DICP OpenIR
Subject Area物理化学
Reversible Near-Infrared Fluorescent Probe Introducing Tellurium to Mimetic Glutathione Peroxidase for Monitoring the Redox Cycles between Peroxynitrite and Glutathione in Vivo
Yu, Fabiao; Li, Peng; Wang, Bingshuai; Han, Keli; Han KL(韩克利)
Source PublicationJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
2013-05-22
DOI10.1021/ja401360a
Volume135Issue:20Pages:7674-7680
Indexed BySCI ; IC
Cooperation Status
SubtypeArticle
Department11
Funding Project1101
Contribution Rank待补充
WOS HeadingsScience & Technology ; Physical Sciences
Funding Organization1,1 ; 1,1 ; 1,1 ; 1,1
WOS SubjectChemistry, Multidisciplinary
WOS Research AreaChemistry
WOS KeywordTHIOLS REDUCING REPAIR ; H2O2 OXIDATIVE STRESS ; LIVING CELLS ; NITRIC-OXIDE ; REACTIVE OXYGEN ; TYROSINE NITRATION ; BIOLOGICAL-SYSTEMS ; SUPEROXIDE ; BODIPY ; MITOCHONDRIA
AbstractThe redox homeostasis between peroxynitrite and glutathione is closely associated with the physiological and pathological processes, e.g. vascular tissue prolonged relaxation and smooth muscle preparations, attenuation hepatic necrosis, and activation matrix metalloproteinase-2. We report a near-infrared fluorescent probe based on heptamethine cyanine, which integrates with telluroenzyme mimics for monitoring the changes of ONOO-/GSH levels in cells and in vivo. The probe can reversibly respond to ONOO- and GSH and exhibits high selectivity, sensitivity, and mitochondrial target. It is successfully applied to visualize the changes of redox cycles during the outbreak of ONOO- and the antioxidant GSH repair in cells and animal. The probe would provide a significant advance on the redox events involved in the cellular redox regulation.
Language英语
Funding Organization1,1 ; 1,1 ; 1,1 ; 1,1
URL查看原文
WOS IDWOS:000319551000041
Citation statistics
Cited Times:336[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/119406
Collection中国科学院大连化学物理研究所
Corresponding AuthorHan KL(韩克利)
AffiliationChinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Moleclar React Dynam, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Yu, Fabiao,Li, Peng,Wang, Bingshuai,et al. Reversible Near-Infrared Fluorescent Probe Introducing Tellurium to Mimetic Glutathione Peroxidase for Monitoring the Redox Cycles between Peroxynitrite and Glutathione in Vivo[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2013,135(20):7674-7680.
APA Yu, Fabiao,Li, Peng,Wang, Bingshuai,Han, Keli,&韩克利.(2013).Reversible Near-Infrared Fluorescent Probe Introducing Tellurium to Mimetic Glutathione Peroxidase for Monitoring the Redox Cycles between Peroxynitrite and Glutathione in Vivo.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,135(20),7674-7680.
MLA Yu, Fabiao,et al."Reversible Near-Infrared Fluorescent Probe Introducing Tellurium to Mimetic Glutathione Peroxidase for Monitoring the Redox Cycles between Peroxynitrite and Glutathione in Vivo".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 135.20(2013):7674-7680.
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