DICP OpenIR
Subject Area物理化学
Facile fabrication of a near-infrared responsive nanocarrier for spatiotemporally controlled chemo-photothermal synergistic cancer therapy
Wan, Hao1,2; Zhang, Yi1; Liu, Zheyi1; Xu, Guiju1; Huang, Guang1; Ji, Yongsheng1; Xiong, Zhichao1,2; Zhang, Quanqing1; Dong, Jing1; Zhang, Weibing2; Zou, Hanfa1; Zou HF(邹汉法); Zhang WB(张维冰)
Source PublicationNANOSCALE
2014-08-07
ISSN2040-3364
DOI10.1039/c4nr01044b
Volume6Issue:15Pages:8743-8753
Indexed BySCI
Cooperation Status
SubtypeArticle
Department18
Funding Project1809
Contribution Rank待补充
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
Funding Organization1,1 ; 1,1 ; 1,1 ; 1,1
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS KeywordMESOPOROUS SILICA NANOPARTICLES ; CONTROLLED DRUG-RELEASE ; FUNCTIONALIZED GRAPHENE OXIDE ; I-MOTIF DNA ; ANTICANCER DRUG ; EFFICIENT ; DELIVERY ; LIGHT ; CELLS ; VIVO
AbstractRemote-controlled nanocarriers for drug delivery are of great promise to provide timely, sensitive and spatiotemporally selective treatments for cancer therapy. Due to convenient and precise manipulation, deep penetration through tissues and excellent biocompatibility, near-infrared (NIR) irradiation is a preferred external stimulus for triggering the release of loaded drugs. In this work, for spatiotemporally controlled chemo-photothermal synergistic cancer therapy, a NIR responsive nanocarrier was fabricated using reduced graphene oxide nanosheets (rNGO) decorated with mesoporous silica shell and the subsequent functionalization of the thermoresponsive polymer brushes (pNIPAM-co-pAAm) at the outlet of the silica pore channels. rNGO, which combined with the mesoporous silica shell provide a high loading capacity for anticancer drugs (doxorubicin, DOX), was assigned to sense NIR irradiation for the manipulation of pNIPAM-co-pAAm valve to control the diffusion of loaded DOX. Under NIR irradiation, rNGO would generate heat, which could not only elevate the surrounding temperature over the low critical solution temperature (LCST) of pNIPAM-co-pAAm to open the thermoresponsive polymer valve and promote the diffusion of DOX, but also kill the cancer cells through the hypothermia effect. By manipulating NIR irradiation, the nanocarrier exhibited efficiently controlled release of loaded DOX both in the buffer and in living HeLa cells (the model cancer cells), providing powerful and site-targeted treatments, which can be attributed to synergistic effects of chemo-photothermal therapy. To sum up, this novel nanocarrier is an excellent drug delivery platform in remote-controlled chemo-photothermal synergistic cancer therapy via NIR irradiation.
Language英语
Funding Organization1,1 ; 1,1 ; 1,1 ; 1,1
URL查看原文
WOS IDWOS:000339861500044
Citation statistics
Cited Times:38[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://cas-ir.dicp.ac.cn/handle/321008/119778
Collection中国科学院大连化学物理研究所
Corresponding AuthorZou HF(邹汉法); Zhang WB(张维冰)
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China
2.E China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China
Recommended Citation
GB/T 7714
Wan, Hao,Zhang, Yi,Liu, Zheyi,et al. Facile fabrication of a near-infrared responsive nanocarrier for spatiotemporally controlled chemo-photothermal synergistic cancer therapy[J]. NANOSCALE,2014,6(15):8743-8753.
APA Wan, Hao.,Zhang, Yi.,Liu, Zheyi.,Xu, Guiju.,Huang, Guang.,...&张维冰.(2014).Facile fabrication of a near-infrared responsive nanocarrier for spatiotemporally controlled chemo-photothermal synergistic cancer therapy.NANOSCALE,6(15),8743-8753.
MLA Wan, Hao,et al."Facile fabrication of a near-infrared responsive nanocarrier for spatiotemporally controlled chemo-photothermal synergistic cancer therapy".NANOSCALE 6.15(2014):8743-8753.
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