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学科主题物理化学
Metabolomics for tumor marker discovery and identification based on chromatography-mass spectrometry
Yin, Peiyuan; Xu, Guowang; Xu GW(许国旺)
关键词Biomarker Cancer Chromatography Mass Spectrometry Metabolomics Translational Medicine
刊名EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
2013-05-01
ISSN1473-7159
DOI10.1586/ERM.13.23
13期:4页:339-348
收录类别SCI
合作性质
文章类型Review
部门归属18
项目归属1808
产权排名待补充
WOS标题词Science & Technology ; Life Sciences & Biomedicine
资助者1,1 ; 1,1 ; 1,1 ; 1,1
类目[WOS]Pathology
研究领域[WOS]Pathology
关键词[WOS]HUMAN COLORECTAL-CANCER ; DIFFERENTIAL METABOLITE DISCOVERY ; URINARY VOLATILE COMPOUNDS ; AMINO-ACID PROFILES ; CELL LUNG-CANCER ; HEPATOCELLULAR-CARCINOMA ; GAS-CHROMATOGRAPHY ; BREAST-CANCER ; LIVER-CIRRHOSIS ; BLADDER-CANCER
英文摘要Early detection is the most effective way to improve the clinical outcome of malignancies. Although some tumor markers are now widely used in the clinic, their sensitivity and specificity are still not satisfactory. Thus, there is an urgent requirement for the discovery of new tumor markers. By measuring holistic endogenous metabolites, metabolomics can be used for delineating metabolic networks and discovering metabolic markers. Chromatography-mass spectrometry is the most widely used tool for metabolomics and has shown great potential for biomarker screening. In this review, the authors summarize: recent advances in the protocols and methodologies of chromatography-mass spectrometry-based metabolomics in the discovery of tumor markers; recently identified tumor metabolic markers for primary liver cancer, gynecologic cancer and genitourinary cancer and their applications; and commonly encountered problems in the translational research of metabolic markers.
语种英语
资助者1,1 ; 1,1 ; 1,1 ; 1,1
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WOS记录号WOS:000318620900010
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/119657
专题中国科学院大连化学物理研究所
通讯作者Xu GW(许国旺)
作者单位Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
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Yin, Peiyuan,Xu, Guowang,Xu GW. Metabolomics for tumor marker discovery and identification based on chromatography-mass spectrometry[J]. EXPERT REVIEW OF MOLECULAR DIAGNOSTICS,2013,13(4):339-348.
APA Yin, Peiyuan,Xu, Guowang,&许国旺.(2013).Metabolomics for tumor marker discovery and identification based on chromatography-mass spectrometry.EXPERT REVIEW OF MOLECULAR DIAGNOSTICS,13(4),339-348.
MLA Yin, Peiyuan,et al."Metabolomics for tumor marker discovery and identification based on chromatography-mass spectrometry".EXPERT REVIEW OF MOLECULAR DIAGNOSTICS 13.4(2013):339-348.
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