DICP OpenIR
Subject Area物理化学
Oligomers matrix-assisted dispersion of high content of carbon nanotubes into monolithic column for online separation and enrichment of proteins from complex biological samples
Zhou, Chanyuan1; Du, Zhuo1; Li, Gongke1; Zhang, Yukui2; Cai, Zongwei3; Zhuo Du; Li GK(李攻科)
Source PublicationANALYST
2013
DOI10.1039/c3an00951c
Volume138Issue:19Pages:5783-5790
Indexed BySCI
Cooperation Status
SubtypeArticle
Department18
Funding Project1810
Contribution Rank待补充
WOS HeadingsScience & Technology ; Physical Sciences
Funding Organization2,4 ; 2,4 ; 2,4 ; 2,4
WOS SubjectChemistry, Analytical
WOS Research AreaChemistry
WOS KeywordSOLID-PHASE EXTRACTION ; CAPILLARY ELECTROCHROMATOGRAPHY ; SMALL MOLECULES ; BASIC-PROTEINS ; WATER SAMPLES ; POLYMER ; CHROMATOGRAPHY
AbstractIn this work, a new oligomer matrix-assisted dispersion (OMAD) method for the preparation of homogeneous dispersion of multi-walled carbon nanotubes (MWNTs) incorporated monolithic column was developed. Oligomers matrix as a scaffold could allow MWNTs to entangle with it instead of self-aggregation, so the MWNTs remain in the polymer network followed by in situ self-solidification. The OMAD method not only greatly enlarged the BET surface area of MWNTs incorporated monolithic column from 13.8 m(2) g(-1) to 85.5 m(2) g(-1) without a significant effect on the surface chemistry of the MWNTs, but also improved the dispersion of MWNTs making its content up to 5 wt% (with respect to monomers). The synthesized materials combine the favorable attributes of both high permeability and large surface area, making them excellent candidates for on-line separation and enrichment of proteins. The oligomer matrix-assisted dispersion MWNTs incorporated monolithic columns (OMAD-MMC) exhibited higher enrichment factors and the adsorption capacity is about 5-fold for basic proteins compared with MWNTs incorporated monolithic columns (MMC) prepared by the conventional in situ polymerization. The practical application of OMAD-MMC was proven by selective extraction of hemoglobin in human whole blood samples with SDS-PAGE. On the basis of the results, OMAD as a simple and effective method for dispersion high content MWNTs into monolithic columns shows great promise.
Language英语
Funding Organization2,4 ; 2,4 ; 2,4 ; 2,4
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WOS IDWOS:000323722600036
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/119452
Collection中国科学院大连化学物理研究所
Corresponding AuthorZhuo Du; Li GK(李攻科)
Affiliation1.Sun Yat Sen Univ, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116011, Peoples R China
3.Hong Kong Baptist Univ, Dept Chem, Kowloon Tong, Hong Kong, Peoples R China
Recommended Citation
GB/T 7714
Zhou, Chanyuan,Du, Zhuo,Li, Gongke,et al. Oligomers matrix-assisted dispersion of high content of carbon nanotubes into monolithic column for online separation and enrichment of proteins from complex biological samples[J]. ANALYST,2013,138(19):5783-5790.
APA Zhou, Chanyuan.,Du, Zhuo.,Li, Gongke.,Zhang, Yukui.,Cai, Zongwei.,...&李攻科.(2013).Oligomers matrix-assisted dispersion of high content of carbon nanotubes into monolithic column for online separation and enrichment of proteins from complex biological samples.ANALYST,138(19),5783-5790.
MLA Zhou, Chanyuan,et al."Oligomers matrix-assisted dispersion of high content of carbon nanotubes into monolithic column for online separation and enrichment of proteins from complex biological samples".ANALYST 138.19(2013):5783-5790.
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