DICP OpenIR
学科主题物理化学
FTO-mediated formation of N-6-hydroxymethyladenosine and N-6-formyladenosine in mammalian RNA
Fu, Ye1,2; Jia, Guifang1,2; Pang, Xueqin3,4,5,6; Wang, Richard N.1,2; Wang, Xiao1,2; Li, Charles J.1,2; Smemo, Scott7; Dai, Qing1,2; Bailey, Kathleen A.7; Nobrega, Marcelo A.7; Han, Ke-Li5,6; Cui, Qiang3,4; He, Chuan1,2; Ye Fu
刊名NATURE COMMUNICATIONS
2013-04-01
DOI10.1038/ncomms2822
4页:1798
收录类别SCI
合作性质
文章类型Article
部门归属11
项目归属1101
产权排名待补充
WOS标题词Science & Technology
资助者3,3 ; 3,3 ; 3,3 ; 3,3
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]OBESITY-ASSOCIATED FTO ; MESSENGER-RNA ; ESCHERICHIA-COLI ; OXIDATIVE DEMETHYLATION ; ADULT OBESITY ; DNA ; GENE ; ALKB ; 5-HYDROXYMETHYLCYTOSINE ; 5-CARBOXYLCYTOSINE
英文摘要N-6-methyladenosine is a prevalent internal modification in messenger RNA and non-coding RNA affecting various cellular pathways. Here we report the discovery of two additional modifications, N-6-hydroxymethyladenosine (hm(6)A) and N-6-formyladenosine (f(6)A), in mammalian messenger RNA. We show that Fe-II-and alpha-ketoglutarate-dependent fat mass and obesity-associated (FTO) protein oxidize N-6-methyladenosine to generate N-6-hydroxymethyladenosine as an intermediate modification, and N-6-formyladenosine as a further oxidized product. N-6-hydroxymethyladenosine and N-6-formyladenosine have half-life times of similar to 3 h in aqueous solution under physiological relevant conditions, and are present in isolated messenger RNA from human cells as well as mouse tissues. These previously unknown modifications derived from the prevalent N-6-methyladenosine in messenger RNA, formed through oxidative RNA demethylation, may dynamically modulate RNA-protein interactions to affect gene expression regulation.
语种英语
资助者3,3 ; 3,3 ; 3,3 ; 3,3
原文出处查看原文
WOS记录号WOS:000318872100155
引用统计
被引频次:93[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/119390
专题中国科学院大连化学物理研究所
通讯作者Ye Fu
作者单位1.Univ Chicago, Dept Chem, Chicago, IL 60637 USA
2.Univ Chicago, Inst Biophys Dynam, Chicago, IL 60637 USA
3.Univ Wisconsin, Dept Chem, Madison, WI 53706 USA
4.Univ Wisconsin, Inst Theoret Chem, Madison, WI 53706 USA
5.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Mol React Dynam, Dalian 116023, Liaoning, Peoples R China
6.Chinese Acad Sci, Dalian Inst Chem Phys, Ctr Theoret & Computat Chem, Dalian 116023, Liaoning, Peoples R China
7.Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA
推荐引用方式
GB/T 7714
Fu, Ye,Jia, Guifang,Pang, Xueqin,et al. FTO-mediated formation of N-6-hydroxymethyladenosine and N-6-formyladenosine in mammalian RNA[J]. NATURE COMMUNICATIONS,2013,4:1798.
APA Fu, Ye.,Jia, Guifang.,Pang, Xueqin.,Wang, Richard N..,Wang, Xiao.,...&Ye Fu.(2013).FTO-mediated formation of N-6-hydroxymethyladenosine and N-6-formyladenosine in mammalian RNA.NATURE COMMUNICATIONS,4,1798.
MLA Fu, Ye,et al."FTO-mediated formation of N-6-hydroxymethyladenosine and N-6-formyladenosine in mammalian RNA".NATURE COMMUNICATIONS 4(2013):1798.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
2013lj0LCO2VQX.PDF(1099KB) 开放获取CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Fu, Ye]的文章
[Jia, Guifang]的文章
[Pang, Xueqin]的文章
百度学术
百度学术中相似的文章
[Fu, Ye]的文章
[Jia, Guifang]的文章
[Pang, Xueqin]的文章
必应学术
必应学术中相似的文章
[Fu, Ye]的文章
[Jia, Guifang]的文章
[Pang, Xueqin]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。