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学科主题物理化学
An intelligent digital microfluidic system with fuzzy-enhanced feedback for multi-droplet manipulation
Gao, Jie1; Liu, Xianming2; Chen, Tianlan1; Mak, Pui-In1; Du, Yuguang2; Vai, Mang-I1; Lin, Bingcheng2; Martins, Rui P.1; Lin BC(林炳承); Martins RP
刊名LAB ON A CHIP
2013
ISSN1473-0197
DOI10.1039/c2lc41156c
13期:3页:443-451
收录类别SCI
合作性质
文章类型Article
部门归属18
项目归属1805
产权排名待补充
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
资助者2,2 ; 2,2 ; 2,2 ; 2,2
类目[WOS]Biochemical Research Methods ; Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry ; Science & Technology - Other Topics
关键词[WOS]ON-A-CHIP ; ACTUATION ; BIOCHIPS ; PLATFORM ; DEVICES
英文摘要The complexity of droplet hydrodynamics on a digital microfluidic (DMF) system eventually weakens its potential for application in large-scale chemical/biological micro-reactors. We describe here an intelligent DMF technology to address that intricacy. A wide variety of control-engaged droplet manageability is proposed and demonstrated through the operation of our modular DMF prototype, which comprises: (i) rigid profiling ability of different droplet's hydrodynamics under a real-time trajectory track of droplet-derived capacitance, permitting accurate and autonomous multi-droplet positioning without visual setup and heavy image signal processing; (ii) fuzzy-enhanced controllability saving up to 21% charging time when compared with the classical approach, enhancing the throughput, fidelity and lifetime of the DMF chip, while identifying and renouncing those weakened electrodes deteriorated over time, and (iii) expert manipulability of multi-droplet routings under countermeasure decisions in real time, preventing droplet-to-droplet or task-to-task interference. Altogether, this work exhibits the first modular DMF system with built-in electronic-control software-defined intelligence to enhance the fidelity and reliability of each droplet operation, allowing future manufacturability of a wide range of life science analyses and combinatorial chemical screening applications.
语种英语
资助者2,2 ; 2,2 ; 2,2 ; 2,2
原文出处查看原文
WOS记录号WOS:000312947300016
引用统计
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/119592
专题中国科学院大连化学物理研究所
通讯作者Lin BC(林炳承); Martins RP
作者单位1.Univ Macau, State Key Lab Analog & Mixed Signal VLSI & FST EC, Taipa, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Res Ctr Lab Chip, Dalian, Peoples R China
推荐引用方式
GB/T 7714
Gao, Jie,Liu, Xianming,Chen, Tianlan,et al. An intelligent digital microfluidic system with fuzzy-enhanced feedback for multi-droplet manipulation[J]. LAB ON A CHIP,2013,13(3):443-451.
APA Gao, Jie.,Liu, Xianming.,Chen, Tianlan.,Mak, Pui-In.,Du, Yuguang.,...&Martins RP.(2013).An intelligent digital microfluidic system with fuzzy-enhanced feedback for multi-droplet manipulation.LAB ON A CHIP,13(3),443-451.
MLA Gao, Jie,et al."An intelligent digital microfluidic system with fuzzy-enhanced feedback for multi-droplet manipulation".LAB ON A CHIP 13.3(2013):443-451.
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