DICP OpenIR
Subject Area物理化学
Synthesis of functionalized 2-pyridones via Michael addition and cyclization reaction of amines, alkynes and dialkyl acetylene dicarboxylates
Chong, Qinglei; Xin, Xiaoyi; Wang, Chunxiang; Wu, Fan; Wan, Boshun; Wan BS(万伯顺)
Source PublicationRSC ADVANCES
2013
DOI10.1039/c3ra43189d
Volume3Issue:44Pages:21222-21226
Indexed BySCI
Cooperation Status
SubtypeArticle
Department2
Funding Project202
Contribution Rank待补充
WOS HeadingsScience & Technology ; Physical Sciences
Funding Organization1,1 ; 1,1 ; 1,1 ; 1,1
WOS SubjectChemistry, Multidisciplinary
WOS Research AreaChemistry
WOS KeywordRING-FUSED 2-PYRIDONES ; REGIOSELECTIVE SYNTHESIS ; PYRIDONE ALKALOIDS ; DERIVATIVES ; MECHANISM ; TRANSFORMATIONS ; CYCLOADDITION ; HYDROLYSIS ; SCAFFOLDS ; MIGRATION
AbstractThe Michael addition and three-component cyclization reaction of amines, alkynes and dialkyl acetylene dicarboxylates to form pyridones has been developed. Aliphatic amines and aromatic amines could selectively be converted into N-alkyl-disubstituted 2-pyridones and N-aryl-trisubstituted 2-pyridones with good yields in the presence of wet ethanol, which means a suitable amount of water is required for this reaction. The Michael addition and cyclization reaction process was confirmed through deuterium-labeling experiments, intermediates isolation and control experiments.
Language英语
Funding Organization1,1 ; 1,1 ; 1,1 ; 1,1
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WOS IDWOS:000326056600005
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/119481
Collection中国科学院大连化学物理研究所
Corresponding AuthorWan BS(万伯顺)
AffiliationChinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Chong, Qinglei,Xin, Xiaoyi,Wang, Chunxiang,et al. Synthesis of functionalized 2-pyridones via Michael addition and cyclization reaction of amines, alkynes and dialkyl acetylene dicarboxylates[J]. RSC ADVANCES,2013,3(44):21222-21226.
APA Chong, Qinglei,Xin, Xiaoyi,Wang, Chunxiang,Wu, Fan,Wan, Boshun,&万伯顺.(2013).Synthesis of functionalized 2-pyridones via Michael addition and cyclization reaction of amines, alkynes and dialkyl acetylene dicarboxylates.RSC ADVANCES,3(44),21222-21226.
MLA Chong, Qinglei,et al."Synthesis of functionalized 2-pyridones via Michael addition and cyclization reaction of amines, alkynes and dialkyl acetylene dicarboxylates".RSC ADVANCES 3.44(2013):21222-21226.
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