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学科主题: 物理化学
题名: Selective capture and fluorescent quantification of glycoproteins using aminophenylboronic acid functionalized mesoporous silica coated CdTe quantum dots
作者: Zhang, Wei1, 2;  He, Xi-Wen1, 2;  Yang, Ya-Qiong1, 2;  Li, Wen-You1, 2;  Zhang, Yu-Kui1, 2, 3
通讯作者: 李文友
刊名: JOURNAL OF MATERIALS CHEMISTRY B
发表日期: 2013
DOI: 10.1039/c2tb00022a
卷: 1, 期:3, 页:347-352
收录类别: SCI
合作性质: 
文章类型: Article
部门归属: 18
项目归属: 1810
产权排名: 待补充
WOS标题词: Science & Technology ;  Technology
类目[WOS]: Materials Science, Biomaterials
资助者: 2,5
研究领域[WOS]: Materials Science
英文摘要: In this work, aminophenylboronic acid functionalized mesoporous silica coated CdTe quantum dots (APBA-coated QDs) were synthesized and applied to the selective capture and fluorescent quantification of glycoproteins. The as-prepared APBA-coated QDs, relying on the interaction between APBA and cis-diol containing structures, demonstrated excellent selectivity for the glycoproteins. Their high surface area and APBA-enriched silica matrixes give rise to faster binding kinetics and higher binding capacity for the glycoproteins, which further make them attractive for biomedical/chemical sensing applications. Based on the fluorescent properties of the particles, the as-prepared APBA-coated QDs were successfully applied to the fluorescence quantification of glycoproteins. The present study provides a facile strategy to fabricate functionalized fluorescent materials and is of great significance for isolation and detection of glycoproteins in proteomics.
关键词[WOS]: LECTIN AFFINITY ;  ENRICHMENT ;  CHROMATOGRAPHY ;  GLYCOSYLATION ;  PROTEINS
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000314787400011
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/119459
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Nankai Univ, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
2.Nankai Univ, Dept Chem, Tianjin 300071, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116011, Peoples R China

Recommended Citation:
Zhang, Wei,He, Xi-Wen,Yang, Ya-Qiong,et al. Selective capture and fluorescent quantification of glycoproteins using aminophenylboronic acid functionalized mesoporous silica coated CdTe quantum dots[J]. JOURNAL OF MATERIALS CHEMISTRY B,2013,1(3):347-352.
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