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学科主题: 物理化学
题名: Influences of levofloxacin salts on the metabolism of Escherichia coli by microcalorimetry
作者: Wang, Cai-yun1;  Xu, Fen1;  Sun, Li-xian2;  Sun, Yu-Jia3;  Qiu, Shu-jun4;  Zhao, Zhong-bao2;  Tan, Hai-dong2;  Wang, Shuang2
通讯作者: 孙立贤
关键词: Microcalorimetry ;  E. coli ;  Levofloxacin lactate ;  Levofloxacin hydrochloride
刊名: JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
发表日期: 2013
DOI: 10.1007/s10973-012-2426-z
卷: 111, 期:1, 页:959-963
收录类别: SCI
合作性质: 
文章类型: Article
部门归属: DNL19,18
项目归属: DNL1903,1816
产权排名: 待补充
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical ;  Chemistry, Physical
资助者: 2,3
研究领域[WOS]: Chemistry
英文摘要: A microcalorimetric technique was used to evaluate the influence of both Levofloxacin lactate in sodium chloride injection (drug A) and Levofloxacin hydrochloride in sodium chloride injection (drug B) on the metabolism of Escherichia coli. By means of an isothermal calorimeter and ampoule method at 37 A degrees C, the power-time curves of E. coli growth were obtained under different conditions. The parameters such as the growth rate constant k, maximum power output P (m), time t (m) corresponding to the maximum power output and inhibitory ratio I of these two drugs were obtained. The results reveal that the inhibitory abilities enhance with increasing concentrations of the two drugs. The critical growth concentration and the half-inhibitory concentration IC50 were 0.15 and 0.079 mu g mL(-1) (for drug A), 0.13 and 0.061 mu g mL(-1) (for drug B), respectively. These results show the drug A has slightly better inhibitory effect on E. coli than that of drug B.
关键词[WOS]: ISOTHERMAL MICROCALORIMETRY ;  ANTIBACTERIAL ACTIVITY ;  GROWTH ;  ANTIBIOTICS ;  DH5-ALPHA
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000313207400123
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/119377
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Liaoning Normal Univ, Coll Chem & Chem Engn, Dalian 116029, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Mat & Thermochem Lab, Dalian 116023, Peoples R China
3.Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China
4.Guilin Univ Elect Technol, Sch Mat Sci & Engn, Guilin 541004, Peoples R China

Recommended Citation:
Wang, Cai-yun,Xu, Fen,Sun, Li-xian,et al. Influences of levofloxacin salts on the metabolism of Escherichia coli by microcalorimetry[J]. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY,2013,111(1):959-963.
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