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学科主题: 物理化学
题名: Effect of plasma components on the stability and permeability of microcapsule
作者: Chen, Li1, 2;  Zhang, Ying1;  Li, Shen1, 2;  Wang, Xiuli1;  Li, Na1, 2;  Wang, Yu1, 2;  Guo, Xin1;  Zhao, Shan1;  Yu, Weiting1;  Sun, Guangwei1;  Liu, Yang1;  Ma, Xiaojun1
通讯作者: 马小军 ;  张英
关键词: microcapsules ;  bioartificial liver ;  plasma ;  mechanical stability ;  permeability
刊名: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
发表日期: 2014-07-01
DOI: 10.1002/jbm.a.34907
卷: 102, 期:7, 页:2408-2416
收录类别: SCI
合作性质: 
文章类型: Article
部门归属: 18
项目归属: 1802
产权排名: 待补充
WOS标题词: Science & Technology ;  Technology
类目[WOS]: Engineering, Biomedical ;  Materials Science, Biomaterials
资助者: 1,1
研究领域[WOS]: Engineering ;  Materials Science
英文摘要: Immobilization of hepatocytes in microcapsules has been a potentially alternative methodology for bioartificial livers (BALs). Moreover, the stability and permeability are the key parameters of these microcapsules. However, these alginate-based microcapsules are unstable if the surrounding medium disrupts the ionic interactions between alginate and the polycation. As hundreds of components are included in human plasma, the stability and permeability in plasma of microcapsules need to be sufficiently investigated. In the present study, the stability of three kinds of alginate-based microcapsules was evaluated when they were immersed in plasma. Our results showed that stability of alginate--poly (l-lysine)-alginate (-APA) microcapsules was well maintained, better than those of alginate-epsilon-poly (l-lysine)-alginate (epsilon-APA) and alginate-chitosan-alginate (ACA) microcapsules. Also, factors affecting the stability of microcapsules in plasma were analyzed and it showed that heparin was the key factor that affected the stability of -APA microcapsules, whereas heparin and low molecular electrolytes such as HCO3- and H2PO4-/HPO42- were the factors to epsilon-APA and ACA microcapsules. In addition, the permeability evaluation showed no decrease in permeability of microcapsules after incubation in plasma. Our study might provide a foundation for the selection and modification of materials for microcapsule-based BAL devices. (c) 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 2408-2416, 2014.
关键词[WOS]: FLUIDIZED-BED BIOREACTOR ;  LIVER SUPPORT-SYSTEMS ;  BIOARTIFICIAL LIVER ;  ALGINATE MICROCAPSULES ;  MECHANICAL-PROPERTIES ;  IN-VITRO ;  HEPATOCYTES ;  CHITOSAN ;  OPTIMIZATION ;  MEMBRANE
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000337570400037
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/119706
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China

Recommended Citation:
Chen, Li,Zhang, Ying,Li, Shen,et al. Effect of plasma components on the stability and permeability of microcapsule[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2014,102(7):2408-2416.
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