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学科主题: 物理化学
题名: Metabolomics research on time-selected combination of Liuwei Dihuang and Jinkui Shenqi pills in treating kidney deficiency and aging by chemometric methods
作者: Zhang, Liangxiao1, 2;  Han, Xiaofei1, 3;  Li, Zhan4;  Liu, Renhui4;  Xu, Wenjuan1;  Tang, Chunlan1;  Wang, Xiujuan4;  Xiao, Hongbin1
通讯作者: 张良晓 ;  Xiujuan Wang ;  肖红斌
关键词: Metabolomics ;  Kidney deficiency and aging ;  Time-selected combination ;  Metabolic pathway
刊名: CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS
发表日期: 2014-01-15
DOI: 10.1016/j.chemolab.2013.09.001
卷: 130, 页:50-57
收录类别: SCI
合作性质: 
文章类型: Article
部门归属: 18
项目归属: 1804
产权排名: 待补充
WOS标题词: Science & Technology ;  Technology ;  Physical Sciences
类目[WOS]: Automation & Control Systems ;  Chemistry, Analytical ;  Computer Science, Artificial Intelligence ;  Instruments & Instrumentation ;  Mathematics, Interdisciplinary Applications ;  Statistics & Probability
资助者: 1,1
研究领域[WOS]: Automation & Control Systems ;  Chemistry ;  Computer Science ;  Instruments & Instrumentation ;  Mathematics
英文摘要: Jinkui Shenqi pill (JKSQ) and Liuwei Dihuang (LWDH) pills are ancient traditional Chinese medicines (TCMs), which are usually used for the treatment of kidney deficiency for thousands of years in China. Time-selected combination of LWDH and JKSQ pills in treating kidney deficiency and aging is one of the features of traditional Chinese medicines (TCMs). However, the molecular mechanisms of time-selected combination remain unclear. In this work, UHPLC-QTOF/MS based metabolomics research was conducted to evaluate the therapeutic effect of LWDH, JKSQ pills and their combinations on kidney deficiency in Sprague-Dawley rats induced by D-galactose and Dexamethasone. Based on peak areas of serum extracts, analysis of variance (ANOVA) and graphical index of separation (GIOS) were employed to select the significant variables for kidney deficiency and aging and principal component projection (PCP) was subsequently applied to evaluate the influence of drugs on endogenous metabolites. 10 endogenous metabolites from 22 important ions were identified via database search. The score plot of PCA shows that nourishing Yang-nourishing Yin group shows the strongest rehabilitation for metabolic disorder induced by kidney deficiency and aging, which is consistent with the classic theories of traditional Chinese medicine. Moreover, metabolic pathway function analysis indicates that kidney deficiency and aging might possess closed relationships with lipid metabolism and energy metabolism. In this work, the change trends of potential biomarkers after administration provide molecular evidence for combined administration of Jinkui Shenqi pill in the morning and Liuwei Dihuang pill at night for the patients with kidney deficiency. The method proposed in this study may provide inspiration for evaluation of the therapeutic effect of Chinese medicines by comparing the rehabilitation of potential biomarkers. (C) 2013 Elsevier B.V. All rights reserved.
关键词[WOS]: MS/MS-BASED METABOLOMICS ;  VARIABLE SELECTION ;  MASS-SPECTROMETRY ;  MULTIVARIATE CALIBRATION ;  UNINFORMATIVE VARIABLES ;  BIOMARKER DISCOVERY ;  GRAPHICAL INDEX ;  ELIMINATION ;  IDENTIFICATION ;  METABONOMICS
语种: 英语
原文出处: 查看原文
WOS记录号: WOS:000330914900008
Citation statistics: 
内容类型: 期刊论文
URI标识: http://cas-ir.dicp.ac.cn/handle/321008/119770
Appears in Collections:中国科学院大连化学物理研究所_期刊论文

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作者单位: 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
2.Chinese Acad Agr Sci, Oil Crops Res Inst, Wuhan 430062, Peoples R China
3.Dalian Univ, Coll Environm & Chem Engn, Dalian 116622, Peoples R China
4.Capital Med Univ, Sch Tradit Chinese Med, Beijing 100069, Peoples R China

Recommended Citation:
Zhang, Liangxiao,Han, Xiaofei,Li, Zhan,et al. Metabolomics research on time-selected combination of Liuwei Dihuang and Jinkui Shenqi pills in treating kidney deficiency and aging by chemometric methods[J]. CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS,2014,130:50-57.
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