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学科主题: 物理化学
题名: FTO-mediated formation of N-6-hydroxymethyladenosine and N-6-formyladenosine in mammalian RNA
作者: Fu, Ye1, 2;  Jia, Guifang1, 2;  Pang, Xueqin3, 4, 5, 6;  Wang, Richard N.1, 2;  Wang, Xiao1, 2;  Li, Charles J.1, 2;  Smemo, Scott7;  Dai, Qing1, 2;  Bailey, Kathleen A.7;  Nobrega, Marcelo A.7;  Han, Ke-Li5, 6;  Cui, Qiang3, 4;  He, Chuan1, 2
通讯作者: Ye Fu
刊名: NATURE COMMUNICATIONS
发表日期: 2013-04-01
DOI: 10.1038/ncomms2822
卷: 4, 页:1798
收录类别: SCI
合作性质: 
文章类型: Article
部门归属: 11
项目归属: 1101
产权排名: 待补充
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
资助者: 3,3
研究领域[WOS]: Science & Technology - Other Topics
英文摘要: N-6-methyladenosine is a prevalent internal modification in messenger RNA and non-coding RNA affecting various cellular pathways. Here we report the discovery of two additional modifications, N-6-hydroxymethyladenosine (hm(6)A) and N-6-formyladenosine (f(6)A), in mammalian messenger RNA. We show that Fe-II-and alpha-ketoglutarate-dependent fat mass and obesity-associated (FTO) protein oxidize N-6-methyladenosine to generate N-6-hydroxymethyladenosine as an intermediate modification, and N-6-formyladenosine as a further oxidized product. N-6-hydroxymethyladenosine and N-6-formyladenosine have half-life times of similar to 3 h in aqueous solution under physiological relevant conditions, and are present in isolated messenger RNA from human cells as well as mouse tissues. These previously unknown modifications derived from the prevalent N-6-methyladenosine in messenger RNA, formed through oxidative RNA demethylation, may dynamically modulate RNA-protein interactions to affect gene expression regulation.
关键词[WOS]: OBESITY-ASSOCIATED FTO ;  MESSENGER-RNA ;  ESCHERICHIA-COLI ;  OXIDATIVE DEMETHYLATION ;  ADULT OBESITY ;  DNA ;  GENE ;  ALKB ;  5-HYDROXYMETHYLCYTOSINE ;  5-CARBOXYLCYTOSINE
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000318872100155
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/119390
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Univ Chicago, Dept Chem, Chicago, IL 60637 USA
2.Univ Chicago, Inst Biophys Dynam, Chicago, IL 60637 USA
3.Univ Wisconsin, Dept Chem, Madison, WI 53706 USA
4.Univ Wisconsin, Inst Theoret Chem, Madison, WI 53706 USA
5.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Mol React Dynam, Dalian 116023, Liaoning, Peoples R China
6.Chinese Acad Sci, Dalian Inst Chem Phys, Ctr Theoret & Computat Chem, Dalian 116023, Liaoning, Peoples R China
7.Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA

Recommended Citation:
Fu, Ye,Jia, Guifang,Pang, Xueqin,et al. FTO-mediated formation of N-6-hydroxymethyladenosine and N-6-formyladenosine in mammalian RNA[J]. NATURE COMMUNICATIONS,2013,4:1798.
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