Wang, Cai-yun,Xu, Fen,Sun, Li-xian,et al. Influences of levofloxacin salts on the metabolism of Escherichia coli by microcalorimetry[J]. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY,2013,111(1):959-963.
APA Wang, Cai-yun.,Xu, Fen.,Sun, Li-xian.,Sun, Yu-Jia.,Qiu, Shu-jun.,...&孙立贤.(2013).Influences of levofloxacin salts on the metabolism of Escherichia coli by microcalorimetry.JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY,111(1),959-963.
MLA Wang, Cai-yun,et al."Influences of levofloxacin salts on the metabolism of Escherichia coli by microcalorimetry".JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY 111.1(2013):959-963.
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