中国科学院大连化学物理研究所机构知识库
Advanced  
DICP OpenIR  > 中国科学院大连化学物理研究所  > 期刊论文
学科主题: 物理化学
题名: Metabolomics for tumor marker discovery and identification based on chromatography-mass spectrometry
作者: Yin, Peiyuan1;  Xu, Guowang1
通讯作者: 许国旺
关键词: biomarker ;  cancer ;  chromatography ;  mass spectrometry ;  metabolomics ;  translational medicine
刊名: EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
发表日期: 2013-05-01
DOI: 10.1586/ERM.13.23
卷: 13, 期:4, 页:339-348
收录类别: SCI
合作性质: 
文章类型: Review
部门归属: 18
项目归属: 1808
产权排名: 待补充
WOS标题词: Science & Technology ;  Life Sciences & Biomedicine
类目[WOS]: Pathology
资助者: 1,1
研究领域[WOS]: Pathology
英文摘要: Early detection is the most effective way to improve the clinical outcome of malignancies. Although some tumor markers are now widely used in the clinic, their sensitivity and specificity are still not satisfactory. Thus, there is an urgent requirement for the discovery of new tumor markers. By measuring holistic endogenous metabolites, metabolomics can be used for delineating metabolic networks and discovering metabolic markers. Chromatography-mass spectrometry is the most widely used tool for metabolomics and has shown great potential for biomarker screening. In this review, the authors summarize: recent advances in the protocols and methodologies of chromatography-mass spectrometry-based metabolomics in the discovery of tumor markers; recently identified tumor metabolic markers for primary liver cancer, gynecologic cancer and genitourinary cancer and their applications; and commonly encountered problems in the translational research of metabolic markers.
关键词[WOS]: HUMAN COLORECTAL-CANCER ;  DIFFERENTIAL METABOLITE DISCOVERY ;  URINARY VOLATILE COMPOUNDS ;  AMINO-ACID PROFILES ;  CELL LUNG-CANCER ;  HEPATOCELLULAR-CARCINOMA ;  GAS-CHROMATOGRAPHY ;  BREAST-CANCER ;  LIVER-CIRRHOSIS ;  BLADDER-CANCER
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000318620900010
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/119657
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
2013Ykpa7Bi9P2.PDF(1297KB)----开放获取View Download

作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China

Recommended Citation:
Yin, Peiyuan,Xu, Guowang. Metabolomics for tumor marker discovery and identification based on chromatography-mass spectrometry[J]. EXPERT REVIEW OF MOLECULAR DIAGNOSTICS,2013,13(4):339-348.
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Yin, Peiyuan]'s Articles
 [Xu, Guowang]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Yin, Peiyuan]‘s Articles
 [Xu, Guowang]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
文件名: 2013Ykpa7Bi9P2.PDF
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace