DICP OpenIR
学科主题物理化学
Metabolomics research on time-selected combination of Liuwei Dihuang and Jinkui Shenqi pills in treating kidney deficiency and aging by chemometric methods
Zhang, Liangxiao1,2; Han, Xiaofei1,3; Li, Zhan4; Liu, Renhui4; Xu, Wenjuan1; Tang, Chunlan1; Wang, Xiujuan4; Xiao, Hongbin1; Zhang LX(张良晓); Xiujuan Wang; Xiao HB(肖红斌)
关键词Metabolomics Kidney Deficiency And Aging Time-selected Combination Metabolic Pathway
刊名CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS
2014-01-15
DOI10.1016/j.chemolab.2013.09.001
130页:50-57
收录类别SCI
合作性质
文章类型Article
部门归属18
项目归属1804
产权排名待补充
WOS标题词Science & Technology ; Technology ; Physical Sciences
资助者1,1 ; 1,1 ; 1,1 ; 1,1
类目[WOS]Automation & Control Systems ; Chemistry, Analytical ; Computer Science, Artificial Intelligence ; Instruments & Instrumentation ; Mathematics, Interdisciplinary Applications ; Statistics & Probability
研究领域[WOS]Automation & Control Systems ; Chemistry ; Computer Science ; Instruments & Instrumentation ; Mathematics
关键词[WOS]MS/MS-BASED METABOLOMICS ; VARIABLE SELECTION ; MASS-SPECTROMETRY ; MULTIVARIATE CALIBRATION ; UNINFORMATIVE VARIABLES ; BIOMARKER DISCOVERY ; GRAPHICAL INDEX ; ELIMINATION ; IDENTIFICATION ; METABONOMICS
英文摘要Jinkui Shenqi pill (JKSQ) and Liuwei Dihuang (LWDH) pills are ancient traditional Chinese medicines (TCMs), which are usually used for the treatment of kidney deficiency for thousands of years in China. Time-selected combination of LWDH and JKSQ pills in treating kidney deficiency and aging is one of the features of traditional Chinese medicines (TCMs). However, the molecular mechanisms of time-selected combination remain unclear. In this work, UHPLC-QTOF/MS based metabolomics research was conducted to evaluate the therapeutic effect of LWDH, JKSQ pills and their combinations on kidney deficiency in Sprague-Dawley rats induced by D-galactose and Dexamethasone. Based on peak areas of serum extracts, analysis of variance (ANOVA) and graphical index of separation (GIOS) were employed to select the significant variables for kidney deficiency and aging and principal component projection (PCP) was subsequently applied to evaluate the influence of drugs on endogenous metabolites. 10 endogenous metabolites from 22 important ions were identified via database search. The score plot of PCA shows that nourishing Yang-nourishing Yin group shows the strongest rehabilitation for metabolic disorder induced by kidney deficiency and aging, which is consistent with the classic theories of traditional Chinese medicine. Moreover, metabolic pathway function analysis indicates that kidney deficiency and aging might possess closed relationships with lipid metabolism and energy metabolism. In this work, the change trends of potential biomarkers after administration provide molecular evidence for combined administration of Jinkui Shenqi pill in the morning and Liuwei Dihuang pill at night for the patients with kidney deficiency. The method proposed in this study may provide inspiration for evaluation of the therapeutic effect of Chinese medicines by comparing the rehabilitation of potential biomarkers. (C) 2013 Elsevier B.V. All rights reserved.
语种英语
资助者1,1 ; 1,1 ; 1,1 ; 1,1
原文出处查看原文
WOS记录号WOS:000330914900008
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/119770
专题中国科学院大连化学物理研究所
通讯作者Zhang LX(张良晓); Xiujuan Wang; Xiao HB(肖红斌)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Chinese Acad Agr Sci, Oil Crops Res Inst, Wuhan 430062, Peoples R China
3.Dalian Univ, Coll Environm & Chem Engn, Dalian 116622, Peoples R China
4.Capital Med Univ, Sch Tradit Chinese Med, Beijing 100069, Peoples R China
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Zhang, Liangxiao,Han, Xiaofei,Li, Zhan,et al. Metabolomics research on time-selected combination of Liuwei Dihuang and Jinkui Shenqi pills in treating kidney deficiency and aging by chemometric methods[J]. CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS,2014,130:50-57.
APA Zhang, Liangxiao.,Han, Xiaofei.,Li, Zhan.,Liu, Renhui.,Xu, Wenjuan.,...&肖红斌.(2014).Metabolomics research on time-selected combination of Liuwei Dihuang and Jinkui Shenqi pills in treating kidney deficiency and aging by chemometric methods.CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS,130,50-57.
MLA Zhang, Liangxiao,et al."Metabolomics research on time-selected combination of Liuwei Dihuang and Jinkui Shenqi pills in treating kidney deficiency and aging by chemometric methods".CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS 130(2014):50-57.
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