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学科主题: 物理化学
题名: Deep understanding of the interaction between thienorphine and UDP-glucuronosyltransferase (UGT) isoforms
作者: Dong, Rui-Hua1;  Fang, Zhong-Ze2, 3;  Zhu, Liang-Liang2;  Ge, Guang-Bo2;  Li, Xiao-Bao4;  Hu, Cui-Min3;  Cao, Yun-Feng2;  Xia, Yang-Liu2;  Yang, Ling2;  Liu, Ze-Yuan1
通讯作者: 杨凌 ;  刘则远
关键词: Thienorphine ;  UDP-glucuronosyltransferase (UGT) ;  drug-drug interaction
刊名: XENOBIOTICA
发表日期: 2013-02-01
DOI: 10.3109/00498254.2012.706723
卷: 43, 期:2, 页:133-139
收录类别: SCI
合作性质: 
文章类型: Article
部门归属: 18
项目归属: 1806
产权排名: 待补充
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Pharmacology & Pharmacy ;  Toxicology
资助者: 2,2
研究领域[WOS]: Pharmacology & Pharmacy ;  Toxicology
英文摘要: 1. Thienorphine has been demonstrated to be a potent, long-acting partial opioid agonist. It is being developed as a good candidate to treat opioid dependence.
关键词[WOS]: LIVER CYTOCHROME-P450 ENZYMES ;  DRUG-DRUG INTERACTIONS ;  GLUCURONIDATION ;  INHIBITION ;  BIOACTIVATION ;  BUPRENORPHINE ;  AGENTS
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000313280700001
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/119568
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Acad Mil Med Sci, Affiliated Hosp, Dept Clin Pharmacol, Beijing 100071, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
3.NCI, Lab Metab, Ctr Canc Res, Bethesda, MD 20892 USA
4.Acad Mil Med Sci, Affiliated Hosp, Dept Breathing Gastroenterol, Beijing 100071, Peoples R China

Recommended Citation:
Dong, Rui-Hua,Fang, Zhong-Ze,Zhu, Liang-Liang,et al. Deep understanding of the interaction between thienorphine and UDP-glucuronosyltransferase (UGT) isoforms[J]. XENOBIOTICA,2013,43(2):133-139.
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