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学科主题: 物理化学
题名: The impact of the number of layers of a graphene nanopore on DNA translocation
作者: Lv, Wenping1;  Chen, Maodu2;  Wu, Ren'an1
通讯作者: 吴仁安
刊名: SOFT MATTER
发表日期: 2013
DOI: 10.1039/c2sm26476e
卷: 9, 期:3, 页:960-966
收录类别: SCI
合作性质: 
文章类型: Article
部门归属: 18
项目归属: 18T1
产权排名: 待补充
WOS标题词: Science & Technology ;  Physical Sciences ;  Technology
类目[WOS]: Chemistry, Physical ;  Materials Science, Multidisciplinary ;  Physics, Multidisciplinary ;  Polymer Science
资助者: 1,1
研究领域[WOS]: Chemistry ;  Materials Science ;  Physics ;  Polymer Science
英文摘要: Graphene nanopore based sensor devices have shown great potential for the detection of DNA. To understand the fundamental aspects of DNA translocation through a graphene nanopore, in this work, molecular dynamics (MD) simulations and potential of mean force (PMF) calculations were carried out to investigate the impact of the number of graphene layers of small nanopores (2-3 nm) on DNA translocation. It was observed that the ionic conductance was sensitive to the number of graphene layers of open-nanopores, and the probability of DNA translocation through graphene nanopores was related to the thickness of the graphene nanopores. MD simulations showed that DNA translocation time was most sensitive to the thickness of graphene nanopores of 2.4 nm aperture, and the observed free energy barrier of PMFs and the profile change revealed the increased retardation of DNA translocation through bilayer graphene nanopores as compared to that through monolayer graphene nanopores.
关键词[WOS]: MOLECULAR-DYNAMICS ;  SYNTHETIC NANOPORE ;  NUCLEIC-ACIDS ;  SIMULATION ;  WATER ;  CONDUCTANCE ;  COMPLEXES ;  MEMBRANE ;  POLYMER ;  SENSORS
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000312335500040
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/119600
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog R&A Ctr, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Dalian Univ Technol, Sch Phys & Optoelect Technol, Dalian 116024, Peoples R China

Recommended Citation:
Lv, Wenping,Chen, Maodu,Wu, Ren'an. The impact of the number of layers of a graphene nanopore on DNA translocation[J]. SOFT MATTER,2013,9(3):960-966.
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