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学科主题物理化学
Effect of plasma components on the stability and permeability of microcapsule
Chen, Li1,2; Zhang, Ying1; Li, Shen1,2; Wang, Xiuli1; Li, Na1,2; Wang, Yu1,2; Guo, Xin1; Zhao, Shan1; Yu, Weiting1; Sun, Guangwei1; Liu, Yang1; Ma, Xiaojun1; Ma XJ(马小军); Zhang Y(张英)
关键词Microcapsules Bioartificial Liver Plasma Mechanical Stability Permeability
刊名JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
2014-07-01
DOI10.1002/jbm.a.34907
102期:7页:2408-2416
收录类别SCI
合作性质
文章类型Article
部门归属18
项目归属1802
产权排名待补充
WOS标题词Science & Technology ; Technology
资助者1,1 ; 1,1 ; 1,1 ; 1,1
类目[WOS]Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]Engineering ; Materials Science
关键词[WOS]FLUIDIZED-BED BIOREACTOR ; LIVER SUPPORT-SYSTEMS ; BIOARTIFICIAL LIVER ; ALGINATE MICROCAPSULES ; MECHANICAL-PROPERTIES ; IN-VITRO ; HEPATOCYTES ; CHITOSAN ; OPTIMIZATION ; MEMBRANE
英文摘要Immobilization of hepatocytes in microcapsules has been a potentially alternative methodology for bioartificial livers (BALs). Moreover, the stability and permeability are the key parameters of these microcapsules. However, these alginate-based microcapsules are unstable if the surrounding medium disrupts the ionic interactions between alginate and the polycation. As hundreds of components are included in human plasma, the stability and permeability in plasma of microcapsules need to be sufficiently investigated. In the present study, the stability of three kinds of alginate-based microcapsules was evaluated when they were immersed in plasma. Our results showed that stability of alginate--poly (l-lysine)-alginate (-APA) microcapsules was well maintained, better than those of alginate-epsilon-poly (l-lysine)-alginate (epsilon-APA) and alginate-chitosan-alginate (ACA) microcapsules. Also, factors affecting the stability of microcapsules in plasma were analyzed and it showed that heparin was the key factor that affected the stability of -APA microcapsules, whereas heparin and low molecular electrolytes such as HCO3- and H2PO4-/HPO42- were the factors to epsilon-APA and ACA microcapsules. In addition, the permeability evaluation showed no decrease in permeability of microcapsules after incubation in plasma. Our study might provide a foundation for the selection and modification of materials for microcapsule-based BAL devices. (c) 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 2408-2416, 2014.
语种英语
资助者1,1 ; 1,1 ; 1,1 ; 1,1
原文出处查看原文
WOS记录号WOS:000337570400037
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/119706
专题中国科学院大连化学物理研究所
通讯作者Ma XJ(马小军); Zhang Y(张英)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714
Chen, Li,Zhang, Ying,Li, Shen,et al. Effect of plasma components on the stability and permeability of microcapsule[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2014,102(7):2408-2416.
APA Chen, Li.,Zhang, Ying.,Li, Shen.,Wang, Xiuli.,Li, Na.,...&张英.(2014).Effect of plasma components on the stability and permeability of microcapsule.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,102(7),2408-2416.
MLA Chen, Li,et al."Effect of plasma components on the stability and permeability of microcapsule".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 102.7(2014):2408-2416.
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