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学科主题: 物理化学
题名: Oligomers matrix-assisted dispersion of high content of carbon nanotubes into monolithic column for online separation and enrichment of proteins from complex biological samples
作者: Zhou, Chanyuan1;  Du, Zhuo1;  Li, Gongke1;  Zhang, Yukui2;  Cai, Zongwei3
通讯作者: Zhuo Du ;  李攻科
刊名: ANALYST
发表日期: 2013
DOI: 10.1039/c3an00951c
卷: 138, 期:19, 页:5783-5790
收录类别: SCI
合作性质: 
文章类型: Article
部门归属: 18
项目归属: 1810
产权排名: 待补充
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Analytical
资助者: 2,4
研究领域[WOS]: Chemistry
英文摘要: In this work, a new oligomer matrix-assisted dispersion (OMAD) method for the preparation of homogeneous dispersion of multi-walled carbon nanotubes (MWNTs) incorporated monolithic column was developed. Oligomers matrix as a scaffold could allow MWNTs to entangle with it instead of self-aggregation, so the MWNTs remain in the polymer network followed by in situ self-solidification. The OMAD method not only greatly enlarged the BET surface area of MWNTs incorporated monolithic column from 13.8 m(2) g(-1) to 85.5 m(2) g(-1) without a significant effect on the surface chemistry of the MWNTs, but also improved the dispersion of MWNTs making its content up to 5 wt% (with respect to monomers). The synthesized materials combine the favorable attributes of both high permeability and large surface area, making them excellent candidates for on-line separation and enrichment of proteins. The oligomer matrix-assisted dispersion MWNTs incorporated monolithic columns (OMAD-MMC) exhibited higher enrichment factors and the adsorption capacity is about 5-fold for basic proteins compared with MWNTs incorporated monolithic columns (MMC) prepared by the conventional in situ polymerization. The practical application of OMAD-MMC was proven by selective extraction of hemoglobin in human whole blood samples with SDS-PAGE. On the basis of the results, OMAD as a simple and effective method for dispersion high content MWNTs into monolithic columns shows great promise.
关键词[WOS]: SOLID-PHASE EXTRACTION ;  CAPILLARY ELECTROCHROMATOGRAPHY ;  SMALL MOLECULES ;  BASIC-PROTEINS ;  WATER SAMPLES ;  POLYMER ;  CHROMATOGRAPHY
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000323722600036
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/119452
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Sun Yat Sen Univ, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116011, Peoples R China
3.Hong Kong Baptist Univ, Dept Chem, Kowloon Tong, Hong Kong, Peoples R China

Recommended Citation:
Zhou, Chanyuan,Du, Zhuo,Li, Gongke,et al. Oligomers matrix-assisted dispersion of high content of carbon nanotubes into monolithic column for online separation and enrichment of proteins from complex biological samples[J]. ANALYST,2013,138(19):5783-5790.
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