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学科主题: 物理化学
题名: Development and Application of Hydrophilic Interaction Liquid Chromatographic Stationary Phases
作者: Shen Aijin1;  Guo Zhimou1;  Liang Xinmiao1
通讯作者: 梁鑫淼
关键词: hydrophilic interaction liquid chromatography ;  stationary phase ;  polar drugs ;  proteomics ;  metabolomics
刊名: PROGRESS IN CHEMISTRY
发表日期: 2014
DOI: 10.7536/PC130661
卷: 26, 期:1, 页:10-18
收录类别: SCI
合作性质: 
文章类型: Review
部门归属: 18
项目归属: 1803
产权排名: 待补充
WOS标题词: Science & Technology ;  Physical Sciences
类目[WOS]: Chemistry, Multidisciplinary
资助者: 1,1
研究领域[WOS]: Chemistry
英文摘要: As an alternative high performance liquid chromatography technology, hydrophilic interaction liquid chromatography (HILIC) plays an important role in the separation of highly polar and ionic compounds such as amino acids, carbohydrates, peptides and so on. The development of HILIC stationary phases, which are considered as the core of chromatographic technology, is of great importance for the improvement of chromatographic separation selectivity and efficiency, influencing the application and generalization of HILIC. To date, a great variety of commercial and academic HILIC materials with abundant functional groups have been presented. According to the functional groups of chromatographic materials, the development of silica-based HILIC stationary phases including unmodified silica, amino-based, cyano-based, diol-based, amide-based, poly (succinimide) -based, saccharides-based and zwitterion-based stationary phases are reviewed in the present article. Meanwhile, the typical applications of HILIC stationary phases in polar drugs separation, bioanalysis, proteomics, metabolomics, etc. are included. With increasing diversity of HILIC materials, the selection of appropriate HILIC stationary phase for the resolution of complex compounds becomes difficult. The development of systematic test samples and methods to access the separation selectivity is of great value for understanding the interaction mechanism of HILIC stationary phases. Thus, the investigation involving test samples to evaluate separation efficiencies and selectivities in HILIC is also reviewed.
关键词[WOS]: MONOLITHIC CAPILLARY COLUMN ;  TANDEM MASS-SPECTROMETRY ;  LIGHT-SCATTERING DETECTION ;  MIXED-MODE ;  POLAR COMPOUNDS ;  CATION-EXCHANGE ;  PEPTIDE SEPARATION ;  CHARGED SOLUTES ;  REVERSED-PHASE ;  SILICA COLUMNS
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000330554500002
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/119720
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China

Recommended Citation:
Shen Aijin,Guo Zhimou,Liang Xinmiao. Development and Application of Hydrophilic Interaction Liquid Chromatographic Stationary Phases[J]. PROGRESS IN CHEMISTRY,2014,26(1):10-18.
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