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学科主题物理化学
Influences of levofloxacin salts on the metabolism of Escherichia coli by microcalorimetry
Wang, Cai-yun1; Xu, Fen1; Sun, Li-xian2; Sun, Yu-Jia3; Qiu, Shu-jun4; Zhao, Zhong-bao2; Tan, Hai-dong2; Wang, Shuang2; Sun LX(孙立贤)
关键词Microcalorimetry E. Coli Levofloxacin Lactate Levofloxacin Hydrochloride
刊名JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
2013
DOI10.1007/s10973-012-2426-z
111期:1页:959-963
收录类别SCI
合作性质
文章类型Article
部门归属DNL19,18
项目归属DNL1903,1816
产权排名待补充
WOS标题词Science & Technology ; Physical Sciences
资助者2,3 ; 2,3 ; 2,3 ; 2,3
类目[WOS]Chemistry, Analytical ; Chemistry, Physical
研究领域[WOS]Chemistry
关键词[WOS]ISOTHERMAL MICROCALORIMETRY ; ANTIBACTERIAL ACTIVITY ; GROWTH ; ANTIBIOTICS ; DH5-ALPHA
英文摘要A microcalorimetric technique was used to evaluate the influence of both Levofloxacin lactate in sodium chloride injection (drug A) and Levofloxacin hydrochloride in sodium chloride injection (drug B) on the metabolism of Escherichia coli. By means of an isothermal calorimeter and ampoule method at 37 A degrees C, the power-time curves of E. coli growth were obtained under different conditions. The parameters such as the growth rate constant k, maximum power output P (m), time t (m) corresponding to the maximum power output and inhibitory ratio I of these two drugs were obtained. The results reveal that the inhibitory abilities enhance with increasing concentrations of the two drugs. The critical growth concentration and the half-inhibitory concentration IC50 were 0.15 and 0.079 mu g mL(-1) (for drug A), 0.13 and 0.061 mu g mL(-1) (for drug B), respectively. These results show the drug A has slightly better inhibitory effect on E. coli than that of drug B.
语种英语
资助者2,3 ; 2,3 ; 2,3 ; 2,3
原文出处查看原文
WOS记录号WOS:000313207400123
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/119377
专题中国科学院大连化学物理研究所
通讯作者Sun LX(孙立贤)
作者单位1.Liaoning Normal Univ, Coll Chem & Chem Engn, Dalian 116029, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Mat & Thermochem Lab, Dalian 116023, Peoples R China
3.Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China
4.Guilin Univ Elect Technol, Sch Mat Sci & Engn, Guilin 541004, Peoples R China
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GB/T 7714
Wang, Cai-yun,Xu, Fen,Sun, Li-xian,et al. Influences of levofloxacin salts on the metabolism of Escherichia coli by microcalorimetry[J]. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY,2013,111(1):959-963.
APA Wang, Cai-yun.,Xu, Fen.,Sun, Li-xian.,Sun, Yu-Jia.,Qiu, Shu-jun.,...&孙立贤.(2013).Influences of levofloxacin salts on the metabolism of Escherichia coli by microcalorimetry.JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY,111(1),959-963.
MLA Wang, Cai-yun,et al."Influences of levofloxacin salts on the metabolism of Escherichia coli by microcalorimetry".JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY 111.1(2013):959-963.
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