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学科主题物理化学
Development and Application of Hydrophilic Interaction Liquid Chromatographic Stationary Phases
Shen Aijin; Guo Zhimou; Liang Xinmiao; Liang XM(梁鑫淼)
关键词Hydrophilic Interaction Liquid Chromatography Stationary Phase Polar Drugs Proteomics Metabolomics
刊名PROGRESS IN CHEMISTRY
2014
ISSN1005-281X
DOI10.7536/PC130661
26期:1页:10-18
收录类别SCI
合作性质
文章类型Review
部门归属18
项目归属1803
产权排名待补充
WOS标题词Science & Technology ; Physical Sciences
资助者1,1 ; 1,1 ; 1,1 ; 1,1
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]MONOLITHIC CAPILLARY COLUMN ; TANDEM MASS-SPECTROMETRY ; LIGHT-SCATTERING DETECTION ; MIXED-MODE ; POLAR COMPOUNDS ; CATION-EXCHANGE ; PEPTIDE SEPARATION ; CHARGED SOLUTES ; REVERSED-PHASE ; SILICA COLUMNS
英文摘要As an alternative high performance liquid chromatography technology, hydrophilic interaction liquid chromatography (HILIC) plays an important role in the separation of highly polar and ionic compounds such as amino acids, carbohydrates, peptides and so on. The development of HILIC stationary phases, which are considered as the core of chromatographic technology, is of great importance for the improvement of chromatographic separation selectivity and efficiency, influencing the application and generalization of HILIC. To date, a great variety of commercial and academic HILIC materials with abundant functional groups have been presented. According to the functional groups of chromatographic materials, the development of silica-based HILIC stationary phases including unmodified silica, amino-based, cyano-based, diol-based, amide-based, poly (succinimide) -based, saccharides-based and zwitterion-based stationary phases are reviewed in the present article. Meanwhile, the typical applications of HILIC stationary phases in polar drugs separation, bioanalysis, proteomics, metabolomics, etc. are included. With increasing diversity of HILIC materials, the selection of appropriate HILIC stationary phase for the resolution of complex compounds becomes difficult. The development of systematic test samples and methods to access the separation selectivity is of great value for understanding the interaction mechanism of HILIC stationary phases. Thus, the investigation involving test samples to evaluate separation efficiencies and selectivities in HILIC is also reviewed.
语种英语
资助者1,1 ; 1,1 ; 1,1 ; 1,1
原文出处查看原文
WOS记录号WOS:000330554500002
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/119720
专题中国科学院大连化学物理研究所
通讯作者Liang XM(梁鑫淼)
作者单位Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
推荐引用方式
GB/T 7714
Shen Aijin,Guo Zhimou,Liang Xinmiao,et al. Development and Application of Hydrophilic Interaction Liquid Chromatographic Stationary Phases[J]. PROGRESS IN CHEMISTRY,2014,26(1):10-18.
APA Shen Aijin,Guo Zhimou,Liang Xinmiao,&梁鑫淼.(2014).Development and Application of Hydrophilic Interaction Liquid Chromatographic Stationary Phases.PROGRESS IN CHEMISTRY,26(1),10-18.
MLA Shen Aijin,et al."Development and Application of Hydrophilic Interaction Liquid Chromatographic Stationary Phases".PROGRESS IN CHEMISTRY 26.1(2014):10-18.
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