DICP OpenIR
Subject Area物理化学
Development and Application of Hydrophilic Interaction Liquid Chromatographic Stationary Phases
Shen Aijin; Guo Zhimou; Liang Xinmiao; Liang XM(梁鑫淼)
KeywordHydrophilic Interaction Liquid Chromatography Stationary Phase Polar Drugs Proteomics Metabolomics
Source PublicationPROGRESS IN CHEMISTRY
2014
ISSN1005-281X
DOI10.7536/PC130661
Volume26Issue:1Pages:10-18
Indexed BySCI
Cooperation Status
SubtypeReview
Department18
Funding Project1803
Contribution Rank待补充
WOS HeadingsScience & Technology ; Physical Sciences
Funding Organization1,1 ; 1,1 ; 1,1 ; 1,1
WOS SubjectChemistry, Multidisciplinary
WOS Research AreaChemistry
WOS KeywordMONOLITHIC CAPILLARY COLUMN ; TANDEM MASS-SPECTROMETRY ; LIGHT-SCATTERING DETECTION ; MIXED-MODE ; POLAR COMPOUNDS ; CATION-EXCHANGE ; PEPTIDE SEPARATION ; CHARGED SOLUTES ; REVERSED-PHASE ; SILICA COLUMNS
AbstractAs an alternative high performance liquid chromatography technology, hydrophilic interaction liquid chromatography (HILIC) plays an important role in the separation of highly polar and ionic compounds such as amino acids, carbohydrates, peptides and so on. The development of HILIC stationary phases, which are considered as the core of chromatographic technology, is of great importance for the improvement of chromatographic separation selectivity and efficiency, influencing the application and generalization of HILIC. To date, a great variety of commercial and academic HILIC materials with abundant functional groups have been presented. According to the functional groups of chromatographic materials, the development of silica-based HILIC stationary phases including unmodified silica, amino-based, cyano-based, diol-based, amide-based, poly (succinimide) -based, saccharides-based and zwitterion-based stationary phases are reviewed in the present article. Meanwhile, the typical applications of HILIC stationary phases in polar drugs separation, bioanalysis, proteomics, metabolomics, etc. are included. With increasing diversity of HILIC materials, the selection of appropriate HILIC stationary phase for the resolution of complex compounds becomes difficult. The development of systematic test samples and methods to access the separation selectivity is of great value for understanding the interaction mechanism of HILIC stationary phases. Thus, the investigation involving test samples to evaluate separation efficiencies and selectivities in HILIC is also reviewed.
Language英语
Funding Organization1,1 ; 1,1 ; 1,1 ; 1,1
URL查看原文
WOS IDWOS:000330554500002
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/119720
Collection中国科学院大连化学物理研究所
Corresponding AuthorLiang XM(梁鑫淼)
AffiliationChinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
Recommended Citation
GB/T 7714
Shen Aijin,Guo Zhimou,Liang Xinmiao,et al. Development and Application of Hydrophilic Interaction Liquid Chromatographic Stationary Phases[J]. PROGRESS IN CHEMISTRY,2014,26(1):10-18.
APA Shen Aijin,Guo Zhimou,Liang Xinmiao,&梁鑫淼.(2014).Development and Application of Hydrophilic Interaction Liquid Chromatographic Stationary Phases.PROGRESS IN CHEMISTRY,26(1),10-18.
MLA Shen Aijin,et al."Development and Application of Hydrophilic Interaction Liquid Chromatographic Stationary Phases".PROGRESS IN CHEMISTRY 26.1(2014):10-18.
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