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学科主题: 物理化学
题名: Reversible Near-Infrared Fluorescent Probe Introducing Tellurium to Mimetic Glutathione Peroxidase for Monitoring the Redox Cycles between Peroxynitrite and Glutathione in Vivo
作者: Yu, Fabiao1;  Li, Peng1;  Wang, Bingshuai1;  Han, Keli1
通讯作者: 韩克利
刊名: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
发表日期: 2013-05-22
DOI: 10.1021/ja401360a
卷: 135, 期:20, 页:7674-7680
收录类别: SCI ;  IC
合作性质: 
文章类型: Article
部门归属: 11
项目归属: 1101
产权排名: 待补充
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
资助者: 1,1
研究领域[WOS]: Chemistry
英文摘要: The redox homeostasis between peroxynitrite and glutathione is closely associated with the physiological and pathological processes, e.g. vascular tissue prolonged relaxation and smooth muscle preparations, attenuation hepatic necrosis, and activation matrix metalloproteinase-2. We report a near-infrared fluorescent probe based on heptamethine cyanine, which integrates with telluroenzyme mimics for monitoring the changes of ONOO-/GSH levels in cells and in vivo. The probe can reversibly respond to ONOO- and GSH and exhibits high selectivity, sensitivity, and mitochondrial target. It is successfully applied to visualize the changes of redox cycles during the outbreak of ONOO- and the antioxidant GSH repair in cells and animal. The probe would provide a significant advance on the redox events involved in the cellular redox regulation.
关键词[WOS]: THIOLS REDUCING REPAIR ;  H2O2 OXIDATIVE STRESS ;  LIVING CELLS ;  NITRIC-OXIDE ;  REACTIVE OXYGEN ;  TYROSINE NITRATION ;  BIOLOGICAL-SYSTEMS ;  SUPEROXIDE ;  BODIPY ;  MITOCHONDRIA
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000319551000041
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/119406
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Moleclar React Dynam, Dalian 116023, Peoples R China

Recommended Citation:
Yu, Fabiao,Li, Peng,Wang, Bingshuai,et al. Reversible Near-Infrared Fluorescent Probe Introducing Tellurium to Mimetic Glutathione Peroxidase for Monitoring the Redox Cycles between Peroxynitrite and Glutathione in Vivo[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2013,135(20):7674-7680.
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