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学科主题: 物理化学
题名: Production and Release of Acylcarnitines by Primary Myotubes Reflect the Differences in Fasting Fat Oxidation of the Donors
作者: Wolf, Magnus1;  Chen, Shili2;  Zhao, Xinjie2;  Scheler, Mika3, 5;  Irmler, Martin3, 5;  Staiger, Harald1, 4, 5;  Beckers, Johannes3, 6;  de Angelis, Martin Hrabe3, 5, 6;  Fritsche, Andreas1, 4, 5;  Haring, Hans-Ulrich1, 4, 5;  Schleicher, Erwin D.1, 4;  Xu, Guowang2;  Lehmann, Rainer1, 4;  Weigert, Cora1, 4
通讯作者: 许国旺 ;  Cora Weigert
刊名: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
发表日期: 2013-06-01
DOI: 10.1210/jc.2012-3976
卷: 98, 期:6, 页:E1137-E1142
收录类别: SCI
合作性质: 
文章类型: Article
部门归属: 18
项目归属: 1808
产权排名: 待补充
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Endocrinology & Metabolism
资助者: 2,1
研究领域[WOS]: Endocrinology & Metabolism
英文摘要: Context: Acylcarnitines are biomarkers of incomplete beta-oxidation and mitochondrial lipid overload but indicate also high rates of mitochondrial fatty acid oxidation. It is unknown whether the production of acylcarnitines in primary human myotubes obtained from lean, metabolically healthy subjects reflects the fat oxidation in vivo.
关键词[WOS]: INTRAMYOCELLULAR LIPID-CONTENT ;  TANDEM MASS-SPECTROMETRY ;  SKELETAL-MUSCLE ;  INSULIN-RESISTANCE ;  CARNITINE METABOLISM ;  MCAD DEFICIENCY ;  BLOOD SPOTS ;  WEIGHT-GAIN ;  OBESITY ;  ACID
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000319736500015
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/119577
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Univ Tubingen, Dept Internal Med, Div Endocrinol Diabetol Angiol Nephrol Pathobioch, D-72076 Tubingen, Germany
2.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
3.German Res Ctr Environm Hlth GmbH, Inst Expt Genet, Helmholtz Zentrum Munchen, D-85764 Neuherberg, Germany
4.Univ Tubingen, Inst Diabet Res & Metab Dis Helmholtz Zentrum, D-72076 Tubingen, Germany
5.Tech Univ Munich, German Ctr Diabet Res DZD, D-85354 Freising Weihenstephan, Germany
6.Tech Univ Munich, Ctr Life & Food Sci Weihenstephan, D-85354 Freising Weihenstephan, Germany

Recommended Citation:
Wolf, Magnus,Chen, Shili,Zhao, Xinjie,et al. Production and Release of Acylcarnitines by Primary Myotubes Reflect the Differences in Fasting Fat Oxidation of the Donors[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM,2013,98(6):E1137-E1142.
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