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学科主题物理化学
Reversible Near-Infrared Fluorescent Probe Introducing Tellurium to Mimetic Glutathione Peroxidase for Monitoring the Redox Cycles between Peroxynitrite and Glutathione in Vivo
Yu, Fabiao; Li, Peng; Wang, Bingshuai; Han, Keli; Han KL(韩克利)
刊名JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
2013-05-22
DOI10.1021/ja401360a
135期:20页:7674-7680
收录类别SCI ; IC
合作性质
文章类型Article
部门归属11
项目归属1101
产权排名待补充
WOS标题词Science & Technology ; Physical Sciences
资助者1,1 ; 1,1 ; 1,1 ; 1,1
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]THIOLS REDUCING REPAIR ; H2O2 OXIDATIVE STRESS ; LIVING CELLS ; NITRIC-OXIDE ; REACTIVE OXYGEN ; TYROSINE NITRATION ; BIOLOGICAL-SYSTEMS ; SUPEROXIDE ; BODIPY ; MITOCHONDRIA
英文摘要The redox homeostasis between peroxynitrite and glutathione is closely associated with the physiological and pathological processes, e.g. vascular tissue prolonged relaxation and smooth muscle preparations, attenuation hepatic necrosis, and activation matrix metalloproteinase-2. We report a near-infrared fluorescent probe based on heptamethine cyanine, which integrates with telluroenzyme mimics for monitoring the changes of ONOO-/GSH levels in cells and in vivo. The probe can reversibly respond to ONOO- and GSH and exhibits high selectivity, sensitivity, and mitochondrial target. It is successfully applied to visualize the changes of redox cycles during the outbreak of ONOO- and the antioxidant GSH repair in cells and animal. The probe would provide a significant advance on the redox events involved in the cellular redox regulation.
语种英语
资助者1,1 ; 1,1 ; 1,1 ; 1,1
原文出处查看原文
WOS记录号WOS:000319551000041
引用统计
被引频次:275[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/119406
专题中国科学院大连化学物理研究所
通讯作者Han KL(韩克利)
作者单位Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Moleclar React Dynam, Dalian 116023, Peoples R China
推荐引用方式
GB/T 7714
Yu, Fabiao,Li, Peng,Wang, Bingshuai,et al. Reversible Near-Infrared Fluorescent Probe Introducing Tellurium to Mimetic Glutathione Peroxidase for Monitoring the Redox Cycles between Peroxynitrite and Glutathione in Vivo[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2013,135(20):7674-7680.
APA Yu, Fabiao,Li, Peng,Wang, Bingshuai,Han, Keli,&韩克利.(2013).Reversible Near-Infrared Fluorescent Probe Introducing Tellurium to Mimetic Glutathione Peroxidase for Monitoring the Redox Cycles between Peroxynitrite and Glutathione in Vivo.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,135(20),7674-7680.
MLA Yu, Fabiao,et al."Reversible Near-Infrared Fluorescent Probe Introducing Tellurium to Mimetic Glutathione Peroxidase for Monitoring the Redox Cycles between Peroxynitrite and Glutathione in Vivo".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 135.20(2013):7674-7680.
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