DICP OpenIR
学科主题物理化学
Facile fabrication of a near-infrared responsive nanocarrier for spatiotemporally controlled chemo-photothermal synergistic cancer therapy
Wan, Hao1,2; Zhang, Yi1; Liu, Zheyi1; Xu, Guiju1; Huang, Guang1; Ji, Yongsheng1; Xiong, Zhichao1,2; Zhang, Quanqing1; Dong, Jing1; Zhang, Weibing2; Zou, Hanfa1; Zou HF(邹汉法); Zhang WB(张维冰)
刊名NANOSCALE
2014-08-07
ISSN2040-3364
DOI10.1039/c4nr01044b
6期:15页:8743-8753
收录类别SCI
合作性质
文章类型Article
部门归属18
项目归属1809
产权排名待补充
WOS标题词Science & Technology ; Physical Sciences ; Technology
资助者1,1 ; 1,1 ; 1,1 ; 1,1
类目[WOS]Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
研究领域[WOS]Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]MESOPOROUS SILICA NANOPARTICLES ; CONTROLLED DRUG-RELEASE ; FUNCTIONALIZED GRAPHENE OXIDE ; I-MOTIF DNA ; ANTICANCER DRUG ; EFFICIENT ; DELIVERY ; LIGHT ; CELLS ; VIVO
英文摘要Remote-controlled nanocarriers for drug delivery are of great promise to provide timely, sensitive and spatiotemporally selective treatments for cancer therapy. Due to convenient and precise manipulation, deep penetration through tissues and excellent biocompatibility, near-infrared (NIR) irradiation is a preferred external stimulus for triggering the release of loaded drugs. In this work, for spatiotemporally controlled chemo-photothermal synergistic cancer therapy, a NIR responsive nanocarrier was fabricated using reduced graphene oxide nanosheets (rNGO) decorated with mesoporous silica shell and the subsequent functionalization of the thermoresponsive polymer brushes (pNIPAM-co-pAAm) at the outlet of the silica pore channels. rNGO, which combined with the mesoporous silica shell provide a high loading capacity for anticancer drugs (doxorubicin, DOX), was assigned to sense NIR irradiation for the manipulation of pNIPAM-co-pAAm valve to control the diffusion of loaded DOX. Under NIR irradiation, rNGO would generate heat, which could not only elevate the surrounding temperature over the low critical solution temperature (LCST) of pNIPAM-co-pAAm to open the thermoresponsive polymer valve and promote the diffusion of DOX, but also kill the cancer cells through the hypothermia effect. By manipulating NIR irradiation, the nanocarrier exhibited efficiently controlled release of loaded DOX both in the buffer and in living HeLa cells (the model cancer cells), providing powerful and site-targeted treatments, which can be attributed to synergistic effects of chemo-photothermal therapy. To sum up, this novel nanocarrier is an excellent drug delivery platform in remote-controlled chemo-photothermal synergistic cancer therapy via NIR irradiation.
语种英语
资助者1,1 ; 1,1 ; 1,1 ; 1,1
原文出处查看原文
WOS记录号WOS:000339861500044
引用统计
被引频次:36[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://cas-ir.dicp.ac.cn/handle/321008/119778
专题中国科学院大连化学物理研究所
通讯作者Zou HF(邹汉法); Zhang WB(张维冰)
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China
2.E China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China
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GB/T 7714
Wan, Hao,Zhang, Yi,Liu, Zheyi,et al. Facile fabrication of a near-infrared responsive nanocarrier for spatiotemporally controlled chemo-photothermal synergistic cancer therapy[J]. NANOSCALE,2014,6(15):8743-8753.
APA Wan, Hao.,Zhang, Yi.,Liu, Zheyi.,Xu, Guiju.,Huang, Guang.,...&张维冰.(2014).Facile fabrication of a near-infrared responsive nanocarrier for spatiotemporally controlled chemo-photothermal synergistic cancer therapy.NANOSCALE,6(15),8743-8753.
MLA Wan, Hao,et al."Facile fabrication of a near-infrared responsive nanocarrier for spatiotemporally controlled chemo-photothermal synergistic cancer therapy".NANOSCALE 6.15(2014):8743-8753.
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