DICP OpenIR
Subject Area物理化学
Synthesis of NAD analogs to develop bioorthogonal redox system
Ji DeBin1; Wang Lei1; Liu WuJun1,2; Hou ShuHua1; ZongBao, Zhao K.1,2,3; Zhao ZB(赵宗保)
KeywordNad Analog Bioorthogonal Oxidoreductases Chemical Biology
Source PublicationSCIENCE CHINA-CHEMISTRY
2013-03-01
DOI10.1007/s11426-012-4815-3
Volume56Issue:3Pages:296-300
Indexed BySCI
Cooperation Status
SubtypeArticle
Department18
Funding Project1816
Contribution Rank待补充
WOS HeadingsScience & Technology ; Physical Sciences
Funding Organization1,1 ; 1,1 ; 1,1 ; 1,1
WOS SubjectChemistry, Multidisciplinary
WOS Research AreaChemistry
WOS KeywordUNNATURAL NUCLEOTIDE SPECIFICITY ; DINUCLEOTIDE ; METHYLTRANSFERASE ; RECEPTOR
AbstractThree new nicotinamide adenine dinucleotide (NAD) analogs were synthesized, and their characteristics as cofactors for Escherichia coli malic enzyme (ME) and its double mutant ME L310R/Q401C were analyzed. Each pair of the NAD analog and the double mutant showed good orthogonality to the natural pair of NAD and ME in terms of catalyzing oxidative decarboxylation of l-malic acid. Results indicated that molecular interactions between redox enzyme and cofactor could be further explored to generate new bioorthogonal redox systems.
Language英语
Funding Organization1,1 ; 1,1 ; 1,1 ; 1,1
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WOS IDWOS:000314890600005
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/119646
Collection中国科学院大连化学物理研究所
Corresponding AuthorZhao ZB(赵宗保)
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian Natl Lab Clean Energy, Dalian 116023, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Ji DeBin,Wang Lei,Liu WuJun,et al. Synthesis of NAD analogs to develop bioorthogonal redox system[J]. SCIENCE CHINA-CHEMISTRY,2013,56(3):296-300.
APA Ji DeBin,Wang Lei,Liu WuJun,Hou ShuHua,ZongBao, Zhao K.,&赵宗保.(2013).Synthesis of NAD analogs to develop bioorthogonal redox system.SCIENCE CHINA-CHEMISTRY,56(3),296-300.
MLA Ji DeBin,et al."Synthesis of NAD analogs to develop bioorthogonal redox system".SCIENCE CHINA-CHEMISTRY 56.3(2013):296-300.
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