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学科主题: 物理化学
题名: An intelligent digital microfluidic system with fuzzy-enhanced feedback for multi-droplet manipulation
作者: Gao, Jie1;  Liu, Xianming2;  Chen, Tianlan1;  Mak, Pui-In1;  Du, Yuguang2;  Vai, Mang-I1;  Lin, Bingcheng2;  Martins, Rui P.1
通讯作者: 林炳承 ;  Martins RP
刊名: LAB ON A CHIP
发表日期: 2013
DOI: 10.1039/c2lc41156c
卷: 13, 期:3, 页:443-451
收录类别: SCI
合作性质: 
文章类型: Article
部门归属: 18
项目归属: 1805
产权排名: 待补充
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine ;  Physical Sciences
类目[WOS]: Biochemical Research Methods ;  Chemistry, Multidisciplinary ;  Nanoscience & Nanotechnology
资助者: 2,2
研究领域[WOS]: Biochemistry & Molecular Biology ;  Chemistry ;  Science & Technology - Other Topics
英文摘要: The complexity of droplet hydrodynamics on a digital microfluidic (DMF) system eventually weakens its potential for application in large-scale chemical/biological micro-reactors. We describe here an intelligent DMF technology to address that intricacy. A wide variety of control-engaged droplet manageability is proposed and demonstrated through the operation of our modular DMF prototype, which comprises: (i) rigid profiling ability of different droplet's hydrodynamics under a real-time trajectory track of droplet-derived capacitance, permitting accurate and autonomous multi-droplet positioning without visual setup and heavy image signal processing; (ii) fuzzy-enhanced controllability saving up to 21% charging time when compared with the classical approach, enhancing the throughput, fidelity and lifetime of the DMF chip, while identifying and renouncing those weakened electrodes deteriorated over time, and (iii) expert manipulability of multi-droplet routings under countermeasure decisions in real time, preventing droplet-to-droplet or task-to-task interference. Altogether, this work exhibits the first modular DMF system with built-in electronic-control software-defined intelligence to enhance the fidelity and reliability of each droplet operation, allowing future manufacturability of a wide range of life science analyses and combinatorial chemical screening applications.
关键词[WOS]: ON-A-CHIP ;  ACTUATION ;  BIOCHIPS ;  PLATFORM ;  DEVICES
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000312947300016
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/119592
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Univ Macau, State Key Lab Analog & Mixed Signal VLSI & FST EC, Taipa, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Res Ctr Lab Chip, Dalian, Peoples R China

Recommended Citation:
Gao, Jie,Liu, Xianming,Chen, Tianlan,et al. An intelligent digital microfluidic system with fuzzy-enhanced feedback for multi-droplet manipulation[J]. LAB ON A CHIP,2013,13(3):443-451.
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