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学科主题: 物理化学
题名: Synthesis of NAD analogs to develop bioorthogonal redox system
作者: Ji DeBin1;  Wang Lei1;  Liu WuJun1, 2;  Hou ShuHua1;  ZongBao, Zhao K.1, 2, 3
通讯作者: 赵宗保
关键词: NAD analog ;  bioorthogonal ;  oxidoreductases ;  chemical biology
刊名: SCIENCE CHINA-CHEMISTRY
发表日期: 2013-03-01
DOI: 10.1007/s11426-012-4815-3
卷: 56, 期:3, 页:296-300
收录类别: SCI
合作性质: 
文章类型: Article
部门归属: 18
项目归属: 1816
产权排名: 待补充
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
资助者: 1,1
研究领域[WOS]: Chemistry
英文摘要: Three new nicotinamide adenine dinucleotide (NAD) analogs were synthesized, and their characteristics as cofactors for Escherichia coli malic enzyme (ME) and its double mutant ME L310R/Q401C were analyzed. Each pair of the NAD analog and the double mutant showed good orthogonality to the natural pair of NAD and ME in terms of catalyzing oxidative decarboxylation of l-malic acid. Results indicated that molecular interactions between redox enzyme and cofactor could be further explored to generate new bioorthogonal redox systems.
关键词[WOS]: UNNATURAL NUCLEOTIDE SPECIFICITY ;  DINUCLEOTIDE ;  METHYLTRANSFERASE ;  RECEPTOR
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000314890600005
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/119646
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian Natl Lab Clean Energy, Dalian 116023, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China

Recommended Citation:
Ji DeBin,Wang Lei,Liu WuJun,et al. Synthesis of NAD analogs to develop bioorthogonal redox system[J]. SCIENCE CHINA-CHEMISTRY,2013,56(3):296-300.
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